Plexin-A4 Mediates Cytotoxic T-cell Trafficking and Exclusion in Cancer

por Celus, Ward, Oliveira, Ana I., Rivis, Silvia, Van Acker, Heleen H., Landeloos, Ewout, Serneels, Jens, Cafarello, Sarah Trusso, Van Herck, Yannick, Mastrantonio, Roberta, Köhler, Arnaud, Garg, Abhishek D., Flamand, Véronique, Tamagnone, Luca, Marine, Jean-Christophe, Matteo, Mario Di, Costa, Bruno M., Bechter, Oliver, Mazzone, Massimiliano
Publicado 2022

T Cells Promote Metastasis by Regulating Extracellular Matrix Remodeling following Chemotherapy

por Haj-Shomaly, Jozafina, Vorontsova, Avital, Barenholz-Cohen, Tamar, Levi-Galibov, Oshrat, Devarasetty, Mahesh, Timaner, Michael, Raviv, Ziv, Cooper, Tim J., Soker, Shay, Hasson, Peleg, Weihs, Daphne, Scherz-Shouval, Ruth, Shaked, Yuval
Publicado 2022

Repurposing Vandetanib plus Everolimus for the Treatment of ACVR1-Mutant Diffuse Intrinsic Pontine Glioma

por Carvalho, Diana M., Richardson, Peter J., Olaciregui, Nagore, Stankunaite, Reda, Lavarino, Cinzia, Molinari, Valeria, Corley, Elizabeth A., Smith, Daniel P., Ruddle, Ruth, Donovan, Adam, Pal, Akos, Raynaud, Florence I., Temelso, Sara, Mackay, Alan, Overington, John P., Phelan, Anne, Sheppard, David, Mackinnon, Andrew, Zebian, Bassel, Al-Sarraj, Safa, Merve, Ashirwad, Pryce, Jeremy, Grill, Jacques, Hubank, Michael, Cruz, Ofelia, Morales La Madrid, Andres, Mueller, Sabine, Carcaboso, Angel M., Carceller, Fernando, Jones, Chris
Publicado 2022

An In Vivo CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression

por Scheidmann, Manuel C., Castro-Giner, Francesc, Strittmatter, Karin, Krol, Ilona, Paasinen-Sohns, Aino, Scherrer, Ramona, Donato, Cinzia, Gkountela, Sofia, Szczerba, Barbara M., Diamantopoulou, Zoi, Muenst, Simone, Vlajnic, Tatjana, Kunz, Leo, Vetter, Marcus, Rochlitz, Christoph, Taylor, Verdon, Giachino, Claudio, Schroeder, Timm, Platt, Randall J., Aceto, Nicola
Publicado 2022

Local Treatment of a Pediatric Osteosarcoma Model with a 4-1BBL Armed Oncolytic Adenovirus Results in an Antitumor Effect and Leads to Immune Memory

por Martinez-Velez, Naiara, Laspidea, Virginia, Zalacain, Marta, Labiano, Sara, García-Moure, Marc, Puigdelloses, Montse, Marrodan, Lucía, Gonzalez-Huarriz, Marisol, Herrador, Guillermo, de la Nava, Daniel, Ausejo-Mauleon, Iker, Fueyo, Juan, Gomez-Manzano, Candelaria, Patiño-García, Ana, Alonso, Marta M.
Publicado 2022

Cancer-Associated SF3B1 Mutations Confer a BRCA-Like Cellular Phenotype and Synthetic Lethality to PARP Inhibitors

por Lappin, Katrina M., Barros, Eliana M., Jhujh, Satpal S., Irwin, Gareth W., McMillan, Hayley, Liberante, Fabio G., Latimer, Cheryl, La Bonte, Melissa J., Mills, Ken I., Harkin, D. Paul, Stewart, Grant S., Savage, Kienan I.
Publicado 2022

DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition

por Izquierdo, Elisa, Carvalho, Diana M., Mackay, Alan, Temelso, Sara, Boult, Jessica K.R., Pericoli, Giulia, Fernandez, Elisabet, Das, Molina, Molinari, Valeria, Grabovska, Yura, Rogers, Rebecca F., Ajmone-Cat, Maria Antonietta, Proszek, Paula Z., Stubbs, Mark, Depani, Sarita, O'Hare, Patricia, Yu, Lu, Roumelioti, Georgia, Choudhary, Jyoti S., Clarke, Matthew, Fairchild, Amy R., Jacques, Thomas S., Grundy, Richard G., Howell, Lisa, Picton, Susan, Adamski, Jenny, Wilson, Shaun, Gray, Juliet C., Zebian, Bassel, Marshall, Lynley V., Carceller, Fernando, Grill, Jacques, Vinci, Maria, Robinson, Simon P., Hubank, Michael, Hargrave, Darren, Jones, Chris
Publicado 2022

Assessing CSF ctDNA to Improve Diagnostic Accuracy and Therapeutic Monitoring in Breast Cancer Leptomeningeal Metastasis

por Fitzpatrick, Amanda, Iravani, Marjan, Mills, Adam, Childs, Lucy, Alaguthurai, Thanussuyah, Clifford, Angela, Garcia-Murillas, Isaac, Van Laere, Steven, Dirix, Luc, Harries, Mark, Okines, Alicia, Turner, Nicholas C., Haider, Syed, Tutt, Andrew N.J., Isacke, Clare M.
Publicado 2022

Impact of Duration of Neoadjuvant Aromatase Inhibitors on Molecular Expression Profiles in Estrogen Receptor–positive Breast Cancers

por Bergamino, Milana A., Morani, Gabriele, Parker, Joel, Schuster, Eugene F., Leal, Mariana F., López-Knowles, Elena, Tovey, Holly, Bliss, Judith M., Robertson, John F.R., Smith, Ian E., Dowsett, Mitch, Cheang, Maggie C.U.
Publicado 2022

Prognostic and Predictive Value of HER2 Expression in Ductal Carcinoma In Situ: Results from the UK/ANZ DCIS Randomized Trial

por Thorat, Mangesh A., Levey, Pauline M., Jones, J. Louise, Pinder, Sarah E., Bundred, Nigel J., Fentiman, Ian S., Cuzick, Jack
Publicado 2021

Overcoming CAR-Mediated CD19 Downmodulation and Leukemia Relapse with T Lymphocytes Secreting Anti-CD19 T-cell Engagers

por Blanco, Belén, Ramírez-Fernández, Ángel, Bueno, Clara, Argemí-Muntadas, Lidia, Fuentes, Patricia, Aguilar-Sopeña, Óscar, Gutierrez-Agüera, Francisco, Zanetti, Samanta Romina, Tapia-Galisteo, Antonio, Díez-Alonso, Laura, Segura-Tudela, Alejandro, Castellà, Maria, Marzal, Berta, Betriu, Sergi, Harwood, Seandean L., Compte, Marta, Lykkemark, Simon, Erce-Llamazares, Ainhoa, Rubio-Pérez, Laura, Jiménez-Reinoso, Anaïs, Domínguez-Alonso, Carmen, Neves, Maria, Morales, Pablo, Paz-Artal, Estela, Guedan, Sonia, Sanz, Laura, Toribio, María L., Roda-Navarro, Pedro, Juan, Manel, Menéndez, Pablo, Álvarez-Vallina, Luis
Publicado 2022

Genetic Screens Identify a Context-Specific PI3K/p27(Kip1) Node Driving Extrahepatic Biliary Cancer

por Falcomatà, Chiara, Bärthel, Stefanie, Ulrich, Angelika, Diersch, Sandra, Veltkamp, Christian, Rad, Lena, Boniolo, Fabio, Solar, Myriam, Steiger, Katja, Seidler, Barbara, Zukowska, Magdalena, Madej, Joanna, Wang, Mingsong, Öllinger, Rupert, Maresch, Roman, Barenboim, Maxim, Eser, Stefan, Tschurtschenthaler, Markus, Mehrabi, Arianeb, Roessler, Stephanie, Goeppert, Benjamin, Kind, Alexander, Schnieke, Angelika, Robles, Maria S., Bradley, Allan, Schmid, Roland M., Schmidt-Supprian, Marc, Reichert, Maximilian, Weichert, Wilko, Sansom, Owen J., Morton, Jennifer P., Rad, Roland, Schneider, Günter, Saur, Dieter
Publicado 2021

Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy

por Wu, Hsin-Chieh, Rérolle, Domitille, Berthier, Caroline, Hleihel, Rita, Sakamoto, Takashi, Quentin, Samuel, Benhenda, Shirine, Morganti, Claudia, Wu, Chengchen, Conte, Lidio, Rimsky, Sylvie, Sebert, Marie, Clappier, Emmanuelle, Souquere, Sylvie, Gachet, Stéphanie, Soulier, Jean, Durand, Sylvère, Trowbridge, Jennifer J., Bénit, Paule, Rustin, Pierre, El Hajj, Hiba, Raffoux, Emmanuel, Ades, Lionel, Itzykson, Raphael, Dombret, Hervé, Fenaux, Pierre, Espeli, Olivier, Kroemer, Guido, Brunetti, Lorenzo, Mak, Tak W., Lallemand-Breitenbach, Valérie, Bazarbachi, Ali, Falini, Brunangelo, Ito, Keisuke, Martelli, Maria Paola, de Thé, Hugues
Publicado 2021

Linking Physical Activity to Breast Cancer via Sex Steroid Hormones, Part 2: The Effect of Sex Steroid Hormones on Breast Cancer Risk

por Drummond, Ann E., Swain, Christopher T.V., Brown, Kristy A., Dixon-Suen, Suzanne C., Boing, Leonessa, van Roekel, Eline H., Moore, Melissa M., Gaunt, Tom R., Milne, Roger L., English, Dallas R., Martin, Richard M., Lewis, Sarah J., Lynch, Brigid M.
Publicado 2022

Tumor-Derived Lactic Acid Modulates Activation and Metabolic Status of Draining Lymph Node Stroma

por Riedel, Angela, Helal, Moutaz, Pedro, Luisa, Swietlik, Jonathan J., Shorthouse, David, Schmitz, Werner, Haas, Lisa, Young, Timothy, da Costa, Ana S.H., Davidson, Sarah, Bhandare, Pranjali, Wolf, Elmar, Hall, Benjamin A., Frezza, Christian, Oskarsson, Thordur, Shields, Jacqueline D.
Publicado 2022

Functional Genomic Identification of Predictors of Sensitivity and Mechanisms of Resistance to Multivalent Second-Generation TRAIL-R2 Agonists

por Grinkevitch, Vera, Wappett, Mark, Crawford, Nyree, Price, Stacey, Lees, Andrea, McCann, Christopher, McAllister, Katherine, Prehn, Jochen, Young, Jamie, Bateson, Jess, Gallagher, Lewis, Michaut, Magali, Iyer, Vivek, Chatzipli, Aikaterini, Barthorpe, Syd, Ciznadija, Daniel, Sloma, Ido, Wesa, Amy, Tice, David A., Wessels, Lodewyk, Garnett, Mathew, Longley, Daniel B., McDermott, Ultan, McDade, Simon S.
Publicado 2022

HER2 Mediates PSMA/mGluR1-Driven Resistance to the DS-7423 Dual PI3K/mTOR Inhibitor in PTEN Wild-type Prostate Cancer Models

por Gómez, Valentí, Galazi, Myria, Weitsman, Gregory, Monypenny, James, Al-Salemee, Fahad, Barber, Paul R., Ng, Kenrick, Beatson, Richard, Szokol, Bálint, Orfi, László, Mullen, Greg, Vanhaesebroeck, Bart, Chowdhury, Simon, Leung, Hing Y., Ng, Tony
Publicado 2022

Linking Physical Activity to Breast Cancer via Sex Hormones, Part 1: The Effect of Physical Activity on Sex Steroid Hormones

por Swain, Christopher T.V., Drummond, Ann E., Boing, Leonessa, Milne, Roger L., English, Dallas R., Brown, Kristy A., van Roekel, Eline H., Dixon-Suen, Suzanne C., Lynch, Michael J., Moore, Melissa M., Gaunt, Tom R., Martin, Richard M., Lewis, Sarah J., Lynch, Brigid M.
Publicado 2022

Tumor ENPP1 (CD203a)/Haptoglobin Axis Exploits Myeloid-Derived Suppressor Cells to Promote Post-Radiotherapy Local Recurrence in Breast Cancer

por Ruiz-Fernández de Córdoba, Borja, Moreno, Haritz, Valencia, Karmele, Perurena, Naiara, Ruedas, Pablo, Walle, Thomas, Pezonaga-Torres, Alberto, Hinojosa, Juan, Guruceaga, Elisabet, Pineda-Lucena, Antonio, Abengózar-Muela, Marta, Cochonneau, Denis, Zandueta, Carolina, Martínez-Canarias, Susana, Teijeira, Álvaro, Ajona, Daniel, Ortiz-Espinosa, Sergio, Morales, Xabier, Ortiz de Solórzano, Carlos, Santisteban, Marta, Ramos-García, Luis I., Guembe, Laura, Strnad, Vratislav, Heymann, Dominique, Hervás-Stubbs, Sandra, Pío, Rubén, Rodríguez-Ruiz, María E., de Andrea, Carlos E., Vicent, Silvestre, Melero, Ignacio, Lecanda, Fernando, Martínez-Monge, Rafael
Publicado 2022

The Genomic Landscape of Early-Stage Ovarian High-Grade Serous Carcinoma

por Cheng, Zhao, Mirza, Hasan, Ennis, Darren P., Smith, Philip, Morrill Gavarró, Lena, Sokota, Chishimba, Giannone, Gaia, Goranova, Theodora, Bradley, Thomas, Piskorz, Anna, Lockley, Michelle, Kaur, Baljeet, Singh, Naveena, Tookman, Laura A., Krell, Jonathan, McDermott, Jacqueline, Macintyre, Geoffrey, Markowetz, Florian, Brenton, James D., McNeish, Iain A.
Publicado 2022