Dirhodium(II)/Phosphine Catalyst with Chiral Environment at Bridging Site and Its Application in Enantioselective Atropisomer Synthesis

por Shi, Lei, Xue, Xiaoping, Hong, Biqiong, Li, Qigang, Gu, Zhenhua
Publicado 2023

An Ecosystem for Digital Reticular Chemistry

por Jablonka, Kevin Maik, Rosen, Andrew S., Krishnapriyan, Aditi S., Smit, Berend
Publicado 2023

Glow-in-the-Dark Infectious Disease Diagnostics Using CRISPR-Cas9-Based Split Luciferase Complementation

por van der Veer, Harmen J., van Aalen, Eva A., Michielsen, Claire M. S., Hanckmann, Eva T. L., Deckers, Jeroen, van Borren, Marcel M. G. J., Flipse, Jacky, Loonen, Anne J. M., Schoeber, Joost P. H., Merkx, Maarten
Publicado 2023

Tris(hydroxymethyl)aminomethane Linker-Bearing Triazine-Based Triglucosides for Solubilization and Stabilization of Membrane Proteins

por Ghani, Lubna, Zhang, Xiang, Munk, Chastine F., Hariharan, Parameswaran, Lan, Baoliang, Yun, Hong Sik, Byrne, Bernadette, Guan, Lan, Loland, Claus J., Liu, Xiangyu, Chae, Pil Seok
Publicado 2023

Spotlight on Genetic Kidney Diseases: A Call for Drug Delivery and Nanomedicine Solutions

por Trac, Noah, Ashraf, Anisa, Giblin, Joshua, Prakash, Supriya, Mitragotri, Samir, Chung, Eun Ji
Publicado 2023

Conserved Protein–Polymer Interactions across Structurally Diverse Polymers Underlie Alterations to Protein Thermal Unfolding

por Pritzlaff, Amanda, Ferré, Guillaume, Dargassies, Elia, Williams, Crystal O., Gonzalez, Daniel D., Eddy, Matthew T.
Publicado 2023

Linearization of the Brevicidine and Laterocidine Lipopeptides Yields Analogues That Retain Full Antibacterial Activity

por Ballantine, Ross D., Al Ayed, Karol, Bann, Samantha J., Hoekstra, Michael, Martin, Nathaniel I., Cochrane, Stephen A.
Publicado 2023

Enhanced Antifungal Activity of Amphotericin B Bound to Albumin: A “Trojan Horse” Effect of the Protein

por Grela, Ewa, Stączek, Sylwia, Nowak, Monika, Pawlikowska-Pawlega, Bozena, Zdybicka-Barabas, Agnieszka, Janik, Sebastian, Cytryńska, Małgorzata, Grudzinski, Wojciech, Gruszecki, Wieslaw I., Luchowski, Rafal
Publicado 2023

Native Function of the Bacterial Ion Channel SthK in a Sparsely Tethered Lipid Bilayer Membrane Architecture

por Andersson, Jakob, Kleinheinz, David, Ramach, Ulrich, Kiesenhofer, Nikolaus, Ashenden, Alex, Valtiner, Markus, Holt, Stephen, Koeper, Ingo, Schmidpeter, Philipp A. M., Knoll, Wolfgang
Publicado 2023

Multiscale Modeling of Spheroid Tumors: Effect of Nutrient Availability on Tumor Evolution

por Rosenbauer, Jakob, Berghoff, Marco, Glazier, James A., Schug, Alexander
Publicado 2023

Optimized OPEP Force Field for Simulation of Crowded Protein Solutions

por Timr, Stepan, Melchionna, Simone, Derreumaux, Philippe, Sterpone, Fabio
Publicado 2023

N′-Phenylacetohydrazide Derivatives as Potent Ebola Virus Entry Inhibitors with an Improved Pharmacokinetic Profile

por Garcia-Rubia, Alfonso, Lasala, Fátima, Ginex, Tiziana, Morales-Tenorio, Marcos, Olal, Catherine, Heung, Michelle, Oquist, Paola, Galindo, Inmaculada, Cuesta-Geijo, Miguel Ángel, Casasnovas, José M., Campillo, Nuria E., Canales, Ángeles, Alonso, Covadonga, Martínez, Ana, Muñoz-Fontela, César, Delgado, Rafael, Gil, Carmen
Publicado 2023

Macrocycles in Drug Discovery—Learning from the Past for the Future

por Garcia Jimenez, Diego, Poongavanam, Vasanthanathan, Kihlberg, Jan
Publicado 2023

Tuning the Photophysical Properties of Ru(II) Photosensitizers for PDT by Protonation and Metallation: A DFT Study

por Spiegel, Maciej, Adamo, Carlo
Publicado 2023

Catalytically Active Snake Venom PLA(2) Enzymes: An Overview of Its Elusive Mechanisms of Reaction: Miniperspective

por Castro-Amorim, Juliana, Novo de Oliveira, Ana, Da Silva, Saulo Luís, Soares, Andreimar M., Mukherjee, Ashis K., Ramos, Maria João, Fernandes, Pedro A.
Publicado 2023

Novel Synthesis of C-Methylated Phytocannabinoids Bearing Anti-inflammatory Properties

por Lavi, Yarden, Kogan, Natalya M., Topping, Louise M., Liu, Caojie, McCann, Fiona E., Williams, Richard O., Breuer, Aviva, Yekhtin, Zhanna, Ezra, Aviva Friedman, Gallily, Ruth, Feldmann, Marc, Mechoulam, Raphael
Publicado 2023

HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies

por Pasqua, A. Elisa, Sharp, Swee Y., Chessum, Nicola E. A., Hayes, Angela, Pellegrino, Loredana, Tucker, Michael J., Miah, Asadh, Wilding, Birgit, Evans, Lindsay E., Rye, Carl S., Mok, N. Yi, Liu, Manjuan, Henley, Alan T., Gowan, Sharon, De Billy, Emmanuel, te Poele, Robert, Powers, Marissa, Eccles, Suzanne A., Clarke, Paul A., Raynaud, Florence I., Workman, Paul, Jones, Keith, Cheeseman, Matthew D.
Publicado 2023

Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones

por Harnden, Alice C., Davis, Owen A., Box, Gary M., Hayes, Angela, Johnson, Louise D., Henley, Alan T., de Haven Brandon, Alexis K., Valenti, Melanie, Cheung, Kwai-Ming J., Brennan, Alfie, Huckvale, Rosemary, Pierrat, Olivier A., Talbot, Rachel, Bright, Michael D., Akpinar, Hafize Aysin, Miller, Daniel S. J., Tarantino, Dalia, Gowan, Sharon, de Klerk, Selby, McAndrew, Peter Craig, Le Bihan, Yann-Vaï, Meniconi, Mirco, Burke, Rosemary, Kirkin, Vladimir, van Montfort, Rob L. M., Raynaud, Florence I., Rossanese, Olivia W., Bellenie, Benjamin R., Hoelder, Swen
Publicado 2023

Design, Synthesis, In Vitro and In Vivo Characterization of CDC42 GTPase Interaction Inhibitors for the Treatment of Cancer

por Brindani, Nicoletta, Vuong, Linh M., Acquistapace, Isabella Maria, La Serra, Maria Antonietta, Ortega, José Antonio, Veronesi, Marina, Bertozzi, Sine Mandrup, Summa, Maria, Girotto, Stefania, Bertorelli, Rosalia, Armirotti, Andrea, Ganesan, Anand K., De Vivo, Marco
Publicado 2023

Dynamical Simulations of Carotenoid Photoexcited States Using Density Matrix Renormalization Group Techniques

por Manawadu, Dilhan, Valentine, Darren J., Barford, William
Publicado 2023