Proteasome activator 28γ (PA28γ) allosterically activates trypsin-like proteolysis by binding to the α-ring of the 20S proteasome

por Thomas, Taylor A., Smith, David M.
Publicado 2022

Nuclear ribonucleoprotein RALY targets virus nucleocapsid protein and induces autophagy to restrict porcine epidemic diarrhea virus replication

por Qin, Wenzhen, Kong, Ning, Zhang, Yu, Dong, Sujie, Zhai, Huanjie, Zhai, Xueying, Yang, Xinyu, Ye, Chenqian, Ye, Manqing, Liu, Changlong, Yu, Lingxue, Zheng, Hao, Yu, Hai, Zhang, Wen, Tong, Guangzhi, Lan, Daoliang, Tong, Wu, Shan, Tongling
Publicado 2022

Phosphorylation on Syk Y342 is important for both ITAM and hemITAM signaling in platelets

por Kostyak, John C., Mauri, Benjamin, Dangelmaier, Carol, Vari, Hymavathi Reddy, Patel, Akruti, Wright, Monica, Reddy, Haritha, Tsygankov, Alexander Y., Kunapuli, Satya P.
Publicado 2022

Structural insights into the function-modulating effects of nanobody binding to the integrin receptor α(M)β(2)

por Jensen, Rasmus K., Pedersen, Henrik, Lorentzen, Josefine, Laursen, Nick Stub, Vorup-Jensen, Thomas, Andersen, Gregers Rom
Publicado 2022

Development of a universal antibiotic resistance screening reporter for improving efficiency of cytosine and adenine base editing

por Ma, Lixia, Xing, Jiani, Li, Qian, Zhang, Zhiying, Xu, Kun
Publicado 2022

Hypoxia-inducible factor-1α and poly [ADP ribose] polymerase 1 cooperatively regulate Notch3 expression under hypoxia via a noncanonical mechanism

por Nakamura, Hideaki, Sekine, Hiroki, Kato, Hiroyuki, Masai, Hisao, Gradin, Katarina, Poellinger, Lorenz
Publicado 2022

PKGIα is activated by metal-dependent oxidation in vitro but not in intact cells

por Aminzai, Sahar, Hu, Tingfei, Pilz, Renate B., Casteel, Darren E.
Publicado 2022

Identification of the riboflavin cofactor-binding site in the Vibrio cholerae ion-pumping NQR complex: A novel structural motif in redox enzymes

por Tuz, Karina, Yuan, Ming, Hu, Yuyao, Do, Tien T.T., Willow, Soohaeng Yoo, DePaolo-Boisvert, Joseph A., Fuller, James R., Minh, David D.L., Juárez, Oscar
Publicado 2022

Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40

por Mitchell, Joshua M., June, Cynthia M., Baggett, Vincent L., Lowe, Beth C., Ruble, James F., Bonomo, Robert A., Leonard, David A., Powers, Rachel A.
Publicado 2022

The association of lipids with amyloid fibrils

por Sanderson, John M.
Publicado 2022

Inhibition of MAP4K4 signaling initiates metabolic reprogramming to protect hepatocytes from lipotoxic damage

por Anand, Sumit Kumar, Caputo, Mara, Xia, Ying, Andersson, Emma, Cansby, Emmelie, Kumari, Sima, Henricsson, Marcus, Porosk, Rando, Keuenhof, Katharina Susanne, Höög, Johanna Louise, Nair, Syam, Marschall, Hanns-Ulrich, Blüher, Matthias, Mahlapuu, Margit
Publicado 2022

Insights into the structural dynamics and helicase-catalyzed unfolding of plant RNA G-quadruplexes

por Wang, Liu, Xu, Ya-Peng, Bai, Di, Shan, Song-Wang, Xie, Jie, Li, Yan, Wu, Wen-Qiang
Publicado 2022

Astrocyte ethanol exposure reveals persistent and defined calcium response subtypes and associated gene signatures

por Kim, Hyun-Bum, Lu, Youtao, Oh, Seonkyung C., Morris, Jacqueline, Miyashiro, Kevin, Kim, Junhyong, Eberwine, James, Sul, Jai-Yoon
Publicado 2022

Structural variations between small alarmone hydrolase dimers support different modes of regulation of the stringent response

por Bisiak, Francesco, Chrenková, Adriana, Zhang, Sheng-Da, Pedersen, Jannik N., Otzen, Daniel E., Zhang, Yong E., Brodersen, Ditlev E.
Publicado 2022

Structural biology of ex vivo mammalian prions

por Artikis, Efrosini, Kraus, Allison, Caughey, Byron
Publicado 2022

Structural basis for c-di-AMP–dependent regulation of the bacterial stringent response by receptor protein DarB

por Heidemann, Jana L., Neumann, Piotr, Krüger, Larissa, Wicke, Dennis, Vinhoven, Liza, Linden, Andreas, Dickmanns, Achim, Stülke, Jörg, Urlaub, Henning, Ficner, Ralf
Publicado 2022

MicroID2: A Novel Biotin Ligase Enables Rapid Proximity-Dependent Proteomics

por Johnson, Benjamin S., Chafin, Lexie, Farkas, Daniela, Adair, Jessica, Elhance, Ajit, Farkas, Laszlo, Bednash, Joseph S., Londino, James D.
Publicado 2022

Structural insights into the role of the WW2 domain on tandem WW–PPxY motif interactions of oxidoreductase WWOX

por Rotem-Bamberger, Shahar, Fahoum, Jamal, Keinan-Adamsky, Keren, Tsaban, Tomer, Avraham, Orly, Shalev, Deborah E., Chill, Jordan H., Schueler-Furman, Ora
Publicado 2022

A human IgE bispecific antibody shows potent cytotoxic capacity mediated by monocytes

por Vukovic, Natasa, Halabi, Samer, Russo-Cabrera, Joan Salvador, Blokhuis, Bart, Berraondo, Pedro, Redegeld, Frank A.M., Zaiss, Dietmar M.W.
Publicado 2022

Probe ultrasonification of egg yolk plasma forms low-density lipoprotein nanoparticles that efficiently protect canine semen during cryofreezing

por Anastácio da Silva, Edenara, Corcini, Carine Dahl, de Assis Araújo Camelo Junior, Francisco, Martins, Diego, Meneghello Gheller, Stela Mari, Hädrich, Gabriela, Dora, Cristiana Lima, Varela Junior, Antonio Sergio
Publicado 2022