S-531011, a Novel Anti-Human CCR8 Antibody, Induces Potent Antitumor Responses through Depletion of Tumor-Infiltrating CCR8-Expressing Regulatory T Cells

por Nagira, Yoji, Nagira, Morio, Nagai, Ryohei, Nogami, Wataru, Hirata, Michinari, Ueyama, Azumi, Yoshida, Tetsuya, Yoshikawa, Mai, Shinonome, Satomi, Yoshida, Hiroshi, Haruna, Miya, Miwa, Hiroto, Chatani, Natsumi, Ohkura, Naganari, Wada, Hisashi, Tanaka, Hidekazu
Publicado 2023

Discovery and Preclinical Characterization of XMT-1660, an Optimized B7-H4-Targeted Antibody–Drug Conjugate for the Treatment of Cancer

por Toader, Dorin, Fessler, Shawn P., Collins, Scott D., Conlon, Patrick R., Bollu, Reddy, Catcott, Kalli C., Chin, Chen-Ni, Dirksen, Anouk, Du, Bingfan, Duvall, Jeremy R., Higgins, Stacy, Kozytska, Mariya V., Bellovoda, Kamela, Faircloth, Chelsey, Lee, David, Li, Fu, Qin, Liuliang, Routhier, Caitlin, Shaw, Pamela, Stevenson, Cheri A., Wang, Jason, Wongthida, Phonphimon, Ter-Ovanesyan, Elena, Ditty, Elizabeth, Bradley, Stephen P., Xu, Ling, Yin, Mao, Yurkovetskiy, Alexandr V., Mosher, Rebecca, Damelin, Marc, Lowinger, Timothy B.
Publicado 2023

AMT-562, a Novel HER3-targeting Antibody–Drug Conjugate, Demonstrates a Potential to Broaden Therapeutic Opportunities for HER3-expressing Tumors

por Weng, Weining, Meng, Tao, Pu, Junyi, Ma, Linjie, Shen, Yi, Wang, Zhaohui, Pan, Rong, Wang, Mingqiao, Chen, Caiwei, Wang, Lijun, Zhang, Jianjian, Zhou, Biao, Shao, Siyuan, Qian, Yu, Liu, Shuhui, Hu, Wenhao, Meng, Xun
Publicado 2023

A Targeted Thorium-227 Conjugate Demonstrates Efficacy in Preclinical Models of Acquired Drug Resistance and Combination Potential with Chemotherapeutics and Antiangiogenic Therapi...

por Zitzmann-Kolbe, Sabine, Kristian, Alexander, Zopf, Dieter, Kamfenkel, Claudia, Politz, Oliver, Ellingsen, Christine, Hilbig, Jochen, Juul, Mark U., Fonslet, Jesper, Nielsen, Carsten H., Schatz, Christoph A., Bjerke, Roger M., Cuthbertson, Alan S., Mumberg, Dominik, Hagemann, Urs B.
Publicado 2023

Upregulation of Somatostatin Receptor Type 2 Improves (177)Lu-DOTATATE Therapy in Receptor-Deficient Pancreatic Neuroendocrine Tumor Model

por Sharma, Rupali, Earla, Bhargav, Baidoo, Kwamena E., Zeiger, Martha A., Madigan, James P., Escorcia, Freddy E., Sadowski, Samira M.
Publicado 2023

PARP Inhibitors Effectively Reduce MAPK Inhibitor Resistant Melanoma Cell Growth and Synergize with MAPK Inhibitors through a Synthetic Lethal Interaction In Vitro and In Vivo

por Fröhlich, Lisa Marie, Niessner, Heike, Sauer, Birgit, Kämereit, Sofie, Chatziioannou, Eftychia, Riel, Simon, Sinnberg, Tobias, Schittek, Birgit
Publicado 2023

Single-cell Profiling Uncovers a Muc4-Expressing Metaplastic Gastric Cell Type Sustained by Helicobacter pylori-driven Inflammation

por O'Brien, Valerie P., Kang, Yuqi, Shenoy, Meera K., Finak, Greg, Young, William C., Dubrulle, Julien, Koch, Lisa, Rodriguez Martinez, Armando E., Williams, Jeffery, Donato, Elizabeth, Batra, Surinder K., Yeung, Cecilia C.S., Grady, William M., Koch, Meghan A., Gottardo, Raphael, Salama, Nina R.
Publicado 2023

Resistance to Selective FGFR Inhibitors in FGFR-Driven Urothelial Cancer

por Facchinetti, Francesco, Hollebecque, Antoine, Braye, Floriane, Vasseur, Damien, Pradat, Yoann, Bahleda, Rastislav, Pobel, Cédric, Bigot, Ludovic, Déas, Olivier, Florez Arango, Juan David, Guaitoli, Giorgia, Mizuta, Hayato, Combarel, David, Tselikas, Lambros, Michiels, Stefan, Nikolaev, Sergey I., Scoazec, Jean-Yves, Ponce-Aix, Santiago, Besse, Benjamin, Olaussen, Ken A., Loriot, Yohann, Friboulet, Luc
Publicado 2023

A Novel Autologous CAR-T Therapy, YTB323, with Preserved T-cell Stemness Shows Enhanced CAR T-cell Efficacy in Preclinical and Early Clinical Development

por Dickinson, Michael J., Barba, Pere, Jäger, Ulrich, Shah, Nirav N., Blaise, Didier, Briones, Javier, Shune, Leyla, Boissel, Nicolas, Bondanza, Attilio, Mariconti, Luisa, Marchal, Anne-Laure, Quinn, David S., Yang, Jennifer, Price, Andrew, Sohoni, Akash, Treanor, Louise M., Orlando, Elena J., Mataraza, Jennifer, Davis, Jaclyn, Lu, Darlene, Zhu, Xu, Engels, Boris, Moutouh-de Parseval, Laure, Brogdon, Jennifer L., Moschetta, Michele, Flinn, Ian W.
Publicado 2023

Sex-Biased T-cell Exhaustion Drives Differential Immune Responses in Glioblastoma

por Lee, Juyeun, Nicosia, Michael, Hong, Ellen S., Silver, Daniel J., Li, Cathy, Bayik, Defne, Watson, Dionysios C., Lauko, Adam, Kay, Kristen E., Wang, Sabrina Z., Johnson, Sadie, McGraw, Mary, Grabowski, Matthew M., Kish, Danielle D., Desai, Amar B., Goodman, Wendy A., Cameron, Scott J., Okada, Hideho, Valujskikh, Anna, Fairchild, Robert L., Ahluwalia, Manmeet S., Lathia, Justin D.
Publicado 2023

RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across FGFR2 Alterations and Resistance Mutations

por Subbiah, Vivek, Sahai, Vaibhav, Maglic, Dejan, Bruderek, Kamil, Touré, B. Barry, Zhao, Songping, Valverde, Roberto, O'Hearn, Patrick J., Moustakas, Demetri T., Schönherr, Heike, Gerami-Moayed, Nastaran, Taylor, Alexander M., Hudson, Brandi M., Houde, Damian J., Pal, Debjani, Foster, Lindsey, Gunaydin, Hakan, Ayaz, Pelin, Sharon, Dina A., Goyal, Lipika, Schram, Alison M., Kamath, Suneel, Sherwin, Cori Ann, Schmidt-Kittler, Oleg, Jen, Kai Yu, Ricard, Fabien, Wolf, Beni B., Shaw, David E., Bergstrom, Donald A., Watters, James, Casaletto, Jessica B.
Publicado 2023

Dynamic Glycoprotein Hyposialylation Promotes Chemotherapy Evasion and Metastatic Seeding of Quiescent Circulating Tumor Cell Clusters in Breast Cancer

por Dashzeveg, Nurmaa K., Jia, Yuzhi, Zhang, Youbin, Gerratana, Lorenzo, Patel, Priyam, Shajahan, Asif, Dandar, Tsogbadrakh, Ramos, Erika K., Almubarak, Hannah F., Adorno-Cruz, Valery, Taftaf, Rokana, Schuster, Emma J., Scholten, David, Sokolowski, Michael T., Reduzzi, Carolina, El-Shennawy, Lamiaa, Hoffmann, Andrew D., Manai, Maroua, Zhang, Qiang, D'Amico, Paolo, Azadi, Parastoo, Colley, Karen J., Platanias, Leonidas C., Shah, Ami N., Gradishar, William J., Cristofanilli, Massimo, Muller, William A., Cobb, Brian A., Liu, Huiping
Publicado 2023

Clinical Benefit of Autologous Stem Cell Transplantation for Patients with Multiple Myeloma Achieving Undetectable Minimal Residual Disease after Induction Treatment

por Liu, Jiahui, Yan, Wenqiang, Fan, Huishou, Xu, Jingyu, Li, Lingna, Du, Chenxing, Mao, Xuehan, Yan, Yuting, Xu, Yan, Sui, Weiwei, Deng, Shuhui, Yi, Shuhua, Anderson, Kenneth C., Qiu, Lugui, Zou, Dehui, An, Gang
Publicado 2023

Blood Leukocyte AHRR Methylation and Risk of Non–smoking-associated Cancer: A Case-cohort Study of Non–Hodgkin Lymphoma

por Dahl, Christina, Hvidtfeldt, Ulla A., Tjønneland, Anne, Guldberg, Per, Raaschou-Nielsen, Ole
Publicado 2023

A Druggable FOXA1-Glucocorticoid Receptor Transcriptional Axis Drives Tumor Growth in a Subset of Non-Small Cell Lung Cancer

por Dorso, M., Patel, Payal T., Pankov, Aleksandr, Boyer, Jacob A., Soni, Rajesh K., Del Priore, Isabella S., Hayatt, Omar, Kulick, Amanda, Hagen, Connor J., de Stanchina, Elisa, Junttila, Melissa R., Daemen, Anneleen, Friedman, Lori S., Hendrickson, Ronald C., Chandarlapaty, Sarat
Publicado 2023

Nanoparticle Delivery of Immunostimulatory Alu RNA for Cancer Immunotherapy

por Garland, Kyle M., Kwiatkowski, Alexander J., Tossberg, John T., Crooke, Philip S., Aune, Thomas M., Wilson, John T.
Publicado 2023

Effect of Test History at Ages 50–64 on Later Cervical Cancer Risk: A Population-based Case–control Study

por Kultalahti, Henric, Heinävaara, Sirpa, Sarkeala, Tytti, Pankakoski, Maiju
Publicado 2023

Surgical Inflammation Alters Immune Response to Intraoperative Photodynamic Therapy

por Davis, Richard W., Klampatsa, Astero, Cramer, Gwendolyn M., Kim, Michele M., Miller, Joann M., Yuan, Min, Houser, Cassandra, Snyder, Emma, Putt, Mary, Vinogradov, Sergei A., Albelda, Steven M., Cengel, Keith A., Busch, Theresa M.
Publicado 2023

Association of Employment Disruptions and Financial Hardship Among Individuals Diagnosed with Cancer in the United States: Findings from a Nationally Representative Study

por Halpern, Michael T., de Moor, Janet S., Han, Xuesong, Zhao, Jingxuan, Zheng, Zhiyuan, Yabroff, K. Robin
Publicado 2023

Serum Free Fatty Acid Changes Caused by High Expression of Stearoyl-CoA Desaturase 1 in Tumor Tissues Are Early Diagnostic Markers for Ovarian Cancer

por Katoh, Kanoko, Katoh, Yuki, Kubo, Akiko, Iida, Miho, Ikeda, Yuji, Iwata, Takashi, Nishio, Hiroshi, Sugawara, Masaki, Kato, Daiki, Suematsu, Makoto, Hirai, Shuichi, Kawana, Kei
Publicado 2023