A Phase I Study of the Pan-Notch Inhibitor CB-103 for Patients with Advanced Adenoid Cystic Carcinoma and Other Tumors

por Hanna, Glenn J., Stathis, Anastasios, Lopez-Miranda, Elena, Racca, Fabricio, Quon, Doris, Leyvraz, Serge, Hess, Dagmar, Keam, Bhumsuk, Rodon, Jordi, Ahn, Myung-Ju, Kim, Hye Ryun, Schneeweiss, Andreas, Ribera, Josep-Maria, DeAngelo, Daniel, Perez Garcia, Jose Manuel, Cortes, Javier, Schönborn-Kellenberger, Oliver, Weber, Dirk, Pisa, Pavel, Bauer, Michael, Beni, Laura, Bobadilla, Maria, Lehal, Raj, Vigolo, Michele, Vogl, Florian D., Garralda, Elena
Publicado 2023

Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer

por Maron, Steven B., Chatila, Walid, Walch, Henry, Chou, Joanne F., Ceglia, Nicholas, Ptashkin, Ryan, Do, Richard Kinh Gian, Paroder, Viktoriya, Pandit-Taskar, Neeta, Lewis, Jason S., Biachi De Castria, Tiago, Sabwa, Shalom, Socolow, Fiona, Feder, Lara, Thomas, Jasmine, Schulze, Isabell, Kim, Kwanghee, Elzein, Arijh, Bojilova, Viktoria, Zatzman, Matthew, Bhanot, Umesh, Nagy, Rebecca J., Lee, Jeeyun, Simmons, Marc, Segal, Michal, Ku, Geoffrey Yuyat, Ilson, David H., Capanu, Marinela, Hechtman, Jaclyn F., Merghoub, Taha, Shah, Sohrab, Schultz, Nikolaus, Solit, David B., Janjigian, Yelena Y.
Publicado 2023

A Phase I, Multicenter, Open-Label, First-in-Human Study of DS-6157a in Patients with Advanced Gastrointestinal Stromal Tumor

por George, Suzanne, Heinrich, Michael C., Somaiah, Neeta, Oppelt, Peter, McLeod, Robert, Nishioka, Satoshi, Kundu, Madan G., Qian, Xiaozhong, Kumar, Prasanna, Laadem, Abderrahmane, Lau, Yvonne, Tran, Brittany P., Fallon, Maura, Dosunmu, Ololade, Shi, Julia, Naito, Yoichi
Publicado 2023

Dual Inhibition of KRAS(G12D) and Pan-ERBB Is Synergistic in Pancreatic Ductal Adenocarcinoma

por Gulay, Kevin Christian Montecillo, Zhang, Xinlian, Pantazopoulou, Vasiliki, Patel, Jay, Esparza, Edgar, Pran Babu, Deepa Sheik, Ogawa, Satoshi, Weitz, Jonathan, Ng, Isabella, Mose, Evangeline S., Pu, Minya, Engle, Dannielle D., Lowy, Andrew M., Tiriac, Hervé
Publicado 2023

ESRRB Inhibits the TGFβ Signaling Pathway to Drive Cell Proliferation in Cervical Cancer

por Li, Qin-Shu, Zheng, Peng-Sheng
Publicado 2023

CD25(high) Effector Regulatory T Cells Hamper Responses to PD-1 Blockade in Triple-Negative Breast Cancer

por Fattori, Stéphane, Le Roy, Aude, Houacine, Jemila, Robert, Lucie, Abes, Riad, Gorvel, Laurent, Granjeaud, Samuel, Rouvière, Marie-Sarah, Ben Amara, Amira, Boucherit, Nicolas, Tarpin, Carole, Pakradouni, Jihane, Charafe-Jauffret, Emmanuelle, Houvenaeghel, Gilles, Lambaudie, Eric, Bertucci, François, Rochigneux, Philippe, Gonçalves, Anthony, Foussat, Arnaud, Chrétien, Anne-Sophie, Olive, Daniel
Publicado 2023

Mutant KRAS Mediates circARFGEF2 Biogenesis to Promote Lymphatic Metastasis of Pancreatic Ductal Adenocarcinoma

por Kong, Yao, Luo, Yuming, Zheng, Shangyou, Yang, Jiabin, Zhang, Dingwen, Zhao, Yue, Zheng, Hanhao, An, Mingjie, Lin, Yan, Ai, Le, Diao, Xiayao, Lin, Qing, Chen, Changhao, Chen, Rufu
Publicado 2023

Transcriptomic Signatures of MSI-High Metastatic Colorectal Cancer Predict Efficacy of Immune Checkpoint Inhibitors

por Gallois, Claire, Landi, Matteo, Taieb, Julien, Sroussi, Marine, Saberzadeh-Ardestani, Bahar, Cazelles, Antoine, Lonardi, Sara, Bergamo, Francesca, Intini, Rossana, Maddalena, Giulia, Pietrantonio, Filippo, Corti, Francesca, Ambrosini, Margherita, Martinetti, Antonia, Germani, Marco Maria, Boccaccio, Chiara, Vetere, Guglielmo, Mouillet-Richard, Sophie, de Reynies, Aurélien, Sinicrope, Frank A., Cremolini, Chiara, Laurent-Puig, Pierre
Publicado 2023

Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment

por Derry, Jonathan M.J., Burns, Connor, Frazier, Jason P., Beirne, Emily, Grenley, Marc, DuFort, Christopher C., Killingbeck, Emily, Leon, Michael, Williams, Claire, Gregory, Mark, Houlton, Jeffrey, Clayburgh, Daniel, Swiecicki, Paul, Huszar, Dennis, Berger, Allison, Klinghoffer, Richard A.
Publicado 2023

Lorazepam Stimulates IL6 Production and Is Associated with Poor Survival Outcomes in Pancreatic Cancer

por Cornwell, Abigail C., Tisdale, Arwen A., Venkat, Swati, Maraszek, Kathryn E., Alahmari, Abdulrahman A., George, Anthony, Attwood, Kristopher, George, Madison, Rempinski, Donald, Franco-Barraza, Janusz, Seshadri, Mukund, Parker, Mark D., Cortes Gomez, Eduardo, Fountzilas, Christos, Cukierman, Edna, Steele, Nina G., Feigin, Michael E.
Publicado 2023

Identifying Mechanisms of Resistance by Circulating Tumor DNA in EVOLVE, a Phase II Trial of Cediranib Plus Olaparib for Ovarian Cancer at Time of PARP Inhibitor Progression

por Lheureux, Stephanie, Prokopec, Stephenie D., Oldfield, Leslie E., Gonzalez-Ochoa, Eduardo, Bruce, Jeffrey P., Wong, Derek, Danesh, Arnavaz, Torti, Dax, Torchia, Jonathan, Fortuna, Alexander, Singh, Sharanjit, Irving, Matthew, Marsh, Kayla, Lam, Bernard, Speers, Vanessa, Yosifova, Aleksandra, Oaknin, Ana, Madariaga, Ainhoa, Dhani, Neesha C., Bowering, Valerie, Oza, Amit M., Pugh, Trevor J.
Publicado 2023

Development and Multicenter Case–Control Validation of Urinary Comprehensive Genomic Profiling for Urothelial Carcinoma Diagnosis, Surveillance, and Risk-Prediction

por Salari, Keyan, Sundi, Debasish, Lee, Jason J., Wu, Shulin, Wu, Chin-Lee, DiFiore, Gabrielle, Yan, Q. Robert, Pienkny, Andrew, Lee, Chi K., Oberlin, Daniel, Barme, Greg, Piser, Joel, Kahn, Robert, Collins, Edward, Phillips, Kevin G., Caruso, Vincent M., Goudarzi, Mahdi, Garcia-Ransom, Monica, Lentz, Peter S., Evans-Holm, Martha E., MacBride, Andrew R., Fischer, Daniel S., Haddadzadeh, Iden J., Mazzarella, Brian C., Gray, Joe W., Koppie, Theresa M., Bicocca, Vincent T., Levin, Trevor G., Lotan, Yair, Feldman, Adam S.
Publicado 2023

Oncogenic ASPM Is a Regulatory Hub of Developmental and Stemness Signaling in Cancers

por Tsai, Kelvin K., Bae, Byoung-Il, Hsu, Chung-Chi, Cheng, Li-Hsin, Shaked, Yuval
Publicado 2023

A Phase Ib Trial of AVID200, a TGFβ 1/3 Trap, in Patients with Myelofibrosis

por Mascarenhas, John, Migliaccio, Anna Rita, Kosiorek, Heidi, Bhave, Rupali, Palmer, Jeanne, Kuykendall, Andrew, Mesa, Ruben, Rampal, Raajit K., Gerds, Aaron T., Yacoub, Abdulraheem, Pettit, Kristen, Talpaz, Moshe, Komrokji, Rami, Kremyanskaya, Marina, Gonzalez, Agapito, Fabris, Frank, Johnson, Kathryn, Dougherty, Mikaela, McGovern, Erin, Arango Ossa, Juan, Domenico, Dylan, Farnoud, Noushin, Weinberg, Rona Singer, Kong, Amy, Najfeld, Vesna, Vannucchi, Alessandro Maria, Arciprete, Francesca, Zingariello, Maria, Falchi, Mario, Salama, Mohamed E., Mead-Harvey, Carolyn, Dueck, Amylou, Varricchio, Lilian, Hoffman, Ronald
Publicado 2023

Integrated Multimodal Analyses of DNA Damage Response and Immune Markers as Predictors of Response in Metastatic Triple-Negative Breast Cancer in the TNT Trial (NCT00532727)

por Tovey, Holly, Sipos, Orsolya, Parker, Joel S., Hoadley, Katherine A., Quist, Jelmar, Kernaghan, Sarah, Kilburn, Lucy, Salgado, Roberto, Loi, Sherene, Kennedy, Richard D., Roxanis, Ioannis, Gazinska, Patrycja, Pinder, Sarah E., Bliss, Judith, Perou, Charles M., Haider, Syed, Grigoriadis, Anita, Tutt, Andrew, Cheang, Maggie Chon U.
Publicado 2023

Poor Outcome in Postpartum Breast Cancer Patients Is Associated with Distinct Molecular and Immunologic Features

por Lefrère, Hanne, Moore, Kat, Floris, Giuseppe, Sanders, Joyce, Seignette, Iris M., Bismeijer, Tycho, Peters, Dennis, Broeks, Annegien, Hooijberg, Erik, Van Calsteren, Kristel, Neven, Patrick, Warner, Ellen, Peccatori, Fedro Alessandro, Loibl, Sibylle, Maggen, Charlotte, Han, Sileny N., Jerzak, Katarzyna J., Annibali, Daniela, Lambrechts, Diether, de Visser, Karin E., Wessels, Lodewyk, Lenaerts, Liesbeth, Amant, Frédéric
Publicado 2023

EphA2 Proteolytic Fragment as a Sensitive Diagnostic Biomarker for Very Early-stage Pancreatic Ductal Carcinoma

por Sato, Shinya, Nakagawa, Masatoshi, Terashima, Takeshi, Morinaga, Soichiro, Miyagi, Yohei, Yoshida, Eisaku, Yoshimura, Toru, Seiki, Motoharu, Kaneko, Shuichi, Ueno, Makoto, Yamashita, Taro, Koshikawa, Naohiko
Publicado 2023

Accelerating Cancer Histopathology Workflows with Chemical Imaging and Machine Learning

por Falahkheirkhah, Kianoush, Mukherjee, Sudipta S., Gupta, Sounak, Herrera-Hernandez, Loren, McCarthy, Michael R., Jimenez, Rafael E., Cheville, John C., Bhargava, Rohit
Publicado 2023

AKR1C3 Converts Castrate and Post-Abiraterone DHEA-S into Testosterone to Stimulate Growth of Prostate Cancer Cells via 5-Androstene-3β,17β-Diol

por Detlefsen, Andrea J., Mesaros, Clementina A., Duan, Ling, Penning, Trevor M.
Publicado 2023

Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment

por Amo-Aparicio, Jesus, Dominguez, Adrian, Atif, Shaikh M., Dinarello, Alberto, Azam, Tania, Alula, Kibrom M., Piper, Miles, Lieu, Christopher H., Lentz, Robert W., Leal, Alexis D., Bagby, Stacey M., Messersmith, Wells A., Karam, Sana D., Dinarello, Charles A., Pitts, Todd M., Marchetti, Carlo
Publicado 2023