A WWP2–PTEN–KLF5 signaling axis regulates odontoblast differentiation and dentinogenesis in mice

por Fu, Jing, Zhang, Xiaobo, Zheng, Huiwen, Yang, Guobin, Chen, Zhi, Yuan, Guohua
Publicado 2022

Identification of cell type–specific correlations between ERK activity and cell viability upon treatment with ERK1/2 inhibitors

por Lebedev, Timofey D., Khabusheva, Elmira R., Mareeva, Sofia R., Ivanenko, Karina A., Morozov, Alexey V., Spirin, Pavel V., Rubtsov, Petr M., Snezhkina, Anastasiya V., Kudryavtseva, Anna V., Sorokin, Maxim I., Buzdin, Anton A., Prassolov, Vladimir S.
Publicado 2022

Metalloprotease ADAM9 cleaves ephrin-B ligands and differentially regulates Wnt and mTOR signaling downstream of Akt kinase in colorectal cancer cells

por Chandrasekera, Pathirennehelage, Perfetto, Mark, Lu, Congyu, Zhuo, Minghui, Bahudhanapati, Harinath, Li, Jiejing, Chen, Wei-Chih, Kulkarni, Pallavi, Christian, Laura, Liu, Jun, Yien, Yvette Y., Yu, Chundong, Wei, Shuo
Publicado 2022

Tissue transglutaminase activates integrin-linked kinase and β-catenin in ovarian cancer

por Condello, Salvatore, Prasad, Mayuri, Atwani, Rula, Matei, Daniela
Publicado 2022

Choline kinase inhibition promotes ER-phagy

por Tavasoli, Mahtab, Chipurupalli, Sandhya, McMaster, Christopher R.
Publicado 2022

In vitro single molecule and bulk phase studies reveal the AP-1 transcription factor cFos binds to DNA without its partner cJun

por Leech, James T., Brennan, Andrew, Don, Nicola A., Mason, Jody M., Kad, Neil M.
Publicado 2022

Modularity of the hydrophobic core and evolution of functional diversity in fold A glycosyltransferases

por Venkat, Aarya, Tehrani, Daniel, Taujale, Rahil, Yeung, Wayland, Gravel, Nathan, Moremen, Kelley W., Kannan, Natarajan
Publicado 2022

RNA induces unique tau strains and stabilizes Alzheimer’s disease seeds

por Zwierzchowski-Zarate, Amy N., Mendoza-Oliva, Aydé, Kashmer, Omar M., Collazo-Lopez, Josue E., White, Charles L., Diamond, Marc I.
Publicado 2022

Impaired mitophagy in Sanfilippo a mice causes hypertriglyceridemia and brown adipose tissue activation

por Tillo, Miguel, Lamanna, William C., Dwyer, Chrissa A., Sandoval, Daniel R., Pessentheiner, Ariane R., Al-Azzam, Norah, Sarrazin, Stéphane, Gonzales, Jon C., Kan, Shih-Hsin, Andreyev, Alexander Y., Schultheis, Nicholas, Thacker, Bryan E., Glass, Charles A., Dickson, Patricia I., Wang, Raymond Y., Selleck, Scott B., Esko, Jeffrey D., Gordts, Philip L.S.M.
Publicado 2022

A small molecule toll-like receptor antagonist rescues α-synuclein fibril pathology

por Chedid, Jessica, Labrador-Garrido, Adahir, Zhong, Siying, Gao, Jianqun, Zhao, Ye, Perera, Gayathri, Kim, Woojin S., Halliday, Glenda M., Dzamko, Nicolas
Publicado 2022

A UHM–ULM interface with unusual structural features contributes to U2AF2 and SF3B1 association for pre-mRNA splicing

por Galardi, Justin W., Bela, Victoria N., Jeffery, Nazish, He, Xueyang, Glasser, Eliezra, Loerch, Sarah, Jenkins, Jermaine L., Pulvino, Mary J., Boutz, Paul L., Kielkopf, Clara L.
Publicado 2022

Unraveling the toxic effects mediated by the neurodegenerative disease–associated S375G mutation of TDP-43 and its S375E phosphomimetic variant

por Paron, Francesca, Barattucci, Simone, Cappelli, Sara, Romano, Maurizio, Berlingieri, Christian, Stuani, Cristiana, Laurents, Douglas, Mompeán, Miguel, Buratti, Emanuele
Publicado 2022

A natural fusion of flavodiiron, rubredoxin, and rubredoxin oxidoreductase domains is a self-sufficient water-forming oxidase of Trichomonas vaginalis

por Abdulaziz, Evana N., Bell, Tristan A., Rashid, Bazlur, Heacock, Mina L., Begic, Tarik, Skinner, Owen S., Yaseen, Mohammad A., Chao, Luke H., Mootha, Vamsi K., Pierik, Antonio J., Cracan, Valentin
Publicado 2022

Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1

por Bandekar, Sumit J., Chen, Chun-Liang, Ravala, Sandeep K., Cash, Jennifer N., Avramova, Larisa V., Zhalnina, Mariya V., Gutkind, J. Silvio, Li, Sheng, Tesmer, John J.G.
Publicado 2022

The airway smooth muscle sodium/calcium exchanger NCLX is critical for airway remodeling and hyperresponsiveness in asthma

por Johnson, Martin T., Benson, J. Cory, Pathak, Trayambak, Xin, Ping, McKernan, Abagail S., Emrich, Scott M., Yoast, Ryan E., Walter, Vonn, Straub, Adam C., Trebak, Mohamed
Publicado 2022

Sulfotyrosine residues: Interaction specificity determinants for extracellular protein–protein interactions

por Stewart, Valley, Ronald, Pamela C.
Publicado 2022

Proximity-based labeling reveals DNA damage–induced phosphorylation of fused in sarcoma (FUS) causes distinct changes in the FUS protein interactome

por Johnson, Michelle A., Nuckols, Thomas A., Merino, Paola, Bagchi, Pritha, Nandy, Srijita, Root, Jessica, Taylor, Georgia, Seyfried, Nicholas T., Kukar, Thomas
Publicado 2022

Structural features of the protein kinase domain and targeted binding by small-molecule inhibitors

por Arter, Chris, Trask, Luke, Ward, Sarah, Yeoh, Sharon, Bayliss, Richard
Publicado 2022

A simple protocol for the production of highly deuterated proteins for biophysical studies

por Li, Jess, Byrd, R. Andrew
Publicado 2022

Individual and simultaneous treatment with antipsychotic aripiprazole and antidepressant trazodone inhibit sterol biosynthesis in the adult brain

por Balog, Marta, Anderson, Allison, Genaro-Mattos, Thiago C., Korade, Zeljka, Mirnics, Karoly
Publicado 2022