A Cell Surface-Binding Antibody Atlas Nominates a MUC18-Directed Antibody–Drug Conjugate for Targeting Melanoma

por Shi, Jing, Jiao, Tao, Guo, Qian, Weng, Weining, Ma, Linjie, Zhang, Qing, Wang, Lijun, Zhang, Jianjian, Chen, Caiwei, Huang, Yaling, Wang, Mingqiao, Pan, Rong, Tang, Yanfang, Hu, Wenhao, Meng, Tao, Liu, Shu-Hui, Guo, Jun, Kong, Yan, Meng, Xun
Publicado 2023

Subclonal Somatic Copy-Number Alterations Emerge and Dominate in Recurrent Osteosarcoma

por Kinnaman, Michael D., Zaccaria, Simone, Makohon-Moore, Alvin, Arnold, Brian, Levine, Max F., Gundem, Gunes, Arango Ossa, Juan E., Glodzik, Dominik, Rodríguez-Sánchez, M. Irene, Bouvier, Nancy, Li, Shanita, Stockfisch, Emily, Dunigan, Marisa, Cobbs, Cassidy, Bhanot, Umesh K., You, Daoqi, Mullen, Katelyn, Melchor, Jerry P., Ortiz, Michael V., O'Donohue, Tara J., Slotkin, Emily K., Wexler, Leonard H., Dela Cruz, Filemon S., Hameed, Meera R., Glade Bender, Julia L., Tap, William D., Meyers, Paul A., Papaemmanuil, Elli, Kung, Andrew L., Iacobuzio-Donahue, Christine A.
Publicado 2023

Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma

por Gomez, Felicia, Fisk, Bryan, McMichael, Joshua F., Mosior, Matthew, Foltz, Jennifer A., Skidmore, Zachary L., Duncavage, Eric J., Miller, Christopher A., Abel, Haley, Li, Yi-Shan, Russler-Germain, David A., Krysiak, Kilannin, Watkins, Marcus P., Ramirez, Cody A., Schmidt, Alina, Martins Rodrigues, Fernanda, Trani, Lee, Khanna, Ajay, Wagner, Julia A., Fulton, Robert S., Fronick, Catrina C., O'Laughlin, Michelle D., Schappe, Timothy, Cashen, Amanda F., Mehta-Shah, Neha, Kahl, Brad S., Walker, Jason, Bartlett, Nancy L., Griffith, Malachi, Fehniger, Todd A., Griffith, Obi L.
Publicado 2023

Mathematical Modeling Identifies Optimum Palbociclib-fulvestrant Dose Administration Schedules for the Treatment of Patients with Estrogen Receptor–positive Breast Cancer

por Cheng, Yu-Chen, Stein, Shayna, Nardone, Agostina, Liu, Weihan, Ma, Wen, Cohen, Gabriella, Guarducci, Cristina, McDonald, Thomas O., Jeselsohn, Rinath, Michor, Franziska
Publicado 2023

Multifactorial Remodeling of the Cancer Immunopeptidome by IFNγ

por Newey, Alice, Yu, Lu, Barber, Louise J., Choudhary, Jyoti S., Bassani-Sternberg, Michal, Gerlinger, Marco
Publicado 2023

Concurrent Targeting of HDAC and PI3K to Overcome Phenotypic Heterogeneity of Castration-resistant and Neuroendocrine Prostate Cancers

por Zhang, Ailin, Lau, Nathan A., Wong, Alicia, Brown, Lisha G., Coleman, Ilsa M., De Sarkar, Navonil, Li, Dapei, DeLucia, Diana C., Labrecque, Mark P., Nguyen, Holly M., Conner, Jennifer L., Dumpit, Ruth F., True, Lawrence D., Lin, Daniel W., Corey, Eva, Alumkal, Joshi J., Nelson, Peter S., Morrissey, Colm, Lee, John K.
Publicado 2023

Exogenous Sequences in Tumors and Immune Cells (Exotic): A Tool for Estimating the Microbe Abundances in Tumor RNA-seq Data

por Hoyd, Rebecca, Wheeler, Caroline E., Liu, YunZhou, Jagjit Singh, Malvenderjit S., Muniak, Mitchell, Jin, Ning, Denko, Nicholas C., Carbone, David P., Mo, Xiaokui, Spakowicz, Daniel J.
Publicado 2023

Activation of Kras(G12D) in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma

por Chaudhary, Priyanka, Xu, Xia, Wang, Guangfang, Hoj, Jacob P., Rampersad, Rishi R., Asselin-Labat, Marie-Liesse, Ting, Stephanie, Kim, William, Tamayo, Pablo, Pendergast, Ann Marie, Onaitis, Mark W.
Publicado 2023

SIX4 Controls Anti-PD-1 Efficacy by Regulating STING Expression

por Liang, Beiyuan, Zhang, Evan H., Ye, Zhen, Storts, Hayden, Jin, Wei, Zheng, Xinru, Hylton, Hannah, Zaleski, Olivia, Xing, Xuanxuan, Miles, Wayne, Wang, Jing J.
Publicado 2023

Targeted Degradation of XIAP is Sufficient and Specific to Induce Apoptosis in MYCN-overexpressing High-risk Neuroblastoma

por Choo, Zhang'E, Koh, Xiaoying, Wong, Megan Rui En, Ashokan, Ruth Minothini, Ali Ahamed, Nurul Suhana Binte, Kang, CongBao, Kuick, Chik Hong, Chang, Kenneth Tou En, Larisch, Sarit, Loh, Amos Hong Pheng, Chen, Zhi Xiong
Publicado 2023

Physical Activity During Adolescence and Early-adulthood and Ovarian Cancer Among Women with a BRCA1 or BRCA2 Mutation

por Guyonnet, Emma, Kim, Shana J., Xia, Yue Yin, Giannakeas, Vasily, Lubinski, Jan, Randall Armel, Susan, Eisen, Andrea, Bordeleau, Louise, Eng, Charis, Olopade, Olufunmilayo I., Tung, Nadine, Foulkes, William D., Couch, Fergus J., Aeilts, Amber M., Narod, Steven A., Kotsopoulos, Joanne
Publicado 2023

CAR T-cell Design-dependent Remodeling of the Brain Tumor Immune Microenvironment Modulates Tumor-associated Macrophages and Anti-glioma Activity

por Haydar, Dalia, Ibañez-Vega, Jorge, Crawford, Jeremy Chase, Chou, Ching-Heng, Guy, Clifford S., Meehl, Michaela, Yi, Zhongzhen, Perry, Scott, Laxton, Jonathan, Cunningham, Trevor, Langfitt, Deanna, Vogel, Peter, DeRenzo, Christopher, Gottschalk, Stephen, Roussel, Martine F., Thomas, Paul G., Krenciute, Giedre
Publicado 2023

Microtubule-Targeting Combined with HDAC Inhibition Is a Novel Therapeutic Strategy for Diffuse Intrinsic Pontine Gliomas

por Ehteda, Anahid, Khan, Aaminah, Rajakumar, Gayathiri, Vanniasinghe, Anne S., Gopalakrishnan, Anjana, Liu, Jie, Tsoli, Maria, Ziegler, David S.
Publicado 2023

Preventive Treatment with PD-1 Antibody Increases Tissue-resident Memory T Cells Infiltration and Delays Esophageal Carcinogenesis

por Xiao, Zeru, Yan, Rui, Liu, Heshu, Huang, Xuying, Liang, Ziwei, An, Guangyu, Ge, Yang
Publicado 2023

AMPK Associates with Chromatin and Phosphorylates the TAF-1 Subunit of the Transcription Initiation Complex to Regulate Histone Gene Expression in ALL Cells

por Sun, Guangyan, Leclerc, Guy J., Chahar, Sanjay, Barredo, Julio C.
Publicado 2023

Pro-905, a Novel Purine Antimetabolite, Combines with Glutamine Amidotransferase Inhibition to Suppress Growth of Malignant Peripheral Nerve Sheath Tumor

por Lemberg, Kathryn M., Ali, Eunus S., Krecmerova, Marcela, Aguilar, Joanna Marie H., Alt, Jesse, Peters, Diane E., Zhao, Liang, Wu, Ying, Nuha, Naziba, Asara, John M., Staedtke, Verena, Pratilas, Christine A., Majer, Pavel, Rais, Rana, Ben-Sahra, Issam, Slusher, Barbara S.
Publicado 2023

m(6)A-Mediated Biogenesis of circDDIT4 Inhibits Prostate Cancer Progression by Sequestrating ELAVL1/HuR

por Kong, Zhe, Lu, Yali, Yang, Yue, Chang, Kun, Lin, Yan, Huang, Yan, Wang, Chenji, Zhang, Lu, Xu, Wei, Zhao, Shimin, Li, Yao
Publicado 2023

Anticancer Efficacy of KRAS(G12C) Inhibitors Is Potentiated by PAK4 Inhibitor KPT9274 in Preclinical Models of KRAS(G12C)-Mutant Pancreatic and Lung Cancers

por Khan, Husain Yar, Nagasaka, Misako, Aboukameel, Amro, Alkhalili, Osama, Uddin, Md. Hafiz, Bannoura, Sahar F., Mzannar, Yousef, Azar, Ibrahim, Beal, Eliza W., Tobon, Miguel E., Kim, Steve H., Beydoun, Rafic, Baloglu, Erkan, Senapedis, William, El-Rayes, Bassel F., Philip, Philip A., Mohammad, Ramzi M., Shields, Anthony F., Al Hallak, Mohammed Najeeb, Azmi, Asfar S.
Publicado 2023

Ten-Patient Trial: Remarkable Responses in Pediatric Cancers

por Mardis, Elaine R.
Publicado 2023

The New NCI Precision Medicine Trials

por Harris, Lyndsay N., Blanke, Charles D., Erba, Harry P., Ford, James M., Gray, Robert J., LeBlanc, Michael L., Hu-Lieskovan, Siwen, Litzow, Mark R., Luger, Selina M., Meric-Bernstam, Funda, O'Dwyer, Peter J., Othus, Megan K.D., Politi, Katerina, Shepherd, Lois E., Allegra, Carmen J., Chen, Helen X., Ivy, S. Percy, Korde, Larissa A., Little, Richard F., McShane, Lisa M., Moscow, Jeffrey A., Patton, David R., Thurin, Magdalena, Yee, Laura M., Doroshow, James H.
Publicado 2023