Lentiviral-Driven Discovery of Cancer Drug Resistance Mutations

por Yenerall, Paul, Kollipara, Rahul K., Avila, Kimberley, Peyton, Michael, Eide, Christopher A., Bottomly, Daniel, McWeeney, Shannon K., Liu, Yan, Westover, Kenneth D., Druker, Brian J., Minna, John D., Kittler, Ralf
Publicado 2021

Network Analysis Reveals Synergistic Genetic Dependencies for Rational Combination Therapy in Philadelphia Chromosome–Like Acute Lymphoblastic Leukemia

por Ding, Yang-Yang, Kim, Hannah, Madden, Kellyn, Loftus, Joseph P., Chen, Gregory M., Allen, David Hottman, Zhang, Ruitao, Xu, Jason, Chen, Chia-Hui, Hu, Yuxuan, Tasian, Sarah K., Tan, Kai
Publicado 2021

PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer

por Zhao, Zibo, Szczepanski, Aileen P., Tsuboyama, Natsumi, Abdala-Valencia, Hiam, Goo, Young Ah, Singer, Benjamin D., Bartom, Elizabeth T., Yue, Feng, Wang, Lu
Publicado 2021

Immune Profiling Mass Cytometry Assay Harmonization: Multicenter Experience from CIMAC-CIDC

por Sahaf, Bita, Pichavant, Mina, Lee, Brian H., Duault, Caroline, Thrash, Emily M., Davila, Melanie, Fernandez, Nicolas, Millerchip, Karen, Bentebibel, Salah-Eddine, Haymaker, Cara, Sigal, Natalia, Del Valle, Diane M., Ranasinghe, Srinika, Fayle, Sarah, Sanchez-Espiridion, Beatriz, Zhang, Jiexin, Bernatchez, Chantale, Wu, Catherine J., Wistuba, Ignacio I., Kim-Schulze, Seunghee, Gnjatic, Sacha, Bendall, Sean C., Song, Minkyung, Thurin, Magdalena, Lee, J. Jack, Maecker, Holden T., Rahman, Adeeb
Publicado 2021

PARP and CDK4/6 Inhibitor Combination Therapy Induces Apoptosis and Suppresses Neuroendocrine Differentiation in Prostate Cancer

por Wu, Cheng, Peng, Shan, Pilié, Patrick G., Geng, Chuandong, Park, Sanghee, Manyam, Ganiraju C., Lu, Yungang, Yang, Guang, Tang, Zhe, Kondraganti, Shakuntala, Wang, Daoqi, Hudgens, Courtney W., Ledesma, Debora A., Marques-Piubelli, Mario L., Torres-Cabala, Carlos A., Curry, Jonathan L., Troncoso, Patricia, Corn, Paul G., Broom, Bradley M., Thompson, Timothy C.
Publicado 2021

ATR Inhibition Induces CDK1–SPOP Signaling and Enhances Anti–PD-L1 Cytotoxicity in Prostate Cancer

por Tang, Zhe, Pilié, Patrick G., Geng, Chuandong, Manyam, Ganiraju C., Yang, Guang, Park, Sanghee, Wang, Daoqi, Peng, Shan, Wu, Cheng, Peng, Guang, Yap, Timothy A., Corn, Paul G., Broom, Bradley M., Thompson, Timothy C.
Publicado 2021

A Method for Overcoming Plasma Protein Inhibition of Tyrosine Kinase Inhibitors

por Young, David J., Nguyen, Bao, Li, Li, Higashimoto, Tomoyasu, Levis, Mark J., Liu, Jun O., Small, Donald
Publicado 2021

Discovery and Features of an Alkylating Signature in Colorectal Cancer

por Gurjao, Carino, Zhong, Rong, Haruki, Koichiro, Li, Yvonne Y., Spurr, Liam F., Lee-Six, Henry, Reardon, Brendan, Ugai, Tomotaka, Zhang, Xuehong, Cherniack, Andrew D., Song, Mingyang, Van Allen, Eliezer M., Meyerhardt, Jeffrey A., Nowak, Jonathan A., Giovannucci, Edward L., Fuchs, Charles S., Wu, Kana, Ogino, Shuji, Giannakis, Marios
Publicado 2021

Neuroblastoma Formation Requires Unconventional CD4 T Cells and Arginase-1–Dependent Myeloid Cells

por Van de Velde, Lee-Ann, Allen, E. Kaitlynn, Crawford, Jeremy Chase, Wilson, Taylor L., Guy, Clifford S., Russier, Marion, Zeitler, Leonie, Bahrami, Armita, Finkelstein, David, Pelletier, Stephane, Schultz-Cherry, Stacey, Thomas, Paul G., Murray, Peter J.
Publicado 2021

Breast Density Awareness and Knowledge in a Mammography Screening Cohort of Predominantly Hispanic Women: Does Breast Density Notification Matter?

por Austin, Jessica D., Agovino, Mariangela, Rodriguez, Carmen B., Terry, Mary Beth, Shelton, Rachel C., Wei, Ying, Desperito, Elise, Schmitt, Karen M., Kukafka, Rita, Tehranifar, Parisa
Publicado 2021

Hallmarks of RET and Co-occuring Genomic Alterations in RET-aberrant Cancers

por Adashek, Jacob J., Desai, Aakash P., Andreev-Drakhlin, Alexander Y., Roszik, Jason, Cote, Gilbert J., Subbiah, Vivek
Publicado 2021

Itraconazole Exerts Its Antitumor Effect in Esophageal Cancer By Suppressing the HER2/AKT Signaling Pathway

por Zhang, Wei, Bhagwath, Ankur S., Ramzan, Zeeshan, Williams, Taylor A., Subramaniyan, Indhumathy, Edpuganti, Vindhya, Kallem, Raja Reddy, Dunbar, Kerry B., Ding, Peiguo, Gong, Ke, Geurkink, Samuel A., Beg, Muhammad S., Kim, James, Zhang, Qiuyang, Habib, Amyn A., Choi, Sung-Hee, Lapsiwala, Ritu, Bhagwath, Gayathri, Dowell, Jonathan E., Melton, Shelby D., Jie, Chunfa, Putnam, William C., Pham, Thai H., Wang, David H.
Publicado 2021

T Cell–Mediated Antitumor Immunity Cooperatively Induced By TGFβR1 Antagonism and Gemcitabine Counteracts Reformation of the Stromal Barrier in Pancreatic Cancer

por Li, Dandan, Schaub, Nicholas, Guerin, Theresa M., Bapiro, Tashinga E., Richards, Frances M., Chen, Vicky, Talsania, Keyur, Kumar, Parimal, Gilbert, Debra J., Schlomer, Jerome J., Kim, Seong-Jin, Sorber, Rebecca, Teper, Yaroslav, Bautista, Wendy, Palena, Claudia, Ock, Chan-Young, Jodrell, Duncan I., Pate, Nathan, Mehta, Monika, Zhao, Yongmei, Kozlov, Serguei, Rudloff, Udo
Publicado 2021

Parallel Genomic Alterations of Antigen and Payload Targets Mediate Polyclonal Acquired Clinical Resistance to Sacituzumab Govitecan in Triple-Negative Breast Cancer

por Coates, James T., Sun, Sheng, Leshchiner, Ignaty, Thimmiah, Nayana, Martin, Elizabeth E., McLoughlin, Daniel, Danysh, Brian P., Slowik, Kara, Jacobs, Raquel A., Rhrissorrakrai, Kahn, Utro, Filippo, Levovitz, Chaya, Denault, Elyssa, Walmsley, Charlotte S., Kambadakone, Avinash, Stone, James R., Isakoff, Steven J., Parida, Laxmi, Juric, Dejan, Getz, Gad, Bardia, Aditya, Ellisen, Leif W.
Publicado 2021

Single-Cell Analysis of the Multicellular Ecosystem in Viral Carcinogenesis by HTLV-1

por Koya, Junji, Saito, Yuki, Kameda, Takuro, Kogure, Yasunori, Yuasa, Mitsuhiro, Nagasaki, Joji, McClure, Marni B., Shingaki, Sumito, Tabata, Mariko, Tahira, Yuki, Akizuki, Keiichi, Kamiunten, Ayako, Sekine, Masaaki, Shide, Kotaro, Kubuki, Yoko, Hidaka, Tomonori, Kitanaka, Akira, Nakano, Nobuaki, Utsunomiya, Atae, Togashi, Yosuke, Ogawa, Seishi, Shimoda, Kazuya, Kataoka, Keisuke
Publicado 2021

Niraparib for Advanced Breast Cancer with Germline BRCA1 and BRCA2 Mutations: the EORTC 1307-BCG/BIG5–13/TESARO PR-30–50–10-C BRAVO Study

por Turner, Nicholas C., Balmaña, Judith, Poncet, Coralie, Goulioti, Theodora, Tryfonidis, Konstantinos, Honkoop, Aafke H., Zoppoli, Gabriele, Razis, Evangelia, Johannsson, Oskar T., Colleoni, Marco, Tutt, Andrew N., Audeh, William, Ignatiadis, Michail, Mailliez, Audrey, Trédan, Olivier, Musolino, Antonino, Vuylsteke, Peter, Juan-Fita, Maria Jose, Macpherson, Iain R.J., Kaufman, Bella, Manso, Luis, Goldstein, Lori J., Ellard, Susan L., Láng, István, Jen, Kai Yu, Adam, Virginie, Litière, Saskia, Erban, John, Cameron, David A.
Publicado 2021

Oncogenic HSP90 Facilitates Metabolic Alterations in Aggressive B-cell Lymphomas

por Calvo-Vidal, M. Nieves, Zamponi, Nahuel, Krumsiek, Jan, Stockslager, Max A., Revuelta, Maria V., Phillip, Jude M., Marullo, Rossella, Tikhonova, Ekaterina, Kotlov, Nikita, Patel, Jayeshkumar, Yang, Shao Ning, Yang, Lucy, Taldone, Tony, Thieblemont, Catherine, Leonard, John P., Martin, Peter, Inghirami, Giorgio, Chiosis, Gabriela, Manalis, Scott R., Cerchietti, Leandro
Publicado 2021

A Phase I Study of the Combination of Pexidartinib and Sirolimus to Target Tumor-Associated Macrophages in Unresectable Sarcoma and Malignant Peripheral Nerve Sheath Tumors

por Manji, Gulam A., Van Tine, Brian A., Lee, Shing M., Raufi, Alexander G., Pellicciotta, Ilenia, Hirbe, Angela C., Pradhan, Jaya, Chen, Andrew, Rabadan, Raul, Schwartz, Gary K.
Publicado 2021

Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance

por Liu, Jianglan, Rebecca, Vito W., Kossenkov, Andrew V., Connelly, Thomas, Liu, Qin, Gutierrez, Alexis, Xiao, Min, Li, Ling, Zhang, Gao, Samarkina, Anastasia, Zayasbazan, Delaine, Zhang, Jie, Cheng, Chaoran, Wei, Zhi, Alicea, Gretchen M., Fukunaga-Kalabis, Mizuho, Krepler, Clemens, Aza-Blanc, Pedro, Yang, Chih-Cheng, Delvadia, Bela, Tong, Cynthia, Huang, Ye, Delvadia, Maya, Morias, Alice S., Sproesser, Katrin, Brafford, Patricia, Wang, Joshua X., Beqiri, Marilda, Somasundaram, Rajasekharan, Vultur, Adina, Hristova, Denitsa M., Wu, Lawrence W., Lu, Yiling, Mills, Gordon B., Xu, Wei, Karakousis, Giorgos C., Xu, Xiaowei, Schuchter, Lynn M., Mitchell, Tara C., Amaravadi, Ravi K., Kwong, Lawrence N., Frederick, Dennie T., Boland, Genevieve M., Salvino, Joseph M., Speicher, David W., Flaherty, Keith T., Ronai, Ze'ev A., Herlyn, Meenhard
Publicado 2021

Targeting HER2 Exon 20 Insertion–Mutant Lung Adenocarcinoma with a Novel Tyrosine Kinase Inhibitor Mobocertinib

por Han, Han, Li, Shuai, Chen, Ting, Fitzgerald, Michael, Liu, Shengwu, Peng, Chengwei, Tang, Kwan Ho, Cao, Shougen, Chouitar, Johara, Wu, Jiansheng, Peng, David, Deng, Jiehui, Gao, Zhendong, Baker, Theresa E., Li, Fei, Zhang, Hua, Pan, Yuanwang, Ding, Hailin, Hu, Hai, Pyon, Val, Thakurdin, Cassandra, Papadopoulos, Eleni, Tang, Sittinon, Gonzalvez, Francois, Chen, Haiquan, Rivera, Victor M., Brake, Rachael, Vincent, Sylvie, Wong, Kwok-Kin
Publicado 2021