Single amino acids set apparent temperature thresholds for heat-evoked activation of mosquito transient receptor potential channel TRPA1

por Nguyen, Thi Hong Dung, Chapman, Stella, Kashio, Makiko, Saito, Claire, Strom, Tatjana, Yasui, Mio, Tominaga, Makoto
Publicado 2022

Activation of the canonical ER stress IRE1–XBP1 pathway by insulin regulates glucose and lipid metabolism

por Peng, Jinghua, Qin, Caolitao, Ramatchandirin, Balamurugan, Pearah, Alexia, Guo, Shaodong, Hussain, Mehboob, Yu, Liqing, Wondisford, Fredric E., He, Ling
Publicado 2022

Vitamin B3, nicotinamide, enhances mitochondrial metabolism to promote differentiation of the retinal pigment epithelium

por Hazim, Roni A., Paniagua, Antonio E., Tang, Lisa, Yang, Krista, Kim, Kristen K.O., Stiles, Linsey, Divakaruni, Ajit S., Williams, David S.
Publicado 2022

The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1)

por Farooq, Zeenat, Kusuma, Fedho, Burke, Phillip, Dufour, Catherine R., Lee, Duckgue, Tabatabaei, Negar, Toboz, Phoenix, Radovani, Ernest, Greenblatt, Jack F., Rehman, Jalees, Class, Jacob, Khoutorsky, Arkady, Fonseca, Bruno D., Richner, Justin M., Mercier, Eloi, Bourque, Guillaume, Giguère, Vincent, Subramaniam, Arvind R., Han, Jaeseok, Tahmasebi, Soroush
Publicado 2022

EPDR1 is a noncanonical effector of insulin-mediated angiogenesis regulated by an endothelial-specific TGF-β receptor complex

por Ahmed, Tasmia, Flores, Paola Cruz, Pan, Christopher C., Ortiz, Hannah R., Lee, Yeon S., Langlais, Paul R., Mythreye, Karthikeyan, Lee, Nam Y.
Publicado 2022

Mild membrane depolarization in neurons induces immediate early gene transcription and acutely subdues responses to a successive stimulus

por Rienecker, Kira D.A., Poston, Robert G., Segales, Joshua S., Finholm, Isabelle W., Sono, Morgan H., Munteanu, Sorina J., Ghaninejad-Esfahani, Mina, Rejepova, Ayna, Tejeda-Garibay, Susana, Wickman, Kevin, Marron Fernandez de Velasco, Ezequiel, Thayer, Stanley A., Saha, Ramendra N.
Publicado 2022

An antagonistic monoclonal anti–Plexin-B1 antibody exerts therapeutic effects in mouse models of postmenopausal osteoporosis and multiple sclerosis

por Vogler, Melanie, Oleksy, Arkadiusz, Schulze, Sabrina, Fedorova, Marina, Kojonazarov, Baktybek, Nijjar, Sharandip, Patel, Seema, Jossi, Sian, Sawmynaden, Kovilen, Henry, Maud, Brown, Richard, Matthews, David, Offermanns, Stefan, Worzfeld, Thomas
Publicado 2022

Molecular basis for variations in the sensitivity of pathogenic rhodopsin variants to 9-cis-retinal

por Roushar, Francis J., McKee, Andrew G., Kuntz, Charles P., Ortega, Joseph T., Penn, Wesley D., Woods, Hope, Chamness, Laura M., Most, Victoria, Meiler, Jens, Jastrzebska, Beata, Schlebach, Jonathan P.
Publicado 2022

Withdrawal: Pigment Epithelium-derived Factor Inhibits Angiogenesis via Regulated Intracellular Proteolysis of Vascular Endothelial Growth Factor Receptor 1

por Cai, Jun, Jiang, Wen G., Grant, Maria B., Boulton, Mike
Publicado 2022

Extended DNA-binding interfaces beyond the canonical SAP domain contribute to the function of replication stress regulator SDE2 at DNA replication forks

por Weinheimer, Alexandra S., Paung, YiTing, Rageul, Julie, Khan, Arafat, Lo, Natalie, Ho, Brian, Tong, Michael, Alphonse, Sébastien, Seeliger, Markus A., Kim, Hyungjin
Publicado 2022

Phosphorylation of mixed lineage kinase MLK3 by cyclin-dependent kinases CDK1 and CDK2 controls ovarian cancer cell division

por Cedeno-Rosario, Luis, Honda, David, Sunderland, Autumn M., Lewandowski, Mark D., Taylor, William R., Chadee, Deborah N.
Publicado 2022

Hepatic p53 is regulated by transcription factor FOXO1 and acutely controls glycogen homeostasis

por Oster, Moritz, Galhuber, Markus, Krstic, Jelena, Steinhoff, Julia S., Lenihan-Geels, Georgia, Wulff, Sascha, Kiefer, Marie F., Petricek, Konstantin M., Wowro, Sylvia J., Flores, Roberto E., Yang, Na, Li, Chen, Meng, Yueming, Reinisch, Isabel, Sommerfeld, Manuela, Weger, Stefan, Habisch, Hansjörg, Madl, Tobias, Schulz, Tim J., Prokesch, Andreas, Schupp, Michael
Publicado 2022

Skin fibroblast metabolomic profiling reveals that lipid dysfunction predicts the severity of Friedreich’s ataxia

por Wang, Dezhen, Ho, Elaine S., Cotticelli, M. Grazia, Xu, Peining, Napierala, Jill S., Hauser, Lauren A., Napierala, Marek, Himes, Blanca E., Wilson, Robert B., Lynch, David R., Mesaros, Clementina
Publicado 2022

Oncoprotein DJ-1 interacts with mTOR complexes to effect transcription factor Hif1α-dependent expression of collagen I (α2) during renal fibrosis

por Das, Falguni, Ghosh-Choudhury, Nandini, Maity, Soumya, Kasinath, Balakuntalam S., Choudhury, Goutam Ghosh
Publicado 2022

Implications of conformational flexibility, lipid binding, and regulatory domains in cell-traversal protein CelTOS for apicomplexan migration

por Kumar, Hirdesh, Jimah, John R., Misal, Santosh A., Salinas, Nichole D., Fried, Michal, Schlesinger, Paul H., Tolia, Niraj H.
Publicado 2022

Cyclin-dependent kinase 1 depolymerizes nuclear lamin filaments by disrupting the head-to-tail interaction of the lamin central rod domain

por Jeong, Soyeon, Ahn, Jinsook, Jo, Inseong, Kang, So-Mi, Park, Bum-Joon, Cho, Hyun-Soo, Kim, Yong-Hak, Ha, Nam-Chul
Publicado 2022

A new circular RNA–encoded protein BIRC6-236aa inhibits transmissible gastroenteritis virus (TGEV)–induced mitochondrial dysfunction

por Zhao, Xiaomin, Guo, Jianxiong, Wang, Xinyue, Lin, Jiadi, Liu, Zhihao, Xu, Chunmei, Zhang, Di, Tong, Dewen
Publicado 2022

Spectroscopic studies reveal details of substrate-induced conformational changes distant from the active site in isopenicillin N synthase

por Rabe, Patrick, Walla, Carla C., Goodyear, Noelle K., Welsh, Jordan, Southwart, Rebecca, Clifton, Ian, Linyard, James D.S., Tumber, Anthony, Claridge, Tim D.W., Myers, William K., Schofield, Christopher J.
Publicado 2022

A novel membrane targeting domain mediates the endosomal or Golgi localization specificity of small GTPases Rab22 and Rab31

por Banworth, Marcellus J., Liang, Zhimin, Li, Guangpu
Publicado 2022

CaMKII T286 phosphorylation has distinct essential functions in three forms of long-term plasticity

por Cook, Sarah G., Rumian, Nicole L., Bayer, K. Ulrich
Publicado 2022