Sequential Exposure to IL21 and IL15 During Human Natural Killer Cell Expansion Optimizes Yield and Function

por Zhang, Caimei, Kadu, Siddhant, Xiao, Yansen, Johnson, Omar, Kelly, Andre, O'Connor, Roddy S., Lai, Meizan, Kong, Hong, Srivatsa, Sriram, Tai, Victoria, Greenblatt, Eli, Holmes, Matthew, Riley, James L., June, Carl H., Sheppard, Neil C.
Publicado 2023

EDIL3 as an Angiogenic Target of Immune Exclusion Following Checkpoint Blockade

por Tabasum, Saba, Thapa, Dinesh, Giobbie-Hurder, Anita, Weirather, Jason L., Campisi, Marco, Schol, Pieter J., Li, Xiaoyu, Li, Jingjing, Yoon, Charles H., Manos, Michael P., Barbie, David A., Hodi, F. Stephen
Publicado 2023

Exercise Training Reduces the Inflammatory Response and Promotes Intestinal Mucosa-Associated Immunity in Lynch Syndrome

por Deng, Nan, Reyes-Uribe, Laura, Fahrmann, Johannes F., Thoman, Whittney S., Munsell, Mark F., Dennison, Jennifer B., Murage, Eunice, Wu, Ranran, Hawk, Ernest T., Thirumurthi, Selvi, Lynch, Patrick M., Dieli-Conwright, Christina M., Lazar, Alexander J., Jindal, Sonali, Chu, Khoi, Chelvanambi, Manoj, Basen-Engquist, Karen, Li, Yisheng, Wargo, Jennifer A., McAllister, Florencia, Allison, James P., Sharma, Padmanee, Sinha, Krishna M., Hanash, Samir, Gilchrist, Susan C., Vilar, Eduardo
Publicado 2023

Genomic and Transcriptomic Landscape of an Oral Squamous Cell Carcinoma Mouse Model for Immunotherapy

por Lee, Yi-Mei, Hsu, Chia-Lang, Chen, Yu-Hsin, Ou, Da-Liang, Hsu, Chiun, Tan, Ching-Ting
Publicado 2023

Targeted Inhibition of lncRNA Malat1 Alters the Tumor Immune Microenvironment in Preclinical Syngeneic Mouse Models of Triple-Negative Breast Cancer

por Adewunmi, Oluwatoyosi, Shen, Yichao, Zhang, Xiang H.-F., Rosen, Jeffrey M.
Publicado 2023

Clinical and Molecular Features of Long-term Response to Immune Checkpoint Inhibitors in Patients with Advanced Non–Small Cell Lung Cancer

por Thummalapalli, Rohit, Ricciuti, Biagio, Bandlamudi, Chaitanya, Muldoon, Daniel, Rizvi, Hira, Elkrief, Arielle, Luo, Jia, Alessi, Joao V., Pecci, Federica, Lamberti, Giuseppe, Di Federico, Alessandro, Hong, Lingzhi, Zhang, Jianjun, Heymach, John V., Gibbons, Don L., Plodkowski, Andrew J., Ravichandran, Vignesh, Donoghue, Mark T.A., Vanderbilt, Chad, Ladanyi, Marc, Rudin, Charles M., Kris, Mark G., Riely, Gregory J., Chaft, Jamie E., Hellmann, Matthew D., Vokes, Natalie I., Awad, Mark M., Schoenfeld, Adam J.
Publicado 2023

Targeted Nanofitin-drug Conjugates Achieve Efficient Tumor Delivery and Therapeutic Effect in an EGFR(pos) Mouse Xenograft Model

por Huet, Simon, Zeisser Labouebe, Magali, Castro, Rute, Jacquot, Perrine, Pedrault, Jessy, Viollet, Sébastien, Van Simaeys, Gaetan, Doumont, Gilles, Larbanoix, Lionel, Zindy, Egor, Cunha, António E., Scapozza, Leonardo, Cinier, Mathieu
Publicado 2023

Updating the Definition of Cancer

por Brown, Joel S., Amend, Sarah R., Austin, Robert H., Gatenby, Robert A., Hammarlund, Emma U., Pienta, Kenneth J.
Publicado 2023

Epidemiology of Oral Human Papillomavirus Infection among Diverse Chinese Adults in Typical Areas of China: Findings from the DLCC Study

por Zhu, Yingying, He, Huijing, Zhu, Xiaoli, Hu, Yaoda, Yu, Shuting, Diao, Wenwen, Li, Shuguang, Shan, Guangliang, Chen, Xingming
Publicado 2023

Targeted Investigational Oncology Agents in the NCI-60: A Phenotypic Systems–based Resource

por Morris, Joel, Kunkel, Mark W., White, Stephen L., Wishka, Donn G., Lopez, Omar D., Bowles, Lori, Sellers Brady, Penny, Ramsey, Patricia, Grams, Julie, Rohrer, Tiffany, Martin, Karen, Dexheimer, Thomas S., Coussens, Nathan P., Evans, David, Risbood, Prabhakar, Sonkin, Dmitriy, Williams, John D., Polley, Eric C., Collins, Jerry M., Doroshow, James H., Teicher, Beverly A.
Publicado 2023

Combination Therapies to Improve the Efficacy of Immunotherapy in Triple-negative Breast Cancer

por Alečković, Maša, Li, Zheqi, Zhou, Ningxuan, Qiu, Xintao, Lulseged, Bethlehem, Foidart, Pierre, Huang, Xiao-Yun, Garza, Kodie, Shu, Shaokun, Kesten, Nikolas, Li, Rong, Lim, Klothilda, Garrido-Castro, Ana C., Guerriero, Jennifer L., Qi, Jun, Long, Henry W., Polyak, Kornelia
Publicado 2023

Kidney Function and Risk of Renal Cell Carcinoma

por Alcala, Karine, Zahed, Hana, Cortez Cardoso Penha, Ricardo, Alcala, Nicolas, Robbins, Hilary A., Smith-Byrne, Karl, Martin, Richard M., Muller, David C., Brennan, Paul, Johansson, Mattias
Publicado 2023

Fasting-Mimicking Diet Drives Antitumor Immunity against Colorectal Cancer by Reducing IgA-Producing Cells

por Zhong, Ziwen, Zhang, Hao, Nan, Ke, Zhong, Jing, Wu, Qichao, Lu, Lihong, Yue, Ying, Zhang, Zhenyu, Guo, Miaomiao, Wang, Zhiqiang, Xia, Jie, Xing, Yun, Fu, Ying, Yu, Baichao, Zhou, Wenchang, Sun, Xingfeng, Shen, Yang, Chen, Wankun, Zhang, Jie, Zhang, Jin, Ma, Duan, Chu, Yiwei, Liu, Ronghua, Miao, Changhong
Publicado 2023

Parkin Deficiency Suppresses Antigen Presentation to Promote Tumor Immune Evasion and Immunotherapy Resistance

por Perales-Linares, Renzo, Leli, Nektaria Maria, Mohei, Hesham, Beghi, Silvia, Rivera, Osvaldo D., Kostopoulos, Nektarios, Giglio, Andrea, George, Subin S., Uribe-Herranz, Mireia, Costabile, Francesca, Pierini, Stefano, Pustylnikov, Sergei, Skoufos, Giorgos, Barash, Yoseph, Hatzigeorgiou, Artemis G., Koumenis, Constantinos, Maity, Amit, Lotze, Michael T., Facciabene, Andrea
Publicado 2023

USP1 Expression Driven by EWS::FLI1 Transcription Factor Stabilizes Survivin and Mitigates Replication Stress in Ewing Sarcoma

por Mallard, Halle J., Wan, Shibiao, Nidhi, Prakriti, Hanscom-Trofy, Yvan D., Mohapatra, Bhopal, Woods, Nicholas T., Lopez-Guerrero, Jose Antonio, Llombart-Bosch, Antonio, Machado, Isidro, Scotlandi, Katia, Kreiling, Natasha F., Perry, Megan C., Mirza, Sameer, Coulter, Donald W., Band, Vimla, Band, Hamid, Ghosal, Gargi
Publicado 2023

DNA Methylation-Based Testing in Peripheral Blood Mononuclear Cells Enables Accurate and Early Detection of Colorectal Cancer

por Xie, Yan, Li, Peilong, Sun, Dong, Qi, Qiuchen, Ma, Suhong, Zhao, Yinghui, Zhang, Shujun, Wang, Tiantian, Wang, Jing, Li, Shijun, Gong, Tingting, Xu, Huiting, Xiong, Mengqiu, Li, Guanghua, You, Chongge, Luo, Zhaofan, Li, Juan, Wang, Chuanxin, Du, Lutao
Publicado 2023

Neoadjuvant Durvalumab Alone or Combined with Novel Immuno-Oncology Agents in Resectable Lung Cancer: The Phase II NeoCOAST Platform Trial

por Cascone, Tina, Kar, Gozde, Spicer, Jonathan D., García-Campelo, Rosario, Weder, Walter, Daniel, Davey B., Spigel, David R., Hussein, Maen, Mazieres, Julien, Oliveira, Julio, Yau, Edwin H., Spira, Alexander I., Anagnostou, Valsamo, Mager, Raymond, Hamid, Oday, Cheng, Lin-Yang, Zheng, Ying, Blando, Jorge, Tan, Tze Heng, Surace, Michael, Rodriguez-Canales, Jaime, Gopalakrishnan, Vancheswaran, Sellman, Bret R., Grenga, Italia, Soo-Hoo, Yee, Kumar, Rakesh, McGrath, Lara, Forde, Patrick M.
Publicado 2023

Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases

por Zheng, Yannan, Zhou, Rui, Cai, Jianan, Yang, Nanyan, Wen, Zhaowei, Zhang, Zhihua, Sun, Huiying, Huang, Genjie, Guan, Yijin, Huang, Na, Shi, Min, Liao, Yulin, Bin, Jianping, Liao, Wangjun
Publicado 2023

Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways

por Venneti, Sriram, Kawakibi, Abed Rahman, Ji, Sunjong, Waszak, Sebastian M., Sweha, Stefan R., Mota, Mateus, Pun, Matthew, Deogharkar, Akash, Chung, Chan, Tarapore, Rohinton S., Ramage, Samuel, Chi, Andrew, Wen, Patrick Y., Arrillaga-Romany, Isabel, Batchelor, Tracy T., Butowski, Nicholas A., Sumrall, Ashley, Shonka, Nicole, Harrison, Rebecca A., de Groot, John, Mehta, Minesh, Hall, Matthew D., Daghistani, Doured, Cloughesy, Timothy F., Ellingson, Benjamin M., Beccaria, Kevin, Varlet, Pascale, Kim, Michelle M., Umemura, Yoshie, Garton, Hugh, Franson, Andrea, Schwartz, Jonathan, Jain, Rajan, Kachman, Maureen, Baum, Heidi, Burant, Charles F., Mottl, Sophie L., Cartaxo, Rodrigo T., John, Vishal, Messinger, Dana, Qin, Tingting, Peterson, Erik, Sajjakulnukit, Peter, Ravi, Karthik, Waugh, Alyssa, Walling, Dustin, Ding, Yujie, Xia, Ziyun, Schwendeman, Anna, Hawes, Debra, Yang, Fusheng, Judkins, Alexander R., Wahl, Daniel, Lyssiotis, Costas A., de la Nava, Daniel, Alonso, Marta M., Eze, Augustine, Spitzer, Jasper, Schmidt, Susanne V., Duchatel, Ryan J., Dun, Matthew D., Cain, Jason E., Jiang, Li, Stopka, Sylwia A., Baquer, Gerard, Regan, Michael S., Filbin, Mariella G., Agar, Nathalie Y.R., Zhao, Lili, Kumar-Sinha, Chandan, Mody, Rajen, Chinnaiyan, Arul, Kurokawa, Ryo, Pratt, Drew, Yadav, Viveka N., Grill, Jacques, Kline, Cassie, Mueller, Sabine, Resnick, Adam, Nazarian, Javad, Allen, Joshua E., Odia, Yazmin, Gardner, Sharon L., Koschmann, Carl
Publicado 2023

STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts

por Buckbinder, Leonard, St. Jean, David J., Tieu, Trang, Ladd, Brendon, Hilbert, Brendan, Wang, Weixue, Alltucker, Jacob T., Manimala, Samantha, Kryukov, Gregory V., Brooijmans, Natasja, Dowdell, Gregory, Jonsson, Philip, Huff, Michael, Guzman-Perez, Angel, Jackson, Erica L., Goncalves, Marcus D., Stuart, Darrin D.
Publicado 2023