Pan-cancer Analysis of Homologous Recombination Repair–associated Gene Alterations and Genome-wide Loss-of-Heterozygosity Score

por Westphalen, C. Benedikt, Fine, Alexander D., André, Fabrice, Ganesan, Shridar, Heinemann, Volker, Rouleau, Etienne, Turnbull, Clare, Garcia Palacios, Luis, Lopez, Jorge-Antonio, Sokol, Ethan S., Mateo, Joaquin
Publicado 2022

Phase I Study of High-Dose l-Methylfolate in Combination with Temozolomide and Bevacizumab in Recurrent IDH Wild-Type High-Grade Glioma

por Salas, Lucas A., Stewart, Thomas G., Mobley, Bret C., Peng, Chengwei, Liu, Jing, Loganathan, Sudan N., Wang, Jialiang, Ma, Yanjun, Berger, Mitchel S., Absher, Devin, Hu, Yang, Moots, Paul L., Christensen, Brock C., Clark, Stephen W.
Publicado 2022

Small-Molecule NSC59984 Induces Mutant p53 Degradation through a ROS-ERK2-MDM2 Axis in Cancer Cells

por Zhang, Shengliang, Zhou, Lanlan, El-Deiry, Wafik S.
Publicado 2022

Targeting S100A9–ALDH1A1–Retinoic Acid Signaling to Suppress Brain Relapse in EGFR-Mutant Lung Cancer

por Biswas, Anup Kumar, Han, Seoyoung, Tai, Yifan, Ma, Wanchao, Coker, Courtney, Quinn, S. Aidan, Shakri, Ahmad Rushdi, Zhong, Timothy James, Scholze, Hanna, Lagos, Galina G., Mela, Angeliki, Manova-Todorova, Katia, de Stanchina, Elisa, Ferrando, Adolfo A., Mendelsohn, Cathy, Canoll, Peter, Yu, Helena A., Paik, Paul K., Saqi, Anjali, Shu, Catherine A., Kris, Mark G., Massague, Joan, Acharyya, Swarnali
Publicado 2022

MUC1-C Dictates JUN and BAF-Mediated Chromatin Remodeling at Enhancer Signatures in Cancer Stem Cells

por Bhattacharya, Atrayee, Fushimi, Atsushi, Yamashita, Nami, Hagiwara, Masayuki, Morimoto, Yoshihiro, Rajabi, Hasan, Long, Mark D., Abdulla, Maha, Ahmad, Rehan, Street, Kelly, Liu, Song, Liu, Tao, Kufe, Donald
Publicado 2022

A Urinary Drug-Disposing Approach as an Alternative to Intravesical Chemotherapy for Treating Nonmuscle Invasive Bladder Cancer

por Bellat, Vanessa, Michel, Adam O., Thomas, Charlene, Stokol, Tracy, Choi, Benjamin B., Law, Benedict
Publicado 2022

Hypoxia Drives Centrosome Amplification in Cancer Cells via HIF1α-dependent Induction of Polo-Like Kinase 4

por Mittal, Karuna, Kaur, Jaspreet, Sharma, Shaligram, Sharma, Nivya, Wei, Guanhao, Choudhary, Ishita, Imhansi-Jacob, Precious, Maganti, Nagini, Pawar, Shrikant, Rida, Padmashree, Toss, Michael S., Aleskandarany, Mohammed, Janssen, Emiel A., Søiland, Håvard, Gupta, Meenakshi. V., Reid, Michelle D., Rakha, Emad A., Aneja, Ritu
Publicado 2022

A Structure is Worth a Thousand Words: New Insights for RAS and RAF Regulation

por Simanshu, Dhirendra K., Morrison, Deborah K.
Publicado 2022

MIRO2 Regulates Prostate Cancer Cell Growth via GCN1-Dependent Stress Signaling

por Furnish, Madison, Boulton, Dillon P., Genther, Victoria, Grofova, Denisa, Ellinwood, Mitchell Lee, Romero, Lina, Lucia, M. Scott, Cramer, Scott D., Caino, M. Cecilia
Publicado 2022

Phase Separation Mediates NUP98 Fusion Oncoprotein Leukemic Transformation

por Chandra, Bappaditya, Michmerhuizen, Nicole L., Shirnekhi, Hazheen K., Tripathi, Swarnendu, Pioso, Brittany J., Baggett, David W., Mitrea, Diana M., Iacobucci, Ilaria, White, Michael R., Chen, Jingjing, Park, Cheon-Gil, Wu, Huiyun, Pounds, Stanley, Medyukhina, Anna, Khairy, Khaled, Gao, Qingsong, Qu, Chunxu, Abdelhamed, Sherif, Gorman, Scott D., Bawa, Simranjot, Maslanka, Carolyn, Kinger, Swati, Dogra, Priyanka, Ferrolino, Mylene C., Di Giacomo, Danika, Mecucci, Cristina, Klco, Jeffery M., Mullighan, Charles G., Kriwacki, Richard W.
Publicado 2022

Association of Genetic Ancestry and Molecular Signatures with Cancer Survival Disparities: A Pan-Cancer Analysis

por Lee, Kara Keun, Rishishwar, Lavanya, Ban, Dongjo, Nagar, Shashwat Deepali, Mariño-Ramírez, Leonardo, McDonald, John F., Jordan, I. King
Publicado 2022

Subversion of Serotonin Receptor Signaling in Osteoblasts by Kynurenine Drives Acute Myeloid Leukemia

por Galán-Díez, Marta, Borot, Florence, Ali, Abdullah Mahmood, Zhao, Junfei, Gil-Iturbe, Eva, Shan, Xiaochuan, Luo, Na, Liu, Yongfeng, Huang, Xi-Ping, Bisikirska, Brygida, Labella, Rossella, Kurland, Irwin, Roth, Bryan L., Quick, Matthias, Mukherjee, Siddhartha, Rabadán, Raul, Carroll, Martin, Raza, Azra, Kousteni, Stavroula
Publicado 2022

Intratumoral Delivery of STING Agonist Results in Clinical Responses in Canine Glioblastoma

por Boudreau, C. Elizabeth, Najem, Hinda, Ott, Martina, Horbinski, Craig, Fang, Dexing, DeRay, Chase M., Levine, Jonathan M., Curran, Michael A., Heimberger, Amy B.
Publicado 2021

Disrupting the MYC-TFEB Circuit Impairs Amino Acid Homeostasis and Provokes Metabolic Anergy

por Fernandez, Mario R., Schaub, Franz X., Yang, Chunying, Li, Weimin, Yun, Seongseok, Schaub, Stephanie K., Dorsey, Frank C., Liu, Min, Steeves, Meredith A., Ballabio, Andrea, Tzankov, Alexandar, Chen, Zhihua, Koomen, John M., Berglund, Anders E., Cleveland, John L.
Publicado 2022

Opening of the Blood–Brain Barrier Using Low-Intensity Pulsed Ultrasound Enhances Responses to Immunotherapy in Preclinical Glioma Models

por Sabbagh, Aria, Beccaria, Kevin, Ling, Xiaoyang, Marisetty, Anantha, Ott, Martina, Caruso, Hillary, Barton, Emily, Kong, Ling-Yuan, Fang, Dexing, Latha, Khatri, Zhang, Daniel Yang, Wei, Jun, DeGroot, John, Curran, Michael A., Rao, Ganesh, Hu, Jian, Desseaux, Carole, Bouchoux, Guillaume, Canney, Michael, Carpentier, Alexandre, Heimberger, Amy B.
Publicado 2021

Phase Ib Trial of the Combination of Imatinib and Binimetinib in Patients with Advanced Gastrointestinal Stromal Tumors

por Chi, Ping, Qin, Li-Xuan, Camacho, Niedzica, Kelly, Ciara M., D'Angelo, Sandra P., Dickson, Mark A., Gounder, Mrinal M., Keohan, Mary L., Movva, Sujana, Nacev, Benjamin A., Rosenbaum, Evan, Thornton, Katherine A., Crago, Aimee M., Francis, Jasmine H., Martindale, Moriah, Phelan, Haley T., Biniakewitz, Matthew D., Lee, Cindy J., Singer, Samuel, Hwang, Sinchun, Berger, Michael F., Chen, Yu, Antonescu, Cristina R., Tap, William D.
Publicado 2022

Dissecting the Oncogenic Roles of Keratin 17 in the Hallmarks of Cancer

por Baraks, Gabriella, Tseng, Robert, Pan, Chun-Hao, Kasliwal, Saumya, Leiton, Cindy V., Shroyer, Kenneth R., Escobar-Hoyos, Luisa F.
Publicado 2022

Understanding Drug Sensitivity and Tackling Resistance in Cancer

por Tyner, Jeffrey W., Haderk, Franziska, Kumaraswamy, Anbarasu, Baughn, Linda B., Van Ness, Brian, Liu, Song, Marathe, Himangi, Alumkal, Joshi J., Bivona, Trever G., Chan, Keith Syson, Druker, Brian J., Hutson, Alan D., Nelson, Peter S., Sawyers, Charles L., Willey, Christopher D.
Publicado 2022

Longitudinal SARS-CoV-2 mRNA Vaccine-Induced Humoral Immune Responses in Patients with Cancer

por Figueiredo, Jane C., Merin, Noah M., Hamid, Omid, Choi, So Yung, Lemos, Tucker, Cozen, Wendy, Nguyen, Nathalie, Finster, Laurel J., Foley, Joslyn, Darrah, Justin, Gong, Jun, Paquette, Ronald, Mita, Alain C., Vescio, Robert, Mehmi, Inderjit, Basho, Reva, Tourtellotte, Warren G., Huynh, Carissa A., Melmed, Gil Y., Braun, Jonathan, McGovern, Dermot P.B., Mengesha, Emebet, Botwin, Greg, Prostko, John C., Frias, Edwin C., Stewart, James L., Joung, Sandy, Van Eyk, Jennifer, Ebinger, Joseph E., Cheng, Susan, Sobhani, Kimia, Reckamp, Karen L., Merchant, Akil
Publicado 2021

Comprehensive Analysis of R-Spondin Fusions and RNF43 Mutations Implicate Novel Therapeutic Options in Colorectal Cancer

por Seeber, Andreas, Battaglin, Francesca, Zimmer, Kai, Kocher, Florian, Baca, Yasmine, Xiu, Joanne, Spizzo, Gilbert, Novotny-Diermayr, Veronica, Rieder, Dietmar, Puccini, Alberto, Swensen, Jeff, Ellis, Michelle, Goldberg, Richard M., Grothey, Axel, Shields, Anthony F., Marshall, John L., Weinberg, Benjamin A., Sackstein, Paul E., Lim, Kiat Hon, Tan, Gek San, Nabhan, Chadi, Korn, W. Michael, Amann, Arno, Trajanoski, Zlatko, Berger, Martin D., Lou, Emil, Wolf, Dominik, Lenz, Heinz-Josef
Publicado 2022