Intracellular Acetyl CoA Potentiates the Therapeutic Efficacy of Antitumor CD8(+) T Cells

por Chowdhury, Snehanshu, Kar, Anwesha, Bhowmik, Debaleena, Gautam, Anupam, Basak, Debashree, Sarkar, Ishita, Ghosh, Puspendu, Sarkar, Deborpita, Deka, Alvina, Chakraborty, Paramita, Mukhopadhyay, Asima, Mehrotra, Shikhar, Basak, Soumen, Paul, Sandip, Chatterjee, Shilpak
Publicado 2022

Metabolomic Biomarkers in Blood Samples Identify Cancers in a Mixed Population of Patients with Nonspecific Symptoms

por Larkin, James R., Anthony, Susan, Johanssen, Vanessa A., Yeo, Tianrong, Sealey, Megan, Yates, Abi G., Smith, Claire Friedemann, Claridge, Timothy D.W., Nicholson, Brian D., Moreland, Julie-Ann, Gleeson, Fergus, Sibson, Nicola R., Anthony, Daniel C., Probert, Fay
Publicado 2022

Elevated Mutational Age in Blood of Children Treated for Cancer Contributes to Therapy-Related Myeloid Neoplasms

por Bertrums, Eline J.M., Rosendahl Huber, Axel K.M., de Kanter, Jurrian K., Brandsma, Arianne M., van Leeuwen, Anaïs J.C.N., Verheul, Mark, van den Heuvel-Eibrink, Marry M., Oka, Rurika, van Roosmalen, Markus J., de Groot-Kruseman, Hester A., Zwaan, C. Michel, Goemans, Bianca F., van Boxtel, Ruben
Publicado 2022

Integrated DNA and RNA Sequencing Reveals Drivers of Endocrine Resistance in Estrogen Receptor–Positive Breast Cancer

por Xia, Youli, He, Xiaping, Renshaw, Lorna, Martinez-Perez, Carlos, Kay, Charlene, Gray, Mark, Meehan, James, Parker, Joel S., Perou, Charles M., Carey, Lisa A., Dixon, J. Michael, Turnbull, Arran
Publicado 2022

Loss of the Volume-regulated Anion Channel Components LRRC8A and LRRC8D Limits Platinum Drug Efficacy

por Widmer, Carmen A., Klebic, Ismar, Domanitskaya, Natalya, Decollogny, Morgane, Howald, Denise, Siffert, Myriam, Essers, Paul, Nowicka, Zuzanna, Stokar-Regenscheit, Nadine, van de Ven, Marieke, de Korte-Grimmerink, Renske, Galván, José A., Pritchard, Colin E.J., Huijbers, Ivo J., Fendler, Wojciech, Vens, Conchita, Rottenberg, Sven
Publicado 2022

Inhibiting ERK5 Overcomes Breast Cancer Resistance to Anti-HER2 Therapy By Targeting the G(1)–S Cell-Cycle Transition

por Zhang, Jingwei, Pearson, Adam J., Sabherwal, Nitin, Telfer, Brian A., Ali, Nisha, Kan, Karmern, Xu, Qiuping, Zhang, Wei, Chen, Fuhui, Li, Shiyang, Wang, Jinhua, Gray, Nathanael S., Risa-Ebrí, Blanca, Finegan, Katherine G., Cross, Michael J., Giurisato, Emanuele, Whitmarsh, Alan J., Tournier, Cathy
Publicado 2022

Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells

por Milutinovic, Stefan, Abe, Jun, Jones, Emma, Kelch, Inken, Smart, Kathryn, Lauder, Sarah N., Somerville, Michelle, Ware, Carl, Godkin, Andrew, Stein, Jens V., Bogle, Gib, Gallimore, Awen
Publicado 2022

Cellular Senescence Is Immunogenic and Promotes Antitumor Immunity

por Marin, Ines, Boix, Olga, Garcia-Garijo, Andrea, Sirois, Isabelle, Caballe, Adrià, Zarzuela, Eduardo, Ruano, Irene, Attolini, Camille Stephan-Otto, Prats, Neus, López-Domínguez, José A, Kovatcheva, Marta, Garralda, Elena, Muñoz, Javier, Caron, Etienne, Abad, María, Gros, Alena, Pietrocola, Federico, Serrano, Manuel
Publicado 2023

Boosting of Waned Humoral and Cellular Responses to SARS-CoV-2 Variants of Concern Among Patients with Cancer

por McKenzie, Duncan R., Graham, Rosalind, Lechmere, Thomas, Domingo-Vila, Clara, Alaguthurai, Thanussuyah, Arman, Celeste, Pollock, Emily, Gousis, Charalampos, Kakkassery, Helen, Carpenter, Esme, Kurshan, Ashwini, Vidler, Jennifer, Kulasekararaj, Austin, Patten, Piers, North, Bernard V., Tree, Timothy, Doores, Katie J., Hayday, Adrian C., Irshad, Sheeba
Publicado 2022

COVID-19 Infections and Clinical Outcomes in Patients with Multiple Myeloma in New York City: A Cohort Study from Five Academic Centers

por Hultcrantz, Malin, Richter, Joshua, Rosenbaum, Cara A., Patel, Dhwani, Smith, Eric L., Korde, Neha, Lu, Sydney X., Mailankody, Sham, Shah, Urvi A., Lesokhin, Alexander M., Hassoun, Hani, Tan, Carlyn, Maura, Francesco, Derkach, Andriy, Diamond, Benjamin, Rossi, Adriana, Pearse, Roger N., Madduri, Deepu, Chari, Ajai, Kaminetzky, David, Braunstein, Marc J., Gordillo, Christian, Reshef, Ran, Taur, Ying, Davies, Faith E., Jagannath, Sundar, Niesvizky, Ruben, Lentzsch, Suzanne, Morgan, Gareth J., Landgren, Ola
Publicado 2020

Quantitative Analysis of Tyrosine Phosphorylation from FFPE Tissues Reveals Patient-Specific Signaling Networks

por Kohale, Ishwar N., Burgenske, Danielle M., Mladek, Ann C., Bakken, Katrina K., Kuang, Jenevieve, Boughey, Judy C., Wang, Liewei, Carter, Jodi M., Haura, Eric B., Goetz, Matthew P., Sarkaria, Jann N., White, Forest M.
Publicado 2021

Evaluation of the Small-molecule BRD4 Degrader CFT-2718 in Small-cell Lung Cancer and Pancreatic Cancer Models

por Sun, Danlin, Nikonova, Anna S., Zhang, Peishan, Deneka, Alexander Y., Fitzgerald, Mark E., Michael, Ryan E., Lee, Linda, Lilly, Anna C., Fisher, Stewart L., Phillips, Andrew J., Nasveschuk, Christopher G., Proia, David A., Tu, Zhigang, Golemis, Erica A.
Publicado 2021

Oncolytic Vaccinia Virus Gene Modification and Cytokine Expression Effects on Tumor Infection, Immune Response, and Killing

por Inoue, Tomoyoshi, Byrne, Thomas, Inoue, Mitsuko, Tait, Madeline E., Wall, Patrick, Wang, Annabel, Dermyer, Michael R., Laklai, Hanane, Binder, Joseph J., Lees, Clare, Hollingsworth, Robert, Maruri-Avidal, Liliana, Kirn, David H., McDonald, Donald M.
Publicado 2021

Assessing Electronic Nicotine Delivery Systems Use at NCI-Designated Cancer Centers in the Cancer Moonshot–funded Cancer Center Cessation Initiative

por D'Angelo, Heather, Land, Stephanie R., Mayne, Rachel Grana
Publicado 2021

Local Anti–PD-1 Delivery Prevents Progression of Premalignant Lesions in a 4NQO-Oral Carcinogenesis Mouse Model

por Shi, Yewen, Xie, Tong-xin, Leach, David G., Wang, Bingbing, Young, Simon, Osman, Abdullah A., Sikora, Andrew G., Ren, Xiaoyong, Hartgerink, Jeffrey D., Myers, Jeffrey N., Rangel, Roberto
Publicado 2021

The Ratio of Toxic-to-Nontoxic miRNAs Predicts Platinum Sensitivity in Ovarian Cancer

por Patel, Monal, Wang, Yinu, Bartom, Elizabeth T., Dhir, Rohin, Nephew, Kenneth P., Matei, Daniela, Murmann, Andrea E., Lengyel, Ernst, Peter, Marcus E.
Publicado 2021

Neutralization of PD-L2 is Essential for Overcoming Immune Checkpoint Blockade Resistance in Ovarian Cancer

por Miao, Yu Rebecca, Thakkar, Kaushik N., Qian, Jin, Kariolis, Mihalis S., Huang, Wei, Nandagopal, Saravanan, Yang, Teddy Tat Chi, Diep, Anh N., Cherf, Gerald Maxwell, Xu, Yu, Moon, Eui Jung, Xiao, Yiren, Alemany, Haizea, Li, Tiane, Yu, Wenhua, Wei, Bo, Rankin, Erinn B., Giaccia, Amato J.
Publicado 2021

Gene Fusions Create Partner and Collateral Dependencies Essential to Cancer Cell Survival

por Gillani, Riaz, Seong, Bo Kyung A., Crowdis, Jett, Conway, Jake R., Dharia, Neekesh V., Alimohamed, Saif, Haas, Brian J., Han, Kyuho, Park, Jihye, Dietlein, Felix, He, Meng Xiao, Imamovic, Alma, Ma, Clement, Bassik, Michael C., Boehm, Jesse S., Vazquez, Francisca, Gusev, Alexander, Liu, David, Janeway, Katherine A., McFarland, James M., Stegmaier, Kimberly, Van Allen, Eliezer M.
Publicado 2021

Therapeutic Synergy in Esophageal Cancer and Mesothelioma Is Predicted by Dynamic BH3 Profiling

por Surman, Deborah R., Xu, Yuan, Lee, Min-Jung, Trepel, Jane, Brown, Kate, Ramineni, Maheshwari, Splawn, Taylor G., Diggs, Laurence P., Hodges, H. Courtney, Davis, Jeremy L., Lee, Hyun-Sung, Burt, Bryan M., Ripley, Robert Taylor
Publicado 2021

Nuclear FGFR1 Regulates Gene Transcription and Promotes Antiestrogen Resistance in ER(+) Breast Cancer

por Servetto, Alberto, Kollipara, Rahul, Formisano, Luigi, Lin, Chang-Ching, Lee, Kyung-Min, Sudhan, Dhivya R., Gonzalez-Ericsson, Paula I., Chatterjee, Sumanta, Guerrero-Zotano, Angel, Mendiratta, Saurabh, Akamatsu, Hiroaki, James, Nicholas, Bianco, Roberto, Hanker, Ariella B., Kittler, Ralf, Arteaga, Carlos L.
Publicado 2021