Exploiting LRRC15 as a Novel Therapeutic Target in Cancer

por Ray, Upasana, Pathoulas, Christopher L., Thirusangu, Prabhu, Purcell, James W., Kannan, Nagarajan, Shridhar, Viji
Publicado 2022

Predictable Clinical Benefits without Evidence of Synergy in Trials of Combination Therapies with Immune-Checkpoint Inhibitors

por Palmer, Adam C., Izar, Benjamin, Hwangbo, Haeun, Sorger, Peter K.
Publicado 2022

Diminished Immune Surveillance during Histologic Progression of Intraductal Papillary Mucinous Neoplasms Offers a Therapeutic Opportunity for Cancer Interception

por Hernandez, Sharia, Parra, Edwin Roger, Uraoka, Naohiro, Tang, Ximing, Shen, Yu, Qiao, Wei, Jiang, Mei, Zhang, Shanyu, Mino, Barbara, Lu, Wei, Pandurengan, Renganayaki, Haymaker, Cara, Affolter, Kajsa, Scaife, Courtney L., Yip-Schneider, Michele, Schmidt, C. Max, Firpo, Matthew A., Mulvihill, Sean J., Koay, Eugene J., Wang, Huamin, Wistuba, Ignacio I., Maitra, Anirban, Solis, Luisa M., Sen, Subrata
Publicado 2022

The Genetic Landscape of Ocular Adnexa MALT Lymphoma Reveals Frequent Aberrations in NFAT and MEF2B Signaling Pathways

por Magistri, Marco, Happ, Lanie E., Ramdial, Jeremy, Lu, XiaoQing, Stathias, Vasileios, Kunkalla, Kranthi, Agarwal, Nitin, Jiang, Xiaoyu, Schürer, Stephan C., Dubovy, Sander R., Chapman, Jennifer R., Vega, Francisco, Dave, Sandeep, Lossos, Izidore S.
Publicado 2021

Assessing the Coverage of US Cancer Center Primary Catchment Areas

por Leader, Amy E., McNair, Christopher, Yurick, Christina, Huesser, Matthew, Schade, Elizabeth, Stimmel, Emily E., Lerman, Caryn, Knudsen, Karen E.
Publicado 2022

Optimal Strategy and Benefit of Pulsed Therapy Depend On Tumor Heterogeneity and Aggressiveness at Time of Treatment Initiation

por Mathur, Deepti, Taylor, Bradford P., Chatila, Walid K., Scher, Howard I., Schultz, Nikolaus, Razavi, Pedram, Xavier, Joao B.
Publicado 2022

B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS

por Wang, Sophia S., Vajdic, Claire M., Linet, Martha S., Slager, Susan L., Voutsinas, Jenna, Nieters, Alexandra, Casabonne, Delphine, Cerhan, James R., Cozen, Wendy, Alarcón, Graciela, Martínez-Maza, Otoniel, Brown, Elizabeth E., Bracci, Paige M., Turner, Jennifer, Hjalgrim, Henrik, Bhatti, Parveen, Zhang, Yawei, Birmann, Brenda M., Flowers, Christopher R., Paltiel, Ora, Holly, Elizabeth A., Kane, Eleanor, Weisenburger, Dennis D., Maynadié, Marc, Cocco, Pierluigi, Foretova, Lenka, Breen, Elizabeth Crabb, Lan, Qing, Brooks-Wilson, Angela, De Roos, Anneclaire J., Smith, Martyn T., Roman, Eve, Boffetta, Paolo, Kricker, Anne, Zheng, Tongzhang, Skibola, Christine F., Clavel, Jacqueline, Monnereau, Alain, Chanock, Stephen J., Rothman, Nathaniel, Benavente, Yolanda, Hartge, Patricia, Smedby, Karin E.
Publicado 2022

Inhibitor of the Nuclear Transport Protein XPO1 Enhances the Anticancer Efficacy of KRAS G12C Inhibitors in Preclinical Models of KRAS G12C–Mutant Cancers

por Khan, Husain Yar, Nagasaka, Misako, Li, Yiwei, Aboukameel, Amro, Uddin, Md. Hafiz, Sexton, Rachel, Bannoura, Sahar, Mzannar, Yousef, Al-Hallak, Mohammed Najeeb, Kim, Steve, Beydoun, Rafic, Landesman, Yosef, Mamdani, Hirva, Uprety, Dipesh, Philip, Philip A., Mohammad, Ramzi M., Shields, Anthony F., Azmi, Asfar S.
Publicado 2022

Nuclear Receptor 4A2 (NR4A2/NURR1) Regulates Autophagy and Chemoresistance in Pancreatic Ductal Adenocarcinoma

por Zarei, Mehrdad, Shrestha, Rupesh, Johnson, Sneha, Yu, Zuhua, Karki, Keshav, Vaziri-Gohar, Ali, Epps, Jessica, Du, Heng, Suva, Larry, Zarei, Mahsa, Safe, Stephen
Publicado 2021

8-Azaadenosine and 8-Chloroadenosine are not Selective Inhibitors of ADAR

por Cottrell, Kyle A., Soto-Torres, Luisangely, Dizon, Michael G., Weber, Jason D.
Publicado 2021

Induction of Synthetic Lethality by Activation of Mitochondrial ClpP and Inhibition of HDAC1/2 in Glioblastoma

por Nguyen, Trang T.T., Shang, Enyuan, Schiffgens, Salveena, Torrini, Consuelo, Shu, Chang, Akman, Hasan Orhan, Prabhu, Varun V., Allen, Joshua E., Westhoff, Mike-Andrew, Karpel-Massler, Georg, Siegelin, Markus D.
Publicado 2022

Leveraging Allele-Specific Expression for Therapeutic Response Gene Discovery in Glioblastoma

por Sen, Arko, Prager, Briana C., Zhong, Cuiqing, Park, Donglim, Zhu, Zhe, Gimple, Ryan C., Wu, Qiulian, Bernatchez, Jean A., Beck, Sungjun, Clark, Alex E., Siqueira-Neto, Jair L., Rich, Jeremy N., McVicker, Graham
Publicado 2022

In Silico Epitope Prediction Analyses Highlight the Potential for Distracting Antigen Immunodominance with Allogeneic Cancer Vaccines

por James, C. Alston, Ronning, Peter, Cullinan, Darren, Cotto, Kelsy C., Barnell, Erica K., Campbell, Katie M., Skidmore, Zachary L., Sanford, Dominic E., Goedegebuure, S. Peter, Gillanders, William E., Griffith, Obi L., Hawkins, William G., Griffith, Malachi
Publicado 2021

cfTrack: A Method of Exome-Wide Mutation Analysis of Cell-free DNA to Simultaneously Monitor the Full Spectrum of Cancer Treatment Outcomes Including MRD, Recurrence, and Evolution

por Li, Shuo, Zeng, Weihua, Ni, Xiaohui, Zhou, Yonggang, Stackpole, Mary L., Noor, Zorawar S., Yuan, Zuyang, Neal, Adam, Memarzadeh, Sanaz, Garon, Edward B., Dubinett, Steven M., Li, Wenyuan, Zhou, Xianghong Jasmine
Publicado 2022

Building Tools for Machine Learning and Artificial Intelligence in Cancer Research: Best Practices and a Case Study with the PathML Toolkit for Computational Pathology

por Rosenthal, Jacob, Carelli, Ryan, Omar, Mohamed, Brundage, David, Halbert, Ella, Nyman, Jackson, Hari, Surya N., Van Allen, Eliezer M., Marchionni, Luigi, Umeton, Renato, Loda, Massimo
Publicado 2022

p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade

por Molkentine, David P., Molkentine, Jessica M., Bridges, Kathleen A., Valdecanas, David R., Dhawan, Annika, Bahri, Reshub, Hefner, Andrew J., Kumar, Manish, Yang, Liangpeng, Abdelhakiem, Mohamed, Pifer, Phillip M., Sandulache, Vlad, Sheth, Aakash, Beadle, Beth M., Thames, Howard D., Mason, Kathryn A., Pickering, Curtis R., Meyn, Raymond E., Skinner, Heath D.
Publicado 2022

Ecdysoneless Protein Regulates Viral and Cellular mRNA Splicing to Promote Cervical Oncogenesis

por Mirza, Sameer, Kalluchi, Achyuth, Raza, Mohsin, Saleem, Irfana, Mohapatra, Bhopal, Pal, Dhananjaya, Ouellette, Michel M., Qiu, Fang, Yu, Lulu, Lobanov, Alexei, Zheng, Zhi-Ming, Zhang, Ying, Alsaleem, Mansour A., Rakha, Emad A., Band, Hamid, Rowley, M. Jordan, Band, Vimla
Publicado 2022

BHLHE40 Regulates the T-Cell Effector Function Required for Tumor Microenvironment Remodeling and Immune Checkpoint Therapy Efficacy

por Salmon, Avery J., Shavkunov, Alexander S., Miao, Qi, Jarjour, Nicholas N., Keshari, Sunita, Esaulova, Ekaterina, Williams, Charmelle D., Ward, Jeffrey P., Highsmith, Anna M., Pineda, Josué E., Taneja, Reshma, Chen, Ken, Edelson, Brian T., Gubin, Matthew M.
Publicado 2022

Infigratinib in Patients with Recurrent Gliomas and FGFR Alterations: A Multicenter Phase II Study

por Lassman, Andrew B., Sepúlveda-Sánchez, Juan Manuel, Cloughesy, Timothy F., Gil-Gil, Miguel J., Puduvalli, Vinay K., Raizer, Jeffrey J., De Vos, Filip Y.F., Wen, Patrick Y., Butowski, Nicholas A., Clement, Paul M.J., Groves, Morris D., Belda-Iniesta, Cristóbal, Giglio, Pierre, Soifer, Harris S., Rowsey, Steven, Xu, Cindy, Avogadri, Francesca, Wei, Ge, Moran, Susan, Roth, Patrick
Publicado 2022

Comprehensive Surfaceome Profiling to Identify and Validate Novel Cell-Surface Targets in Osteosarcoma

por Wang, Yifei, Tian, Xiangjun, Zhang, Wendong, Zhang, Zhongting, Lazcano, Rossana, Hingorani, Pooja, Roth, Michael E., Gill, Jonathan D., Harrison, Douglas J., Xu, Zhaohui, Jusu, Sylvester, Kannan, Sankaranarayanan, Wang, Jing, Lazar, Alexander J., Earley, Eric J., Erickson, Stephen W., Gelb, Tara, Huxley, Philip, Lahdenranta, Johanna, Mudd, Gemma, Kurmasheva, Raushan T., Houghton, Peter J., Smith, Malcolm A., Kolb, Edward A., Gorlick, Richard
Publicado 2022