Breast-Specific Molecular Clocks Comprised of ELF5 Expression and Promoter Methylation Identify Individuals Susceptible to Cancer Initiation

por Miyano, Masaru, Sayaman, Rosalyn W., Shalabi, Sundus F., Senapati, Parijat, Lopez, Jennifer C., Angarola, Brittany Lynn, Hinz, Stefan, Zirbes, Arrianna, Anczukow, Olga, Yee, Lisa D., Sedrak, Mina S., Stampfer, Martha R., Seewaldt, Victoria L., LaBarge, Mark A.
Publicado 2021

Mapping of m(6)A and Its Regulatory Targets in Prostate Cancer Reveals a METTL3-Low Induction of Therapy Resistance

por Cotter, Kellie A., Gallon, John, Uebersax, Nadine, Rubin, Philip, Meyer, Kate D., Piscuoglio, Salvatore, Jaffrey, Samie R., Rubin, Mark A.
Publicado 2021

Vorasidenib, a Dual Inhibitor of Mutant IDH1/2, in Recurrent or Progressive Glioma; Results of a First-in-Human Phase I Trial

por Mellinghoff, Ingo K., Penas-Prado, Marta, Peters, Katherine B., Burris, Howard A., Maher, Elizabeth A., Janku, Filip, Cote, Gregory M., de la Fuente, Macarena I., Clarke, Jennifer L., Ellingson, Benjamin M., Chun, Saewon, Young, Robert J., Liu, Hua, Choe, Sung, Lu, Min, Le, Kha, Hassan, Islam, Steelman, Lori, Pandya, Shuchi S., Cloughesy, Timothy F., Wen, Patrick Y.
Publicado 2021

NCI Imaging Data Commons

por Fedorov, Andrey, Longabaugh, William J.R., Pot, David, Clunie, David A., Pieper, Steve, Aerts, Hugo J.W.L., Homeyer, André, Lewis, Rob, Akbarzadeh, Afshin, Bontempi, Dennis, Clifford, William, Herrmann, Markus D., Höfener, Henning, Octaviano, Igor, Osborne, Chad, Paquette, Suzanne, Petts, James, Punzo, Davide, Reyes, Madelyn, Schacherer, Daniela P., Tian, Mi, White, George, Ziegler, Erik, Shmulevich, Ilya, Pihl, Todd, Wagner, Ulrike, Farahani, Keyvan, Kikinis, Ron
Publicado 2021

CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis

por Laine, Anni, Nagelli, Srikar G., Farrington, Caroline, Butt, Umar, Cvrljevic, Anna N., Vainonen, Julia P., Feringa, Femke M., Grönroos, Tove J., Gautam, Prson, Khan, Sofia, Sihto, Harri, Qiao, Xi, Pavic, Karolina, Connolly, Denise C., Kronqvist, Pauliina, Elo, Laura L., Maurer, Jochen, Wennerberg, Krister, Medema, Rene H., Joensuu, Heikki, Peuhu, Emilia, de Visser, Karin, Narla, Goutham, Westermarck, Jukka
Publicado 2021

Identification of a Novel Inflamed Tumor Microenvironment Signature as a Predictive Biomarker of Bacillus Calmette-Guérin Immunotherapy in Non–Muscle-Invasive Bladder Cancer

por Damrauer, Jeffrey S., Roell, Kyle R., Smith, Markia A., Sun, Xuezheng, Kirk, Erin L., Hoadley, Katherine A., Benefield, Halei C., Iyer, Gopakumar, Solit, David B., Milowsky, Matthew I., Kim, William Y., Nielsen, Matthew E., Wobker, Sara E., Dalbagni, Guido, Al-Ahmadie, Hikmat A., Olshan, Andrew F., Bochner, Bernard H., Furberg, Helena, Troester, Melissa A., Pietzak, Eugene J.
Publicado 2021

Change in Blood and Benign Breast Biomarkers in Women Undergoing a Weight-Loss Intervention Randomized to High-Dose ω-3 Fatty Acids versus Placebo

por Fabian, Carol J., Befort, Christie A., Phillips, Teresa A., Nydegger, Jennifer L., Kreutzjans, Amy L., Powers, Kandy R., Metheny, Trina, Klemp, Jennifer R., Carlson, Susan E., Sullivan, Debra K., Zalles, Carola M., Giles, Erin D., Hursting, Stephen D., Hu, Jinxiang, Kimler, Bruce F.
Publicado 2021

Fatty Acid Synthesis in Prostate Cancer: Vulnerability or Epiphenomenon?

por Sena, Laura A., Denmeade, Samuel R.
Publicado 2021

Memory-like Differentiation Enhances NK Cell Responses to Melanoma

por Marin, Nancy D., Krasnick, Bradley A., Becker-Hapak, Michelle, Conant, Leah, Goedegebuure, Simon P., Berrien-Elliott, Melissa M., Robbins, Keenan J., Foltz, Jennifer A., Foster, Mark, Wong, Pamela, Cubitt, Celia C., Tran, Jennifer, Wetzel, Christopher B., Jacobs, Miriam, Zhou, Alice Y., Russler-Germain, David, Marsala, Lynne, Schappe, Timothy, Fields, Ryan C., Fehniger, Todd A.
Publicado 2021

Development of a Novel Mouse Model of Spontaneous High-Risk HPVE6/E7–Expressing Carcinoma in the Cervicovaginal Tract

por Henkle, Talia R., Lam, Brandon, Kung, Yu Jui, Lin, John, Tseng, Ssu-Hsueh, Ferrall, Louise, Xing, Deyin, Hung, Chien-Fu, Wu, T.-C.
Publicado 2021

RASAL2 Confers Collateral MEK/EGFR Dependency in Chemoresistant Triple-Negative Breast Cancer

por Koh, Siang-Boon, Ross, Kenneth, Isakoff, Steven J., Melkonjan, Nsan, He, Lei, Matissek, Karina J., Schultz, Andrew, Mayer, Erica L., Traina, Tiffany A., Carey, Lisa A., Rugo, Hope S., Liu, Minetta C., Stearns, Vered, Langenbucher, Adam, Saladi, Srinivas Vinod, Ramaswamy, Sridhar, Lawrence, Michael S., Ellisen, Leif W.
Publicado 2021

BET Bromodomain Inhibition Blocks an AR-Repressed, E2F1-Activated Treatment-Emergent Neuroendocrine Prostate Cancer Lineage Plasticity Program

por Kim, Dae-Hwan, Sun, Duanchen, Storck, William K., Welker Leng, Katherine, Jenkins, Chelsea, Coleman, Daniel J., Sampson, David, Guan, Xiangnan, Kumaraswamy, Anbarasu, Rodansky, Eva S., Urrutia, Joshua A., Schwartzman, Jacob A., Zhang, Chao, Beltran, Himisha, Labrecque, Mark P., Morrissey, Colm, Lucas, Jared M., Coleman, Ilsa M., Nelson, Peter S., Corey, Eva, Handelman, Samuel K., Sexton, Jonathan Z., Aggarwal, Rahul, Abida, Wassim, Feng, Felix Y., Small, Eric J., Spratt, Daniel E., Bankhead, Armand, Rao, Arvind, Gesner, Emily M., Attwell, Sarah, Lakhotia, Sanjay, Campeau, Eric, Yates, Joel A., Xia, Zheng, Alumkal, Joshi J.
Publicado 2021

Reducing Skin Toxicities from EGFR Inhibitors with Topical BRAF Inhibitor Therapy

por Lacouture, Mario E., Wainberg, Zev A., Patel, Anisha B., Anadkat, Milan J., Stemmer, Salomon M., Shacham-Shmueli, Einat, Medina, Egmidio, Zelinger, Galit, Shelach, Noa, Ribas, Antoni
Publicado 2021

Defining the Energetic Basis for a Conformational Switch Mediating Ligand-Independent Activation of Mutant Estrogen Receptors in Breast Cancer

por Mayne, Christopher G., Toy, Weiyi, Carlson, Kathryn E., Bhatt, Trusha, Fanning, Sean W., Greene, Geoffrey L., Katzenellenbogen, Benita S., Chandarlapaty, Sarat, Katzenellenbogen, John A., Tajkhorshid, Emad
Publicado 2021

ONC212 is a Novel Mitocan Acting Synergistically with Glycolysis Inhibition in Pancreatic Cancer

por Ferrarini, Isacco, Louie, Anna, Zhou, Lanlan, El-Deiry, Wafik S.
Publicado 2021

Development of a High-throughput NanoBRET Screening Platform to Identify Modulators of the RAS/RAF Interaction

por Durrant, David E., Smith, Emily A., Goncharova, Ekaterina I., Sharma, Nirmala, Alexander, Patrick A., Stephen, Andrew G., Henrich, Curtis J., Morrison, Deborah K.
Publicado 2021

VLX600 Disrupts Homologous Recombination and Synergizes with PARP Inhibitors and Cisplatin by Inhibiting Histone Lysine Demethylases

por Ekstrom, Thomas L., Pathoulas, Nicholas M., Huehls, Amelia M., Kanakkanthara, Arun, Karnitz, Larry M.
Publicado 2021

Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB–Mediated Production of CXCL1

por Kemp, Samantha B., Carpenter, Eileen S., Steele, Nina G., Donahue, Katelyn L., Nwosu, Zeribe C., Pacheco, Amanda, Velez-Delgado, Ashley, Menjivar, Rosa E., Lima, Fatima, The, Stephanie, Espinoza, Carlos E., Brown, Kristee, Long, Daniel, Lyssiotis, Costas A., Rao, Arvind, Zhang, Yaqing, Pasca di Magliano, Marina, Crawford, Howard C.
Publicado 2021

Intracranial Efficacy of Selpercatinib in RET Fusion-Positive Non–Small Cell Lung Cancers on the LIBRETTO-001 Trial

por Subbiah, Vivek, Gainor, Justin F., Oxnard, Geoffrey R., Tan, Daniel S.W., Owen, Dwight H., Cho, Byoung Chul, Loong, Herbert H., McCoach, Caroline E., Weiss, Jared, Kim, Yu Jung, Bazhenova, Lyudmila, Park, Keunchil, Daga, Haruko, Besse, Benjamin, Gautschi, Oliver, Rolfo, Christian, Zhu, Edward Y., Kherani, Jennifer F., Huang, Xin, Kang, Suhyun, Drilon, Alexander
Publicado 2021

Identification and Validation of T-cell Receptors Targeting RAS Hotspot Mutations in Human Cancers for Use in Cell-based Immunotherapy

por Levin, Noam, Paria, Biman C., Vale, Nolan R., Yossef, Rami, Lowery, Frank J., Parkhurst, Maria R., Yu, Zhiya, Florentin, Maria, Cafri, Gal, Gartner, Jared J., Shindorf, Mackenzie L., Ngo, Lien T., Ray, Satyajit, Kim, Sanghyun P., Copeland, Amy R., Robbins, Paul F., Rosenberg, Steven A.
Publicado 2021