The PLEKHA7–PDZD11 complex regulates the localization of the calcium pump PMCA and calcium handling in cultured cells

por Sluysmans, Sophie, Salmaso, Andrea, Rouaud, Florian, Méan, Isabelle, Brini, Marisa, Citi, Sandra
Publicado 2022

Heterozygous p.Y955C mutation in DNA polymerase γ leads to alterations in bioenergetics, complex I subunit expression, and mtDNA replication

por Rahman, Md. Mostafijur, Young, Carolyn K.J., Goffart, Steffi, Pohjoismäki, Jaakko L.O., Young, Matthew J.
Publicado 2022

Evolutionary origin and functional diversification of aminotransferases

por Koper, Kaan, Han, Sang-Woo, Pastor, Delia Casas, Yoshikuni, Yasuo, Maeda, Hiroshi A.
Publicado 2022

FASN inhibitor TVB-3166 prevents S-acylation of the spike protein of human coronaviruses

por Mekhail, Katrina, Lee, Minhyoung, Sugiyama, Michael, Astori, Audrey, St-Germain, Jonathan, Latreille, Elyse, Khosraviani, Negar, Wei, Kuiru, Li, Zhijie, Rini, James, Lee, Warren L., Antonescu, Costin, Raught, Brian, Fairn, Gregory D.
Publicado 2022

Early Prediction of COVID-19 Patient Survival by Targeted Plasma Multi-Omics and Machine Learning

por Richard, Vincent R., Gaither, Claudia, Popp, Robert, Chaplygina, Daria, Brzhozovskiy, Alexander, Kononikhin, Alexey, Mohammed, Yassene, Zahedi, René P., Nikolaev, Evgeny N., Borchers, Christoph H.
Publicado 2022

Phosphorylation of SMURF2 by ATM exerts a negative feedback control of DNA damage response

por Tang, Liu-Ya, Thomas, Adam, Zhou, Ming, Zhang, Ying E.
Publicado 2021

Calcium and the Ca-ATPase SPCA1 modulate plasma membrane abundance of ZIP8 and ZIP14 to regulate Mn(II) uptake in brain microvascular endothelial cells

por Steimle, Brittany L., Bailey, Danielle K., Smith, Frances M., Rosenblum, Shaina L., Kosman, Daniel J.
Publicado 2022

Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox

por Xie, Jing, Robinson, Samuel D., Gilding, Edward K., Jami, Sina, Deuis, Jennifer R., Rehm, Fabian B.H., Yap, Kuok, Ragnarsson, Lotten, Chan, Lai Yue, Hamilton, Brett R., Harvey, Peta J., Craik, David J., Vetter, Irina, Durek, Thomas
Publicado 2022

The Casein kinase 1α agonist pyrvinium attenuates Wnt-mediated CK1α degradation via interaction with the E3 ubiquitin ligase component Cereblon

por Shen, Chen, Nayak, Anmada, Neitzel, Leif R., Yang, Fan, Li, Bin, Williams, Charles H., Hong, Charles C., Ahmed, Yashi, Lee, Ethan, Robbins, David J.
Publicado 2022

Energetic determinants of animal cell polarity regulator Par-3 interaction with the Par complex

por Penkert, Rhiannon R., Vargas, Elizabeth, Prehoda, Kenneth E.
Publicado 2022

Clathrin adaptor AP-1–mediated Golgi export of amyloid precursor protein is crucial for the production of neurotoxic amyloid fragments

por Januário, Yunan C., Eden, Jessica, de Oliveira, Luan S., De Pace, Raffaella, Tavares, Lucas A., da Silva-Januário, Mara E., Apolloni, Vinícius B., Wilby, Elise L., Altmeyer, Randolf, Burgos, Patricia V., Corrêa, Sonia A.L., Gershlick, David C., daSilva, Luis L.P.
Publicado 2022

Glycogen synthase kinase homolog Rim11 regulates lipid synthesis through the phosphorylation of Pah1 phosphatidate phosphatase in yeast

por Khondker, Shoily, Kwiatek, Joanna M., Han, Gil-Soo, Carman, George M.
Publicado 2022

Context-dependent pro- and anti-resection roles of ZKSCAN3 in the regulation of fork processing during replication stress

por Yang, Zheng, Lemacon, Delphine Sangotokun, Li, Shan, Cheruiyot, Abigael, Kong, Lingzhen, Tan, Ke, Cheng, Chen, Turkay, Ecenur, He, Dalin, You, Zhongsheng
Publicado 2022

Reduction of protein disulfide isomerase results in open conformations and stimulates dynamic exchange between structural ensembles

por Chinnaraj, Mathivanan, Flaumenhaft, Robert, Pozzi, Nicola
Publicado 2022

Bruton’s tyrosine kinase phosphorylates scaffolding and RNA-binding protein G3BP1 to induce stress granule aggregation during host sensing of foreign ribonucleic acids

por Kim, Susana S-Y., Sim, Don C.N., Carissimo, Guillaume, Lim, Hong-Hwa, Lam, Kong-Peng
Publicado 2022

Contribution of HIF-P4H isoenzyme inhibition to metabolism indicates major beneficial effects being conveyed by HIF-P4H-2 antagonism

por Tapio, Joona, Halmetoja, Riikka, Dimova, Elitsa Y., Mäki, Joni M., Laitala, Anu, Walkinshaw, Gail, Myllyharju, Johanna, Serpi, Raisa, Koivunen, Peppi
Publicado 2022

Oncogenic KRAS G12C: Kinetic and redox characterization of covalent inhibition

por Huynh, Minh V., Parsonage, Derek, Forshaw, Tom E., Chirasani, Venkat R., Hobbs, G. Aaron, Wu, Hanzhi, Lee, Jingyun, Furdui, Cristina M., Poole, Leslie B., Campbell, Sharon L.
Publicado 2022

Cell-intrinsic Wnt4 ligand regulates mitochondrial oxidative phosphorylation in macrophages

por Tlili, Mouna, Acevedo, Hamlet, Descoteaux, Albert, Germain, Marc, Heinonen, Krista M.
Publicado 2022

The conformational change of the protease inhibitor α(2)-macroglobulin is triggered by the retraction of the cleaved bait region from a central channel

por Harwood, Seandean Lykke, Diep, Khang, Nielsen, Nadia Sukusu, Jensen, Kathrine Tejlgård, Enghild, Jan J.
Publicado 2022

Selenoprotein TXNRD3 supports male fertility via the redox regulation of spermatogenesis

por Dou, Qianhui, Turanov, Anton A., Mariotti, Marco, Hwang, Jae Yeon, Wang, Huafeng, Lee, Sang-Goo, Paulo, Joao A., Yim, Sun Hee, Gygi, Stephen P., Chung, Jean-Ju, Gladyshev, Vadim N.
Publicado 2022