Clinical Trials with Biologic Primary Endpoints in Immuno-oncology: Concepts and Usage

por Isaacs, James, Tan, Aaron C., Hanks, Brent A., Wang, Xiaofei, Owzar, Kouros, Herndon, James E., Antonia, Scott J., Piantadosi, Steven, Khasraw, Mustafa
Publicado 2022

Regulation of Chemosensitivity in Human Medulloblastoma Cells by p53 and the PI3 Kinase Signaling Pathway

por Naeem, Aisha, Harish, Varsha, Coste, Sophie, Parasido, Erika M., Choudhry, Muhammad Umer, Kromer, Lawrence F., Ihemelandu, Chukuemeka, Petricoin, Emanuel F., Pierobon, Mariaelena, Noon, Muhammad Saad, Yenugonda, Venkata Mahidhar, Avantaggiati, Maria, Kupfer, Gary M., Fricke, Stanley, Rodriguez, Olga, Albanese, Chris
Publicado 2022

The Prognostic Role of MYC Structural Variants Identified by NGS and FISH in Multiple Myeloma

por Sharma, Neeraj, Smadbeck, James B., Abdallah, Nadine, Zepeda-Mendoza, Cinthya, Binder, Moritz, Pearce, Kathryn E., Asmann, Yan W., Peterson, Jess F., Ketterling, Rhett P., Greipp, Patricia T., Bergsagel, P. Leif, Rajkumar, S. Vincent, Kumar, Shaji K., Baughn, Linda B.
Publicado 2021

A FZD7-specific Antibody–Drug Conjugate Induces Ovarian Tumor Regression in Preclinical Models

por Do, Myan, Wu, Christina C.N., Sonavane, Pooja R., Juarez, Edwin F., Adams, Stephen R., Ross, Jason, Rodriguez y Baena, Alessandra, Patel, Charmi, Mesirov, Jill P., Carson, Dennis A., Advani, Sunil J., Willert, Karl
Publicado 2022

Overcoming Gemcitabine Resistance in Pancreatic Cancer Using the BCL-X(L)–Specific Degrader DT2216

por Thummuri, Dinesh, Khan, Sajid, Underwood, Patrick W., Zhang, Peiyi, Wiegand, Janet, Zhang, Xuan, Budamagunta, Vivekananda, Sobh, Amin, Tagmount, Abderrahmane, Loguinov, Alexander, Riner, Andrea N., Akki, Ashwin S., Williamson, Elizabeth, Hromas, Robert, Vulpe, Christopher D., Zheng, Guangrong, Trevino, Jose G., Zhou, Daohong
Publicado 2022

HSP90-Specific nIR Probe Identifies Aggressive Prostate Cancers: Translation from Preclinical Models to a Human Phase I Study

por Osada, Takuya, Crosby, Erika J., Kaneko, Kensuke, Snyder, Joshua C., Ginzel, Joshua D., Acharya, Chaitanya R., Yang, Xiao-Yi, Polascik, Thomas J., Spasojevic, Ivan, Nelson, Rendon C., Hobeika, Amy, Hartman, Zachary C., Neckers, Leonard M., Rogatko, Andre, Hughes, Philip F., Huang, Jiaoti, Morse, Michael A., Haystead, Timothy, Lyerly, H. Kim
Publicado 2022

Triple Targeting of Breast Tumors Driven by Hormonal Receptors and HER2

por Shagisultanova, Elena, Crump, Lyndsey S., Borakove, Michelle, Hall, Jessica K., Rasti, Aryana R., Harrison, Benjamin A., Kabos, Peter, Lyons, Traci R., Borges, Virginia F.
Publicado 2022

Linking Physical Activity to Breast Cancer: Text Mining Results and a Protocol for Systematically Reviewing Three Potential Mechanistic Pathways

por Lynch, Brigid M., Milne, Roger L., English, Dallas R., Brown, Kristy A., Drummond, Ann E., Swain, Christopher T.V., van Roekel, Eline H., Moore, Melissa M., Gaunt, Tom R., Martin, Richard M., Lewis, Sarah J.
Publicado 2022

Gut Microbiome–Dependent Metabolic Pathways and Risk of Lethal Prostate Cancer: Prospective Analysis of a PLCO Cancer Screening Trial Cohort

por Reichard, Chad A., Naelitz, Bryan D., Wang, Zeneng, Jia, Xun, Li, Jianbo, Stampfer, Meir J., Klein, Eric A., Hazen, Stanley L., Sharifi, Nima
Publicado 2022

TP53 Pathway Function, Estrogen Receptor Status, and Breast Cancer Risk Factors in the Carolina Breast Cancer Study

por Hurson, Amber N., Abubakar, Mustapha, Hamilton, Alina M., Conway, Kathleen, Hoadley, Katherine A., Love, Michael I., Olshan, Andrew F., Perou, Charles M., Garcia-Closas, Montserrat, Troester, Melissa A.
Publicado 2022

Upregulation of C/EBPα Inhibits Suppressive Activity of Myeloid Cells and Potentiates Antitumor Response in Mice and Patients with Cancer

por Hashimoto, Ayumi, Sarker, Debashis, Reebye, Vikash, Jarvis, Sheba, Sodergren, Mikael H., Kossenkov, Andrew, Sanseviero, Emilio, Raulf, Nina, Vasara, Jenni, Andrikakou, Pinelopi, Meyer, Tim, Huang, Kai-Wen, Plummer, Ruth, Chee, Cheng E., Spalding, Duncan, Pai, Madhava, Khan, Shahid, Pinato, David J., Sharma, Rohini, Basu, Bristi, Palmer, Daniel, Ma, Yuk-Ting, Evans, Jeff, Habib, Robert, Martirosyan, Anna, Elasri, Naouel, Reynaud, Adeline, Rossi, John J., Cobbold, Mark, Habib, Nagy A., Gabrilovich, Dmitry I.
Publicado 2021

Combined Inhibition of SHP2 and CXCR1/2 Promotes Antitumor T-cell Response in NSCLC

por Tang, Kwan Ho, Li, Shuai, Khodadadi-Jamayran, Alireza, Jen, Jayu, Han, Han, Guidry, Kayla, Chen, Ting, Hao, Yuan, Fedele, Carmine, Zebala, John A., Maeda, Dean Y., Christensen, James G., Olson, Peter, Athanas, Argus, Loomis, Cynthia A., Tsirigos, Aristotelis, Wong, Kwok-Kin, Neel, Benjamin G.
Publicado 2022

Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor

por Huang, Yung-Hsin, Chen, Chun-Wei, Sundaramurthy, Venkatasubramaniam, Słabicki, Mikołaj, Hao, Dapeng, Watson, Caroline J., Tovy, Ayala, Reyes, Jaime M., Dakhova, Olga, Crovetti, Brielle R., Galonska, Christina, Lee, Minjung, Brunetti, Lorenzo, Zhou, Yubin, Tatton-Brown, Katrina, Huang, Yun, Cheng, Xiaodong, Meissner, Alexander, Valk, Peter J.M., Van Maldergem, Lionel, Sanders, Mathijs A., Blundell, Jamie R., Li, Wei, Ebert, Benjamin L., Goodell, Margaret A.
Publicado 2022

Rates and Patterns of Clonal Oncogenic Mutations in the Normal Human Brain

por Ganz, Javier, Maury, Eduardo A., Becerra, Basheer, Bizzotto, Sara, Doan, Ryan N., Kenny, Connor J., Shin, Taehwan, Kim, Junho, Zhou, Zinan, Ligon, Keith L., Lee, Eunjung Alice, Walsh, Christopher A.
Publicado 2022

Prediction of Pancreatic Cancer in Diabetes Patients with Worsening Glycemic Control

por Jeon, Christie Y., Kim, Sungjin, Lin, Yu-Chen, Risch, Harvey A., Goodarzi, Mark O., Nuckols, Teryl K., Freedland, Stephen J., Pandol, Stephen J., Pisegna, Joseph R.
Publicado 2022

Repurposing Ceritinib Induces DNA Damage and Enhances PARP Inhibitor Responses in High-Grade Serous Ovarian Carcinoma

por Kanakkanthara, Arun, Hou, Xiaonan, Ekstrom, Thomas L., Zanfagnin, Valentina, Huehls, Amelia M., Kelly, Rebecca L., Ding, Husheng, Larson, Melissa C., Vasmatzis, George, Oberg, Ann L., Kaufmann, Scott H., Mansfield, Aaron S., Weroha, S. John, Karnitz, Larry M.
Publicado 2022

Clinical Activity of Single-Agent Cabozantinib (XL184), a Multi-receptor Tyrosine Kinase Inhibitor, in Patients with Refractory Soft-Tissue Sarcomas

por O'Sullivan Coyne, Geraldine, Kummar, Shivaani, Hu, James, Ganjoo, Kristen, Chow, Warren A., Do, Khanh T., Zlott, Jennifer, Bruns, Ashley, Rubinstein, Lawrence, Foster, Jared C., Juwara, Lamin, Meehan, Robert, Piekarz, Richard, Streicher, Howard, Sharon, Elad, Takebe, Naoko, Voth, Andrea Regier, Bottaro, Donald, Costello, Rene, Wright, John J., Doroshow, James H., Chen, Alice P.
Publicado 2022

(18)F-FMISO PET Imaging Identifies Hypoxia and Immunosuppressive Tumor Microenvironments and Guides Targeted Evofosfamide Therapy in Tumors Refractory to PD-1 and CTLA-4 Inhibition

por Reeves, Kirsten M., Song, Patrick N., Angermeier, Allyson, Manna, Deborah Della, Li, Yufeng, Wang, Jianbo, Yang, Eddy S., Sorace, Anna G., Larimer, Benjamin M.
Publicado 2022

Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing

por Newman, Scott, Nakitandwe, Joy, Kesserwan, Chimene A., Azzato, Elizabeth M., Wheeler, David A., Rusch, Michael, Shurtleff, Sheila, Hedges, Dale J., Hamilton, Kayla V., Foy, Scott G., Edmonson, Michael N., Thrasher, Andrew, Bahrami, Armita, Orr, Brent A., Klco, Jeffery M., Gu, Jiali, Harrison, Lynn W., Wang, Lu, Clay, Michael R., Ouma, Annastasia, Silkov, Antonina, Liu, Yanling, Zhang, Zhaojie, Liu, Yu, Brady, Samuel W., Zhou, Xin, Chang, Ti-Cheng, Pande, Manjusha, Davis, Eric, Becksfort, Jared, Patel, Aman, Wilkinson, Mark R., Rahbarinia, Delaram, Kubal, Manish, Maciaszek, Jamie L., Pastor, Victor, Knight, Jay, Gout, Alexander M., Wang, Jian, Gu, Zhaohui, Mullighan, Charles G., McGee, Rose B., Quinn, Emily A., Nuccio, Regina, Mostafavi, Roya, Gerhardt, Elsie L., Taylor, Leslie M., Valdez, Jessica M., Hines-Dowell, Stacy J., Pappo, Alberto S., Robinson, Giles, Johnson, Liza-Marie, Pui, Ching-Hon, Ellison, David W., Downing, James R., Zhang, Jinghui, Nichols, Kim E.
Publicado 2021

Tumor-Specific Major Histocompatibility-II Expression Predicts Benefit to Anti–PD-1/L1 Therapy in Patients With HER2-Negative Primary Breast Cancer

por Gonzalez-Ericsson, Paula I., Wulfkhule, Julia D., Gallagher, Rosa I., Sun, Xiaopeng, Axelrod, Margaret L., Sheng, Quanhu, Luo, Na, Gomez, Henry, Sanchez, Violeta, Sanders, Melinda, Pusztai, Lajos, Petricoin, Emanuel, Blenman, Kim R.M., Balko, Justin M.
Publicado 2021