Overcoming PD-1 Blockade Resistance with CpG-A Toll-Like Receptor 9 Agonist Vidutolimod in Patients with Metastatic Melanoma

por Ribas, Antoni, Medina, Theresa, Kirkwood, John M., Zakharia, Yousef, Gonzalez, Rene, Davar, Diwakar, Chmielowski, Bartosz, Campbell, Katie M., Bao, Riyue, Kelley, Heather, Morris, Aaron, Mauro, David, Wooldridge, James E., Luke, Jason J., Weiner, George J., Krieg, Arthur M., Milhem, Mohammed M.
Publicado 2021

Blocking Short-Form Ron Eliminates Breast Cancer Metastases through Accumulation of Stem-Like CD4(+) T Cells That Subvert Immunosuppression

por Lai, Shu-Chin Alicia, Gundlapalli, Harika, Ekiz, H. Atakan, Jiang, Amanda, Fernandez, Elvelyn, Welm, Alana L.
Publicado 2021

Prostate Cancer Risk Stratification via Nondestructive 3D Pathology with Deep Learning–Assisted Gland Analysis

por Xie, Weisi, Reder, Nicholas P., Koyuncu, Can, Leo, Patrick, Hawley, Sarah, Huang, Hongyi, Mao, Chenyi, Postupna, Nadia, Kang, Soyoung, Serafin, Robert, Gao, Gan, Han, Qinghua, Bishop, Kevin W., Barner, Lindsey A., Fu, Pingfu, Wright, Jonathan L., Keene, C. Dirk, Vaughan, Joshua C., Janowczyk, Andrew, Glaser, Adam K., Madabhushi, Anant, True, Lawrence D., Liu, Jonathan T.C.
Publicado 2022

Characteristics and Spatially Defined Immune (micro)landscapes of Early-stage PD-L1–positive Triple-negative Breast Cancer

por Carter, Jodi M., Polley, Mei-Yin C., Leon-Ferre, Roberto A., Sinnwell, Jason, Thompson, Kevin J., Wang, Xue, Ma, Yaohua, Zahrieh, David, Kachergus, Jennifer M., Solanki, Malvika, Boughey, Judy C., Liu, Minetta C., Ingle, James N., Kalari, Krishna R., Couch, Fergus J., Thompson, E. Aubrey, Goetz, Matthew P.
Publicado 2021

A Phase II Study of the Efficacy and Safety of Oral Selinexor in Recurrent Glioblastoma

por Lassman, Andrew B., Wen, Patrick Y., van den Bent, Martin J., Plotkin, Scott R., Walenkamp, Annemiek M.E., Green, Adam L., Li, Kai, Walker, Christopher J., Chang, Hua, Tamir, Sharon, Henegar, Leah, Shen, Yao, Alvarez, Mariano J., Califano, Andrea, Landesman, Yosef, Kauffman, Michael G., Shacham, Sharon, Mau-Sørensen, Morten
Publicado 2022

Clonal Hematopoiesis Mutations in Patients with Lung Cancer Are Associated with Lung Cancer Risk Factors

por Hong, Wei, Li, Ang, Liu, Yanhong, Xiao, Xiangjun, Christiani, David C., Hung, Rayjean J., McKay, James, Field, John, Amos, Christopher I., Cheng, Chao
Publicado 2022

PERK, Beyond an Unfolded Protein Response Sensor in Estrogen-Induced Apoptosis in Endocrine-Resistant Breast Cancer

por Fan, Ping, Jordan, V. Craig
Publicado 2022

NKG7 Is a T-cell–Intrinsic Therapeutic Target for Improving Antitumor Cytotoxicity and Cancer Immunotherapy

por Wen, Ti, Barham, Whitney, Li, Ying, Zhang, Henan, Gicobi, Joanina K., Hirdler, Jacob B., Liu, Xin, Ham, Hyoungjun, Peterson Martinez, Kodi E., Lucien, Fabrice, Lavoie, Roxane R., Li, Hu, Correia, Cristina, Monie, Dileep D., An, Zesheng, Harrington, Susan M., Wu, Xiaosheng, Guo, Ruifeng, Dronca, Roxana S., Mansfield, Aaron S., Yan, Yiyi, Markovic, Svetomir N., Park, Sean S., Sun, Jie, Qin, Hong, Liu, Minetta C., Vasmatzis, George, Billadeau, Daniel D., Dong, Haidong
Publicado 2022

TOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas

por Gonzalez-Buendia, Edgar, Zhao, Junfei, Wang, Lu, Mukherjee, Subhas, Zhang, Daniel, Arrieta, Víctor A., Feldstein, Eric, Kane, J. Robert, Kang, Seong Jae, Lee-Chang, Catalina, Mahajan, Aayushi, Chen, Li, Realubit, Ronald, Karan, Charles, Magnuson, Lisa, Horbinski, Craig, Marshall, Stacy A., Sarkaria, Jann N., Mohyeldin, Ahmed, Nakano, Ichiro, Bansal, Mukesh, James, Charles D., Brat, Daniel J., Ahmed, Atique, Canoll, Peter, Rabadan, Raul, Shilatifard, Ali, Sonabend, Adam M.
Publicado 2021

Contributions of Social Factors to Disparities in Prostate Cancer Risk Profiles among Black Men and Non-Hispanic White Men with Prostate Cancer in California

por Press, David J., Shariff-Marco, Salma, Lichtensztajn, Daphne Y., Lauderdale, Diane, Murphy, Adam B., Inamdar, Pushkar P., DeRouen, Mindy C., Hamilton, Ann S., Yang, Juan, Lin, Katherine, Hedeker, Donald, Haiman, Christopher A., Cheng, Iona, Gomez, Scarlett Lin
Publicado 2022

Air Pollution and Breast Cancer: An Examination of Modification By Underlying Familial Breast Cancer Risk

por Niehoff, Nicole M., Terry, Mary Beth, Bookwalter, Deborah B., Kaufman, Joel D., O'Brien, Katie M., Sandler, Dale P., White, Alexandra J.
Publicado 2022

Tumor Suppressor PLK2 May Serve as a Biomarker in Triple-Negative Breast Cancer for Improved Response to PLK1 Therapeutics

por Gao, Yang, Kabotyanski, Elena B., Shepherd, Jonathan H., Villegas, Elizabeth, Acosta, Deanna, Hamor, Clark, Sun, Tingting, Montmeyor-Garcia, Celina, He, Xiaping, Dobrolecki, Lacey E., Westbrook, Thomas F., Lewis, Michael T., Hilsenbeck, Susan G., Zhang, Xiang H.-F., Perou, Charles M., Rosen, Jeffrey M.
Publicado 2021

Cyclin-dependent Kinase 4/6 Inhibitor Palbociclib in Combination with Ralaniten Analogs for the Treatment of Androgen Receptor–positive Prostate and Breast Cancers

por Tien, Amy H., Sadar, Marianne D.
Publicado 2022

INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors

por Li, Qing, Jiang, Baishan, Guo, Jiaye, Shao, Hong, Del Priore, Isabella S., Chang, Qing, Kudo, Rei, Li, Zhiqiang, Razavi, Pedram, Liu, Bo, Boghossian, Andrew S., Rees, Matthew G., Ronan, Melissa M., Roth, Jennifer A., Donovan, Katherine A., Palafox, Marta, Reis-Filho, Jorge S., de Stanchina, Elisa, Fischer, Eric S., Rosen, Neal, Serra, Violeta, Koff, Andrew, Chodera, John D., Gray, Nathanael S., Chandarlapaty, Sarat
Publicado 2022

SLC5A3-Dependent Myo-inositol Auxotrophy in Acute Myeloid Leukemia

por Wei, Yiliang, Huang, Yu-Han, Skopelitis, Damianos S., Iyer, Shruti V., Costa, Ana S.H., Yang, Zhaolin, Kramer, Melissa, Adelman, Emmalee R., Klingbeil, Olaf, Demerdash, Osama E., Polyanskaya, Sofya A., Chang, Kenneth, Goodwin, Sara, Hodges, Emily, McCombie, W. Richard, Figueroa, Maria E., Vakoc, Christopher R.
Publicado 2022

An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML

por Lin, Shan, Larrue, Clément, Scheidegger, Nastassja K., Seong, Bo Kyung A., Dharia, Neekesh V., Kuljanin, Miljan, Wechsler, Caroline S., Kugener, Guillaume, Robichaud, Amanda L., Conway, Amy Saur, Mashaka, Thelma, Mouche, Sarah, Adane, Biniam, Ryan, Jeremy A., Mancias, Joseph D., Younger, Scott T., Piccioni, Federica, Lee, Lynn H., Wunderlich, Mark, Letai, Anthony, Tamburini, Jérôme, Stegmaier, Kimberly
Publicado 2022

Mesenchymal Lineage Heterogeneity Underlies Nonredundant Functions of Pancreatic Cancer–Associated Fibroblasts

por Helms, Erin J., Berry, Mark W., Chaw, R. Crystal, DuFort, Christopher C., Sun, Duanchen, Onate, M. Kathrina, Oon, Chet, Bhattacharyya, Sohinee, Sanford-Crane, Hannah, Horton, Wesley, Finan, Jennifer M., Sattler, Ariana, Makar, Rosemary, Dawson, David W., Xia, Zheng, Hingorani, Sunil R., Sherman, Mara H.
Publicado 2022

Sex-Biased ZRSR2 Mutations in Myeloid Malignancies Impair Plasmacytoid Dendritic Cell Activation and Apoptosis

por Togami, Katsuhiro, Chung, Sun Sook, Madan, Vikas, Booth, Christopher A.G., Kenyon, Christopher M., Cabal-Hierro, Lucia, Taylor, Justin, Kim, Sunhee S., Griffin, Gabriel K., Ghandi, Mahmoud, Li, Jia, Li, Yvonne Y., Angelot-Delettre, Fanny, Biichle, Sabeha, Seiler, Michael, Buonamici, Silvia, Lovitch, Scott B., Louissaint, Abner, Morgan, Elizabeth A., Jardin, Fabrice, Piccaluga, Pier Paolo, Weinstock, David M., Hammerman, Peter S., Yang, Henry, Konopleva, Marina, Pemmaraju, Naveen, Garnache-Ottou, Francine, Abdel-Wahab, Omar, Koeffler, H. Phillip, Lane, Andrew A.
Publicado 2022

MYC Levels Regulate Metastatic Heterogeneity in Pancreatic Adenocarcinoma

por Maddipati, Ravikanth, Norgard, Robert J., Baslan, Timour, Rathi, Komal S., Zhang, Amy, Saeid, Asal, Higashihara, Taku, Wu, Feng, Kumar, Angad, Annamalai, Valli, Bhattacharya, Saurav, Raman, Pichai, Adkisson, Christian A., Pitarresi, Jason R., Wengyn, Maximilian D., Yamazoe, Taiji, Li, Jinyang, Balli, David, LaRiviere, Michael J., Ngo, Tuong-Vi C., Folkert, Ian W., Millstein, Ian D., Bermeo, Jonathan, Carpenter, Erica L., McAuliffe, John C., Oktay, Maja H., Brekken, Rolf A., Lowe, Scott W., Iacobuzio-Donahue, Christine A., Notta, Faiyaz, Stanger, Ben Z.
Publicado 2022

Immune Activity and Response Differences of Oncolytic Viral Therapy in Recurrent Glioblastoma: Gene Expression Analyses of a Phase IB Study

por Miller, Katherine E., Cassady, Kevin A., Roth, Justin C., Clements, Jennifer, Schieffer, Kathleen M., Leraas, Kristen, Miller, Anthony R., Prasad, Nripesh, Leavenworth, Jianmei W., Aban, Inmaculada B., Whitley, Richard J., Gillespie, G. Yancey, Mardis, Elaine R., Markert, James M.
Publicado 2022