Incorporation of fucose into glycans independent of the GDP-fucose transporter SLC35C1 preferentially utilizes salvaged over de novo GDP-fucose

por Skurska, Edyta, Szulc, Bożena, Maszczak-Seneczko, Dorota, Wiktor, Maciej, Wiertelak, Wojciech, Makowiecka, Aleksandra, Olczak, Mariusz
Publicado 2022

A new deep learning technique reveals the exclusive functional contributions of individual cancer mutations

por Gupta, Prashant, Jindal, Aashi, Ahuja, Gaurav, Jayadeva, Sengupta, Debarka
Publicado 2022

Mapping interactions between the CRAC activation domain and CC1 regulating the activity of the ER Ca(2+) sensor STIM1

por Shrestha, Nisha, Hye-Ryong Shim, Ann, Maneshi, Mohammad Mehdi, See-Wai Yeung, Priscilla, Yamashita, Megumi, Prakriya, Murali
Publicado 2022

Subcellular dynamics and functional activity of the cleaved intracellular domain of the Na(+) channel β1 subunit

por Haworth, Alexander S., Hodges, Samantha L., Capatina, Alina L., Isom, Lori L., Baumann, Christoph G., Brackenbury, William J.
Publicado 2022

Substoichiometric Hsp104 regulates the genesis and persistence of self-replicable amyloid seeds of Sup35 prion domain

por Mahapatra, Sayanta, Sarbahi, Anusha, Madhu, Priyanka, Swasthi, Hema M., Sharma, Abhishek, Singh, Priyanka, Mukhopadhyay, Samrat
Publicado 2022

Ceramide levels in blood plasma correlate with major depressive disorder severity and its neutralization abrogates depressive behavior in mice

por Schumacher, Fabian, Edwards, Michael J., Mühle, Christiane, Carpinteiro, Alexander, Wilson, Greg C., Wilker, Barbara, Soddemann, Matthias, Keitsch, Simone, Scherbaum, Norbert, Müller, Bernhard W., Lang, Undine E., Linnemann, Christoph, Kleuser, Burkhard, Müller, Christian P., Kornhuber, Johannes, Gulbins, Erich
Publicado 2022

Comparative Proteome and Cis-Regulatory Element Analysis Reveals Specific Molecular Pathways Conserved in Dog and Human Brains

por Hong, Huilin, Zhao, Zhiguang, Huang, Xiahe, Guo, Chao, Zhao, Hui, Wang, Guo-Dong, Zhang, Ya-Ping, Zhao, Jian-ping, Shi, Jianhui, Wu, Qing-Feng, Jiang, Yong-hui, Wang, Yingchun, Li, Lei M., Du, Zhuo, Zhang, Yong Q., Xiong, Ying
Publicado 2022

Copper inhibits protein maturation in the secretory pathway by targeting the Sec61 translocon in Saccharomyces cerevisiae

por Saha, Nitu, Tomar, Raghuvir Singh
Publicado 2022

Distinct basolateral amygdala excitatory inputs mediate the somatosensory and aversive-affective components of pain

por Meng, Xiaojing, Yue, Lingxiao, Liu, An, Tao, Wenjuan, Shi, Li, Zhao, Wan, Wu, Zhongmin, Zhang, Zhi, Wang, Liecheng, Zhang, Xulai, Zhou, Wenjie
Publicado 2022

Inhibition of lipid kinase PIKfyve reveals a role for phosphatase Inpp4b in the regulation of PI(3)P-mediated lysosome dynamics through VPS34 activity

por Saffi, Golam T., Wang, Cheng An, Mangialardi, Emily M., Vacher, Jean, Botelho, Roberto J., Salmena, Leonardo
Publicado 2022

Human testis–specific Y-encoded protein-like protein 5 is a histone H3/H4-specific chaperone that facilitates histone deposition in vitro

por Dalui, Sambit, Dasgupta, Anirban, Adhikari, Swagata, Das, Chandrima, Roy, Siddhartha
Publicado 2022

Nuclear protein quality control in yeast: The latest INQuiries

por Kumar, Arun, Mathew, Veena, Stirling, Peter C.
Publicado 2022

PvdM of fluorescent pseudomonads is required for the oxidation of ferribactin by PvdP in periplasmic pyoverdine maturation

por Sugue, Michael-Frederick, Burdur, Ali Nazmi, Ringel, Michael T., Dräger, Gerald, Brüser, Thomas
Publicado 2022

The small GTPase RAB10 regulates endosomal recycling of the LDL receptor and transferrin receptor in hepatocytes

por Khan, Taslima Gani, Ginsburg, David, Emmer, Brian T.
Publicado 2022

Differential expression patterns of phospholipase D isoforms 1 and 2 in the mammalian brain and retina

por Barber, Casey N., Goldschmidt, Hana L., Lilley, Brendan, Bygrave, Alexei M., Johnson, Richard C., Huganir, Richard L., Zack, Donald J., Raben, Daniel M.
Publicado 2022

Antibacterial peptide CyclomarinA creates toxicity by deregulating the Mycobacterium tuberculosis ClpC1–ClpP1P2 protease

por Taylor, Gabrielle, Frommherz, Yannick, Katikaridis, Panagiotis, Layer, Dominik, Sinning, Irmgard, Carroni, Marta, Weber-Ban, Eilika, Mogk, Axel
Publicado 2022

A peptoid-based inhibitor of protein arginine methyltransferase 1 (PRMT1) induces apoptosis and autophagy in cancer cells

por Brekker, Mollie A., Sartawi, Tala, Sawatzky, Tina M., Causey, Corey P., Rehman, Fatima Khwaja, Knuckley, Bryan
Publicado 2022

Seed-competent tau monomer initiates pathology in a tauopathy mouse model

por Mirbaha, Hilda, Chen, Dailu, Mullapudi, Vishruth, Terpack, Sandi Jo, White, Charles L., Joachimiak, Lukasz A., Diamond, Marc I.
Publicado 2022

Lipoate protein ligase B primarily recognizes the C(8)-phosphopantetheine arm of its donor substrate and weakly binds the acyl carrier protein

por Dhembla, Chetna, Yadav, Usha, Kundu, Suman, Sundd, Monica
Publicado 2022

Overexpression of MRX9 impairs processing of RNAs encoding mitochondrial oxidative phosphorylation factors COB and COX1 in yeast

por Chagas, Jhulia Almeida Clarck, Kfouri Martins Soares, Maria Antônia, Ribeiro Franco, Leticia Veloso, Barros, Mário H.
Publicado 2022