Differentiating Inhibition Selectivity and Binding Affinity of Isocitrate Dehydrogenase 1 Variant Inhibitors

por Liu, Shuang, Abboud, Martine, Mikhailov, Victor, Liu, Xiao, Reinbold, Raphael, Schofield, Christopher J.
Publicado 2023

Modulation of ERK5 Activity as a Therapeutic Anti-Cancer Strategy

por Miller, Duncan C., Harnor, Suzannah J., Martin, Mathew P., Noble, Richard A., Wedge, Stephen R., Cano, Celine
Publicado 2023

Heterobifunctional Ligase Recruiters Enable pan-Degradation of Inhibitor of Apoptosis Proteins

por Ng, Yuen Lam Dora, Bricelj, Aleša, Jansen, Jacqueline A., Murgai, Arunima, Peter, Kirsten, Donovan, Katherine A., Gütschow, Michael, Krönke, Jan, Steinebach, Christian, Sosič, Izidor
Publicado 2023

Computational Investigations into Two-Photon Fibril Imaging Using the DANIR-2c Probe

por Murugan, N. Arul, Zaleśny, Robert
Publicado 2023

Small-Molecule Fluorescent Ligands for the CXCR4 Chemokine Receptor

por Dekkers, Sebastian, Caspar, Birgit, Goulding, Joëlle, Kindon, Nicholas D., Kilpatrick, Laura E., Stoddart, Leigh A., Briddon, Stephen J., Kellam, Barrie, Hill, Stephen J., Stocks, Michael J.
Publicado 2023

Oldie but Goodie: Is Technetium-99m Still a Treasure Trove of Innovation for Medicine? A Patents Analysis (2000–2022)

por Riondato, Mattia, Rigamonti, Dorotea, Martini, Petra, Cittanti, Corrado, Boschi, Alessandra, Urso, Luca, Uccelli, Licia
Publicado 2023

Conserved Conformational Dynamics Reveal a Key Dynamic Residue in the Gatekeeper Loop of Human Cyclophilins

por Ahmed, Furyal, Yao, Xin-Qiu, Hamelberg, Donald
Publicado 2023

Design and Pharmacological Characterization of α(4)β(1) Integrin Cyclopeptide Agonists: Computational Investigation of Ligand Determinants for Agonism versus Antagonism

por Anselmi, Michele, Baiula, Monica, Spampinato, Santi, Artali, Roberto, He, Tingting, Gentilucci, Luca
Publicado 2023

Modeling the Effect of Disorder in the Two-Dimensional Electronic Spectroscopy of Poly-3-hexyltiophene in an Organic Photovoltaic Blend: A Combined Quantum/Classical Approach

por Palacino-González, Elisa, Jansen, Thomas L. C.
Publicado 2023

Frequency-Domain Method for Characterization of Upconversion Luminescence Kinetics

por Labrador-Páez, Lucía, Kankare, Jouko, Hyppänen, Iko, Soukka, Tero, Andresen, Elina, Resch-Genger, Ute, Widengren, Jerker, Liu, Haichun
Publicado 2023

Cooperative Change in the Internal Dynamics of Streptavidin Caused by Biotin Binding

por Sarter, Mona
Publicado 2023

Anticancer Activity of Region B Capsaicin Analogs

por Brown, Kathleen C., Modi, Kushal J., Light, Reagan S., Cox, Ashley J., Long, Timothy E., Gadepalli, Rama S., Rimoldi, John M., Miles, Sarah L., Rankin, Gary, Valentovic, Monica, Denning, Krista L., Tirona, Maria T., Finch, Paul T., Hess, Joshua A., Dasgupta, Piyali
Publicado 2023

BAY-6096: A Potent, Selective, and Highly Water-Soluble Adrenergic α(2B) Antagonist

por Meibom, Daniel, Meyer, Jutta, von Buehler, Clemens-Jeremias, Collins, Karl D., Maassen, Stefanie, Gericke, Kersten Matthias, Hüser, Jörg, Mittendorf, Joachim, Ortega Hernandez, Nuria, Schamberger, Jens, Stampfuss, Jan, Straub, Alexander, Torge, Afra, Witowski, Norbert, Wunder, Frank
Publicado 2023

Discovery of Nanomolar DCAF1 Small Molecule Ligands

por Li, Alice Shi Ming, Kimani, Serah, Wilson, Brian, Noureldin, Mahmoud, González-Álvarez, Héctor, Mamai, Ahmed, Hoffer, Laurent, Guilinger, John P., Zhang, Ying, von Rechenberg, Moritz, Disch, Jeremy S., Mulhern, Christopher J., Slakman, Belinda L., Cuozzo, John W., Dong, Aiping, Poda, Gennady, Mohammed, Mohammed, Saraon, Punit, Mittal, Manish, Modh, Pratik, Rathod, Vaibhavi, Patel, Bhashant, Ackloo, Suzanne, Santhakumar, Vijayaratnam, Szewczyk, Magdalena M, Barsyte-Lovejoy, Dalia, Arrowsmith, Cheryl H., Marcellus, Richard, Guié, Marie-Aude, Keefe, Anthony D., Brown, Peter J., Halabelian, Levon, Al-awar, Rima, Vedadi, Masoud
Publicado 2023

Expanding the Paradigm of Structure-Based Drug Design: Molecular Dynamics Simulations Support the Development of New Pyridine-Based Protein Kinase C-Targeted Agonists

por Lautala, Saara, Provenzani, Riccardo, Tarvainen, Ilari, Sirna, Katia, Karhu, S. Tuuli, Grazhdankin, Evgeni, Lehtinen, Antti K., Sa’d, Hanan, Koivuniemi, Artturi, Xhaard, Henri, Tuominen, Raimo K., Talman, Virpi, Bunker, Alex, Yli-Kauhaluoma, Jari
Publicado 2023

LIGHT-SABRE Hyperpolarizes 1-(13)C-Pyruvate Continuously without Magnetic Field Cycling

por Pravdivtsev, Andrey N., Buckenmaier, Kai, Kempf, Nicolas, Stevanato, Gabriele, Scheffler, Klaus, Engelmann, Joern, Plaumann, Markus, Koerber, Rainer, Hövener, Jan-Bernd, Theis, Thomas
Publicado 2023

Serine-/Cysteine-Based sp(2)-Iminoglycolipids as Novel TLR4 Agonists: Evaluation of Their Adjuvancy and Immunotherapeutic Properties in a Murine Model of Asthma

por González-Cuesta, Manuel, Lai, Alan Chuan-Ying, Chi, Po-Yu, Hsu, I-Ling, Liu, Nien-Tzu, Wu, Ko-Chien, García Fernández, José M., Chang, Ya-Jen, Ortiz Mellet, Carmen
Publicado 2023

Chirality-Induced Spin Selectivity (CISS) Effect: Magnetocurrent–Voltage Characteristics with Coulomb Interactions I

por Huisman, Karssien Hero, Heinisch, Jan-Brian Mi-Yu, Thijssen, Joseph Marie
Publicado 2023

Designing Smaller, Synthetic, Functional Mimetics of Sulfated Glycosaminoglycans as Allosteric Modulators of Coagulation Factors

por Abdelfadiel, Elsamani I., Gunta, Rama, Villuri, Bharath Kumar, Afosah, Daniel K., Sankaranarayanan, Nehru Viji, Desai, Umesh R.
Publicado 2023

Photoisomerization of Heptamethine Cyanine Dyes Results in Red-Emissive Species: Implications for Near-IR, Single-Molecule, and Super-Resolution Fluorescence Spectroscopy and Imagi...

por Sandberg, Elin, Piguet, Joachim, Kostiv, Uliana, Baryshnikov, Glib, Liu, Haichun, Widengren, Jerker
Publicado 2023