Rethinking the Goals of Diabetes Prevention Programs

por Mezuk, Briana, Allen, Julie Ober
Publicado 2021

A Biomarker-Based Score for Risk of Hospitalization for Heart Failure in Patients With Diabetes

por Berg, David D., Wiviott, Stephen D., Scirica, Benjamin M., Zelniker, Thomas A., Goodrich, Erica L., Jarolim, Petr, Mosenzon, Ofri, Cahn, Avivit, Bhatt, Deepak L., Leiter, Lawrence A., McGuire, Darren K., Wilding, John P.H., Johanson, Per, Langkilde, Anna Maria, Raz, Itamar, Braunwald, Eugene, Sabatine, Marc S., Morrow, David A.
Publicado 2021

Adult-Onset Type 1 Diabetes: Current Understanding and Challenges

por Leslie, R. David, Evans-Molina, Carmella, Freund-Brown, Jacquelyn, Buzzetti, Raffaella, Dabelea, Dana, Gillespie, Kathleen M., Goland, Robin, Jones, Angus G., Kacher, Mark, Phillips, Lawrence S., Rolandsson, Olov, Wardian, Jana L., Dunne, Jessica L.
Publicado 2021

Minimal Model–Derived Insulin Sensitivity Index Underestimates Insulin Sensitivity in Black Americans

por Fosam, Andin, Yuditskaya, Susan, Sarcone, Camila, Grewal, Shivraj, Fan, Hubert, Muniyappa, Ranganath
Publicado 2021

Incidence of Type 1 Diabetes May Be Underestimated in the Chinese Population: Evidence From 21.7 Million People Between 2007 and 2017

por Liu, Chang, Yuan, Ying-Chao, Guo, Mo-Ning, Xin, Zhong, Chen, Guan-Jie, Bentley, Amy R., Hua, Lin, Zheng, Jian-Peng, Ekoru, Kenneth, Yang, Jin-Kui
Publicado 2021

Early Menopause and Cardiovascular Disease Risk in Women With or Without Type 2 Diabetes: A Pooled Analysis of 9,374 Postmenopausal Women

por Yoshida, Yilin, Chen, Zhipeng, Baudier, Robin L., Krousel-Wood, Marie, Anderson, Amanda H., Fonseca, Vivian A., Mauvais-Jarvis, Franck
Publicado 2021

Impaired Awareness of Hypoglycemia and Severe Hypoglycemia in Drivers With Diabetes: Insights From the Association of British Clinical Diabetologists Nationwide Audit

por Deshmukh, Harshal, Wilmot, Emma G., Choudhary, Pratik, Narendran, Parth, Shah, Najeeb, Barnes, Dennis, Kamruddin, Shafie, Banatwalla, Rumaisa, Christian, Peter, Saunders, Simon, Lumb, Alistair, Herring, Roselle, Patmore, Jane, Walton, Chris, Ryder, Robert E.J., Sathyapalan, Thozhukat
Publicado 2021

Living Dangerously: Protective and Harmful ER Stress Responses in Pancreatic β-Cells

por Sharma, Rohit B., Landa-Galván, Huguet V., Alonso, Laura C.
Publicado 2021

Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the GIPR Region

por Bowker, Nicholas, Hansford, Robert, Burgess, Stephen, Foley, Christopher N., Auyeung, Victoria P.W., Erzurumluoglu, A. Mesut, Stewart, Isobel D., Wheeler, Eleanor, Pietzner, Maik, Gribble, Fiona, Reimann, Frank, Bhatnagar, Pallav, Coghlan, Matthew P., Wareham, Nicholas J., Langenberg, Claudia
Publicado 2021

ENTPD3 Marks Mature Stem Cell–Derived β-Cells Formed by Self-Aggregation In Vitro

por Docherty, Fiona M., Riemondy, Kent A., Castro-Gutierrez, Roberto, Dwulet, JaeAnn M., Shilleh, Ali H., Hansen, Maria S., Williams, Shane P.M., Armitage, Lucas H., Santostefano, Katherine E., Wallet, Mark A., Mathews, Clayton E., Triolo, Taylor M., Benninger, Richard K.P., Russ, Holger A.
Publicado 2021

Lipid Droplets Protect Human β-Cells From Lipotoxicity-Induced Stress and Cell Identity Changes

por Tong, Xin, Stein, Roland
Publicado 2021

Cavβ3 Regulates Ca(2+) Signaling and Insulin Expression in Pancreatic β-Cells in a Cell-Autonomous Manner

por Becker, Alexander, Wardas, Barbara, Salah, Houssein, Amini, Maryam, Fecher-Trost, Claudia, Sen, Qiao, Martus, Damian, Beck, Andreas, Philipp, Stephan E., Flockerzi, Veit, Belkacemi, Anouar
Publicado 2021

Predisposition to Proinsulin Misfolding as a Genetic Risk to Diet-Induced Diabetes

por Alam, Maroof, Arunagiri, Anoop, Haataja, Leena, Torres, Mauricio, Larkin, Dennis, Kappler, John, Jin, Niyun, Arvan, Peter
Publicado 2021

β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet–Fed Mice

por Lin, Haopeng, Smith, Nancy, Spigelman, Aliya F., Suzuki, Kunimasa, Ferdaoussi, Mourad, Alghamdi, Tamadher A., Lewandowski, Sophie L., Jin, Yaxing, Bautista, Austin, Wang, Ying Wayne, Manning Fox, Jocelyn E., Merrins, Matthew J., Buteau, Jean, MacDonald, Patrick E.
Publicado 2021

Diabetes: Concepts of β-Cell Organ Dysfunction and Failure Would Lead to Earlier Diagnoses and Prevention

por Charles, M. Arthur, Leslie, R. David
Publicado 2021

GIP Receptor Agonism Attenuates GLP-1 Receptor Agonist–Induced Nausea and Emesis in Preclinical Models

por Borner, Tito, Geisler, Caroline E., Fortin, Samantha M., Cosgrove, Richard, Alsina-Fernandez, Jorge, Dogra, Mridula, Doebley, Sarah, Sanchez-Navarro, Marcos J., Leon, Rosa M., Gaisinsky, Jane, White, Arianna, Bamezai, Ankur, Ghidewon, Misgana Y., Grill, Harvey J., Crist, Richard C., Reiner, Benjamin C., Ai, Minrong, Samms, Ricardo J., De Jonghe, Bart C., Hayes, Matthew R.
Publicado 2021

Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study

por Slieker, Roderick C., Donnelly, Louise A., Fitipaldi, Hugo, Bouland, Gerard A., Giordano, Giuseppe N., Åkerlund, Mikael, Gerl, Mathias J., Ahlqvist, Emma, Ali, Ashfaq, Dragan, Iulian, Elders, Petra, Festa, Andreas, Hansen, Michael K., van der Heijden, Amber A., Mansour Aly, Dina, Kim, Min, Kuznetsov, Dmitry, Mehl, Florence, Klose, Christian, Simons, Kai, Pavo, Imre, Pullen, Timothy J., Suvitaival, Tommi, Wretlind, Asger, Rossing, Peter, Lyssenko, Valeriya, Legido Quigley, Cristina, Groop, Leif, Thorens, Bernard, Franks, Paul W., Ibberson, Mark, Rutter, Guy A., Beulens, Joline W.J., ’t Hart, Leen M., Pearson, Ewan R.
Publicado 2021

Activation of HIF1α Rescues the Hypoxic Response and Reverses Metabolic Dysfunction in the Diabetic Heart

por Sousa Fialho, Maria da Luz, Purnama, Ujang, Dennis, Kaitlyn M.J.H., Montes Aparicio, Claudia N., Castro-Guarda, Marcos, Massourides, Emmanuelle, Tyler, Damian J., Carr, Carolyn A., Heather, Lisa C.
Publicado 2021

SCO-267, a GPR40 Full Agonist, Stimulates Islet and Gut Hormone Secretion and Improves Glycemic Control in Humans

por Nishizaki, Harunobu, Matsuoka, Osamu, Kagawa, Tomoya, Kobayashi, Akihiro, Watanabe, Masanori, Moritoh, Yusuke
Publicado 2021

Stratification of Type 2 Diabetes by Age of Diagnosis in the UK Biobank Reveals Subgroup-Specific Genetic Associations and Causal Risk Profiles

por Noordam, Raymond, Läll, Kristi, Smit, Roelof A.J., Laisk, Triin, Metspalu, Andres, Esko, Tõnu, Milani, Lili, Loos, Ruth J.F., Mägi, Reedik, Willems van Dijk, Ko, van Heemst, Diana
Publicado 2021