The Mutational Signature Comprehensive Analysis Toolkit (musicatk) for the Discovery, Prediction, and Exploration of Mutational Signatures

por Chevalier, Aaron, Yang, Shiyi, Khurshid, Zainab, Sahelijo, Nathan, Tong, Tong, Huggins, Jonathan H., Yajima, Masanao, Campbell, Joshua D.
Publicado 2021

Monitoring PD-1 Phosphorylation to Evaluate PD-1 Signaling during Antitumor Immune Responses

por Bu, Xia, Juneja, Vikram R., Reynolds, Carol G., Mahoney, Kathleen M., Bu, Melissa T., McGuire, Kathleen A., Maleri, Seth, Hua, Ping, Zhu, Baogong, Klein, Sarah R., Greenfield, Edward A., Armand, Philippe, Ritz, Jerome, Sharpe, Arlene H., Freeman, Gordon J.
Publicado 2021

Adenosine A2A Receptor Activation Enhances Blood–Tumor Barrier Permeability in a Rodent Glioma Model

por Vézina, Amélie, Manglani, Monica, Morris, DreeAnna, Foster, Brandon, McCord, Matthew, Song, Hua, Zhang, Meili, Davis, Dionne, Zhang, Wei, Bills, Jessica, Nagashima, Kunio, Shankarappa, Priya, Kindrick, Jessica, Walbridge, Stuart, Peer, Cody J., Figg, William D., Gilbert, Mark R., McGavern, Dorian B., Muldoon, Leslie L., Jackson, Sadhana
Publicado 2021

lncRNA BORG:TRIM28 Complexes Drive Metastatic Progression by Inducing α6 Integrin/CD49f Expression in Breast Cancer Stem Cells

por Parker, Kimberly A., Gooding, Alex J., Valadkhan, Saba, Schiemann, William P.
Publicado 2021

Exposure Definition in Case–Control Studies of Cervical Cancer Screening: A Systematic Literature Review

por Castanon, Alejandra, Kamineni, Aruna, Elfström, K. Miriam, Lim, Anita W.W., Sasieni, Peter
Publicado 2021

Generalizability and Transportability of the National Lung Screening Trial Data: Extending Trial Results to Different Populations

por Inoue, Kosuke, Hsu, William, Arah, Onyebuchi A., Prosper, Ashley E., Aberle, Denise R., Bui, Alex A.T.
Publicado 2021

Disease-Associated Risk Variants in ANRIL Are Associated with Tumor-Infiltrating Lymphocyte Presence in Primary Melanomas in the Population-Based GEM Study

por Davari, Danielle R., Orlow, Irene, Kanetsky, Peter A., Luo, Li, Edmiston, Sharon N., Conway, Kathleen, Parrish, Eloise A., Hao, Honglin, Busam, Klaus J., Sharma, Ajay, Kricker, Anne, Cust, Anne E., Anton-Culver, Hoda, Gruber, Stephen B., Gallagher, Richard P., Zanetti, Roberto, Rosso, Stefano, Sacchetto, Lidia, Dwyer, Terence, Ollila, David W., Begg, Colin B., Berwick, Marianne, Thomas, Nancy E.
Publicado 2021

Radiopotentiation Profiling of Multiple Inhibitors of the DNA Damage Response for Early Clinical Development

por Gill, Sonja J., Wijnhoven, Paul W.G., Fok, Jacqueline H.L., Lloyd, Rebecca L., Cairns, Jonathan, Armenia, Joshua, Nikkilä, Jenni, Lau, Alan, Bakkenist, Christopher J., Galbraith, Susan M., Vens, Conchita, O'Connor, Mark J.
Publicado 2021

Antibody–Drug Conjugate Efficacy in Neuroblastoma: Role of Payload, Resistance Mechanisms, Target Density, and Antibody Internalization

por Buongervino, Samantha, Lane, Maria V., Garrigan, Emily, Zhelev, Doncho V., Dimitrov, Dimiter S., Bosse, Kristopher R.
Publicado 2021

Neoadjuvant Selicrelumab, an Agonist CD40 Antibody, Induces Changes in the Tumor Microenvironment in Patients with Resectable Pancreatic Cancer

por Byrne, Katelyn T., Betts, Courtney B., Mick, Rosemarie, Sivagnanam, Shamilene, Bajor, David L., Laheru, Daniel A., Chiorean, E. Gabriela, O'Hara, Mark H., Liudahl, Shannon M., Newcomb, Craig, Alanio, Cécile, Ferreira, Ana P., Park, Byung S., Ohtani, Takuya, Huffman, Austin P., Väyrynen, Sara A., Dias Costa, Andressa, Kaiser, Judith C., Lacroix, Andreanne M., Redlinger, Colleen, Stern, Martin, Nowak, Jonathan A., Wherry, E. John, Cheever, Martin A., Wolpin, Brian M., Furth, Emma E., Jaffee, Elizabeth M., Coussens, Lisa M., Vonderheide, Robert H.
Publicado 2021

Clinical Trials Assessing Hypomethylating Agents Combined with Other Therapies: Causes for Failure and Potential Solutions

por Zavras, Phaedon D., Shastri, Aditi, Goldfinger, Mendel, Verma, Amit K., Saunthararajah, Yogen
Publicado 2021

Neoadjuvant FOLFIRINOX Therapy Is Associated with Increased Effector T Cells and Reduced Suppressor Cells in Patients with Pancreatic Cancer

por Peng, Hui, James, C. Alston, Cullinan, Darren R., Hogg, Graham D., Mudd, Jacqueline L., Zuo, Chong, Takchi, Rony, Caldwell, Katharine E., Liu, Jingxia, DeNardo, David G., Fields, Ryan C., Gillanders, William E., Goedegebuure, S. Peter, Hawkins, William G.
Publicado 2021

Gilteritinib Inhibits Glutamine Uptake and Utilization in FLT3-ITD–Positive AML

por Zavorka Thomas, Megan E., Lu, Xiyuan, Talebi, Zahra, Jeon, Jae Yoon, Buelow, Daelynn R., Gibson, Alice A., Uddin, Muhammad Erfan, Brinton, Lindsey T., Nguyen, Julie, Collins, Meghan, Lodi, Alessia, Sweeney, Shannon R., Campbell, Moray J., Sweet, Douglas H., Sparreboom, Alex, Lapalombella, Rosa, Tiziani, Stefano, Baker, Sharyn D.
Publicado 2021

Intentional Modulation of Ibrutinib Pharmacokinetics through CYP3A Inhibition

por Eisenmann, Eric D., Fu, Qiang, Muhowski, Elizabeth M., Jin, Yan, Uddin, Muhammad Erfan, Garrison, Dominique A., Weber, Robert H., Woyach, Jennifer A., Byrd, John C., Sparreboom, Alex, Baker, Sharyn D.
Publicado 2021

Sex- and Mutation-Specific p53 Gain-of-Function Activity in Gliomagenesis

por Rockwell, Nathan C., Yang, Wei, Warrington, Nicole M., Staller, Max V., Griffith, Malachi, Griffith, Obi L., Gurnett, Christina A., Cohen, Barak A., Baldridge, Dustin, Rubin, Joshua B.
Publicado 2021

Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma

por Puca, Francesca, Yu, Fei, Bartolacci, Caterina, Pettazzoni, Piergiorgio, Carugo, Alessandro, Huang-Hobbs, Emmet, Liu, Jintan, Zanca, Ciro, Carbone, Federica, Del Poggetto, Edoardo, Gumin, Joy, Dasgupta, Pushan, Seth, Sahil, Srinivasan, Sanjana, Lang, Frederick F., Sulman, Erik P., Lorenzi, Philip L., Tan, Lin, Shan, Mengrou, Tolstyka, Zachary P., Kachman, Maureen, Zhang, Li, Gao, Sisi, Deem, Angela K., Genovese, Giannicola, Scaglioni, Pier Paolo, Lyssiotis, Costas A., Viale, Andrea, Draetta, Giulio F.
Publicado 2021

FLASH Proton Radiotherapy Spares Normal Epithelial and Mesenchymal Tissues While Preserving Sarcoma Response

por Velalopoulou, Anastasia, Karagounis, Ilias V., Cramer, Gwendolyn M., Kim, Michele M., Skoufos, Giorgos, Goia, Denisa, Hagan, Sarah, Verginadis, Ioannis I., Shoniyozov, Khayrullo, Chiango, June, Cerullo, Michelle, Varner, Kelley, Yao, Lutian, Qin, Ling, Hatzigeorgiou, Artemis G., Minn, Andy J., Putt, Mary, Lanza, Matthew, Assenmacher, Charles-Antoine, Radaelli, Enrico, Huck, Jennifer, Diffenderfer, Eric, Dong, Lei, Metz, James, Koumenis, Constantinos, Cengel, Keith A., Maity, Amit, Busch, Theresa M.
Publicado 2021

Protein Phosphatase 2A as a Therapeutic Target in Small Cell Lung Cancer

por Mirzapoiazova, Tamara, Xiao, Gang, Mambetsariev, Bolot, Nasser, Mohd W., Miaou, Emily, Singhal, Sharad S., Srivastava, Saumya, Mambetsariev, Isa, Nelson, Michael S., Nam, Arin, Behal, Amita, Atri, Pranita, Muschen, Markus, Tissot, François L.H., Miser, James, Kovach, John S., Sattler, Martin, Batra, Surinder K., Kulkarni, Prakash, Salgia, Ravi
Publicado 2021

Neoadjuvant STING Activation, Extended Half-life IL2, and Checkpoint Blockade Promote Metastasis Clearance via Sustained NK-cell Activation

por Milling, Lauren E., Garafola, Daniel, Agarwal, Yash, Wu, Shengwei, Thomas, Ayush, Donahue, Nathan, Adams, Josetta, Thai, Nikki, Suh, Heikyung, Irvine, Darrell J.
Publicado 2022

Gene-Level Germline Contributions to Clinical Risk of Recurrence Scores in Black and White Patients with Breast Cancer

por Patel, Achal, García-Closas, Montserrat, Olshan, Andrew F., Perou, Charles M., Troester, Melissa A., Love, Michael I., Bhattacharya, Arjun
Publicado 2022