HSP70 Inhibition Blocks Adaptive Resistance and Synergizes with MEK Inhibition for the Treatment of NRAS-Mutant Melanoma

por Parris, Joshua L.D., Barnoud, Thibaut, Leu, Julia I.-Ju, Leung, Jessica C., Ma, Weili, Kirven, Nicole A., Poli, Adi Naryana Reddy, Kossenkov, Andrew V., Liu, Qin, Salvino, Joseph M., George, Donna L., Weeraratna, Ashani T., Chen, Qing, Murphy, Maureen E.
Publicado 2021

Targeting the P53 Protein for Cancer Therapies: The Translational Impact of P53 Research

por Levine, Arnold J.
Publicado 2022

Novel Redirected T–Cell Immunotherapies for Advanced Prostate Cancer

por Dorff, Tanya B., Narayan, Vivek, Forman, Stephen J., Zang, Peter D., Fraietta, Joseph A., June, Carl H., Haas, Naomi B., Priceman, Saul J.
Publicado 2022

Adding Base-Excision Repair Inhibitor TRC102 to Standard Pemetrexed–Platinum–Radiation in Patients with Advanced Nonsquamous Non–Small Cell Lung Cancer: Results of a Phase I Trial...

por Biswas, Tithi, Dowlati, Afshin, Kunos, Charles A., Pink, John J., Oleinick, Nancy L., Malik, Shakun, Fu, Pingfu, Cao, Shufen, Bruno, Debora S., Bajor, David L., Patel, Monaliben, Gerson, Stanton L., Machtay, Mitchell
Publicado 2022

DNMT3A Harboring Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks

por Venugopal, Kartika, Feng, Yang, Nowialis, Pawel, Xu, Huanzhou, Shabashvili, Daniil E., Berntsen, Cassandra M., Kaur, Prabhjot, Krajcik, Kathryn I., Taragjini, Christina, Zaroogian, Zachary, Casellas Román, Heidi L., Posada, Luisa M., Gunaratne, Chamara, Li, Jianping, Dupéré-Richer, Daphné, Bennett, Richard L., Pondugula, Santhi, Riva, Alberto, Cogle, Christopher R., Opavsky, Rene, Law, Brian K., Bhaduri-McIntosh, Sumita, Kubicek, Stefan, Staber, Philipp B., Licht, Jonathan D., Bird, Jonathan E., Guryanova, Olga A.
Publicado 2022

Losartan Blocks Osteosarcoma-Elicited Monocyte Recruitment, and Combined With the Kinase Inhibitor Toceranib, Exerts Significant Clinical Benefit in Canine Metastatic Osteosarcoma

por Regan, Daniel P., Chow, Lyndah, Das, Sunetra, Haines, Laurel, Palmer, Eric, Kurihara, Jade N., Coy, Jonathan W., Mathias, Alissa, Thamm, Douglas H., Gustafson, Daniel L., Dow, Steven W.
Publicado 2022

The Liver–Immunity Nexus and Cancer Immunotherapy

por Lee, James C., Green, Michael D., Huppert, Laura A., Chow, Christine, Pierce, Robert H., Daud, Adil I.
Publicado 2022

Tadalafil Enhances Immune Signatures in Response to Neoadjuvant Nivolumab in Resectable Head and Neck Squamous Cell Carcinoma

por Luginbuhl, Adam J., Johnson, Jennifer M., Harshyne, Larry A., Linnenbach, Alban J., Shukla, Sanket K., Alnemri, Angela, Kumar, Gaurav, Cognetti, David M., Curry, Joseph M., Kotlov, Nikita, Antysheva, Zoya, Degryse, Sandrine, Mannion, Kyle, Gibson, Michael K., Netterville, James, Brown, Brandee, Axelrod, Rita, Zinner, Ralph, Tuluc, Madalina, Gargano, Stacey, Leiby, Benjamin E., Shimada, Ayako, Mahoney, My G., Martinez-Outschoorn, Ubaldo, Rodeck, Ulrich, Kim, Young J., South, Andrew P., Argiris, Athanassios
Publicado 2022

Long-term Follow-up and Patterns of Response, Progression, and Hyperprogression in Patients after PD-1 Blockade in Advanced Sarcoma

por Klemen, Nicholas D., Hwang, Sinchun, Bradic, Martina, Rosenbaum, Evan, Dickson, Mark A., Gounder, Mrinal M., Kelly, Ciara M., Keohan, Mary L., Movva, Sujana, Thornton, Katherine A., Chi, Ping, Nacev, Benjamin A., Chan, Jason E., Bartlett, Edmund K., Richards, Allison L., Singer, Samuel, Donoghue, Mark T.A., Tap, William D., D'Angelo, Sandra P.
Publicado 2022

Quantification of T- and B-cell Immune Receptor Distribution Diversity Characterizes Immune Cell Infiltration and Lymphocyte Heterogeneity in Clear Cell Renal Cell Carcinoma

por Ferrall-Fairbanks, Meghan C., Chakiryan, Nicholas H., Chobrutskiy, Boris I., Kim, Youngchul, Teer, Jamie K., Berglund, Anders, Mulé, James J., Fournier, Michelle, Siegel, Erin M., Dhillon, Jasreman, Falasiri, Seyed Shayan A., Arturo, Juan F., Katende, Esther N., Blanck, George, Manley, Brandon J., Altrock, Philipp M.
Publicado 2022

Tumor MHC Class I Expression Associates with Intralesional IL2 Response in Melanoma

por Pourmaleki, Maryam, Jones, Caitlin J., Ariyan, Charlotte E., Zeng, Zheng, Pirun, Mono, Navarrete, Daniel A., Li, Yanyun, Zhang, Mianlei, Nandakumar, Subhiksha, Campos, Carl, Nadeem, Saad, Klimstra, David S., Temple-Oberle, Claire F., Brenn, Thomas, Lipson, Evan J., Schenk, Kara M., Stein, Julie E., Taube, Janis M., White, Michael G., Traweek, Raymond, Wargo, Jennifer A., Kirkwood, John M., Gasmi, Billel, Goff, Stephanie L., Corwin, Alex D., McDonough, Elizabeth, Ginty, Fiona, Callahan, Margaret K., Schietinger, Andrea, Socci, Nicholas D., Mellinghoff, Ingo K., Hollmann, Travis J.
Publicado 2022

ImmunoPET of Ovarian and Pancreatic Cancer with AR9.6, a Novel MUC16-Targeted Therapeutic Antibody

por Sharma, Sai Kiran, Mack, Kyeara N., Piersigilli, Alessandra, Pourat, Jacob, Edwards, Kimberly J., Keinänen, Outi, Jiao, Maria S., Zhao, Huiyong, White, Brandy, Brooks, Cory L., de Stanchina, Elisa, Madiyalakan, Madi R., Hollingsworth, Michael A., Radhakrishnan, Prakash, Lewis, Jason S., Zeglis, Brian M.
Publicado 2022

PBRM1 Inactivation Promotes Upregulation of Human Endogenous Retroviruses in a HIF-Dependent Manner

por Zhou, Mi, Leung, Janet Y., Gessner, Kathryn H., Hepperla, Austin J., Simon, Jeremy M., Davis, Ian J., Kim, William Y.
Publicado 2022

Mechanical Stress Signaling in Pancreatic Cancer Cells Triggers p38 MAPK- and JNK-Dependent Cytoskeleton Remodeling and Promotes Cell Migration via Rac1/cdc42/Myosin II

por Kalli, Maria, Li, Ruxuan, Mills, Gordon B., Stylianopoulos, Triantafyllos, Zervantonakis, Ioannis K.
Publicado 2022

A Functional Precision Oncology Approach to Identify Treatment Strategies for Myxofibrosarcoma Patients

por Pauli, Chantal, De Boni, Lamberto, Pauwels, Jonathan E., Chen, Yanjiang, Planas-Paz, Lara, Shaw, Reid, Emerling, Brooke M., Grandori, Carla, Hopkins, Benjamin D., Rubin, Mark A.
Publicado 2022

EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma

por Durbin, Adam D., Wang, Tingjian, Wimalasena, Virangika K., Zimmerman, Mark W., Li, Deyao, Dharia, Neekesh V., Mariani, Luca, Shendy, Noha A.M., Nance, Stephanie, Patel, Anand G., Shao, Ying, Mundada, Maya, Maxham, Lily, Park, Paul M.C., Sigua, Logan H., Morita, Ken, Conway, Amy Saur, Robichaud, Amanda L., Perez-Atayde, Antonio R., Bikowitz, Melissa J., Quinn, Taylor R., Wiest, Olaf, Easton, John, Schönbrunn, Ernst, Bulyk, Martha L., Abraham, Brian J., Stegmaier, Kimberly, Look, A. Thomas, Qi, Jun
Publicado 2022

Independent Drug Action in Combination Therapy: Implications for Precision Oncology

por Plana, Deborah, Palmer, Adam C., Sorger, Peter K.
Publicado 2022

PTP1B Is an Intracellular Checkpoint that Limits T-cell and CAR T-cell Antitumor Immunity

por Wiede, Florian, Lu, Kun-Hui, Du, Xin, Zeissig, Mara N., Xu, Rachel, Goh, Pei Kee, Xirouchaki, Chrysovalantou E., Hogarth, Samuel J., Greatorex, Spencer, Sek, Kevin, Daly, Roger J., Beavis, Paul A., Darcy, Phillip K., Tonks, Nicholas K., Tiganis, Tony
Publicado 2022

BAMM (BRAF Autophagy and MEK Inhibition in Melanoma): A Phase I/II Trial of Dabrafenib, Trametinib, and Hydroxychloroquine in Advanced BRAFV600-mutant Melanoma

por Mehnert, Janice M., Mitchell, Tara C., Huang, Alexander C., Aleman, Tomas S., Kim, Benjamin J., Schuchter, Lynn M., Linette, Gerald P., Karakousis, Giorgos C., Mitnick, Sheryl, Giles, Lydia, Carberry, Mary, Frey, Noelle, Kossenkov, Andrew, Groisberg, Roman, Hernandez-Aya, Leonel F., Ansstas, George, Silk, Ann W., Chandra, Sunandana, Sosman, Jeffrey A., Gimotty, Phyllis A., Mick, Rosemarie, Amaravadi, Ravi K.
Publicado 2022

Prostaglandin Pathways: Opportunities for Cancer Prevention and Therapy

por Wang, Qiushi, Morris, Rebecca J., Bode, Ann M., Zhang, Tianshun
Publicado 2022