Phytosphingosine ceramide mainly localizes in the central layer of the unique lamellar phase of skin lipid model systems

por Nădăban, Andreea, Gooris, Gerrit S., Beddoes, Charlotte M., Dalgliesh, Robert M., Bouwstra, Joke A.
Publicado 2022

Phosphoproteomic Analysis of FLCN Inactivation Highlights Differential Kinase Pathways and Regulatory TFEB Phosphoserines

por Glykofridis, Iris E., Henneman, Alex A., Balk, Jesper A., Goeij-de Haas, Richard, Westland, Denise, Piersma, Sander R., Knol, Jaco C., Pham, Thang V., Boekhout, Michiel, Zwartkruis, Fried J.T., Wolthuis, Rob M.F., Jimenez, Connie R.
Publicado 2022

Increasing access for biochemistry research in undergraduate education: The malate dehydrogenase CURE community

por Provost, Joseph J.
Publicado 2022

An immunogenic cell injury module for the single-cell multiplexed activity metabolomics platform to identify promising anti-cancer natural products

por Balsamo, Joseph A., Penton, Kathryn E., Zhao, Zhihan, Hayes, Madeline J., Lima, Sierra M., Irish, Jonathan M., Bachmann, Brian O.
Publicado 2022

Elevated de novo lipogenesis, slow liver triglyceride turnover, and clinical correlations in nonalcoholic steatohepatitis patients

por Lawitz, Eric J., Li, Kelvin W., Nyangau, Edna, Field, Tyler John, Chuang, Jen-Chieh, Billin, Andrew, Wang, Lulu, Wang, Ya, Huss, Ryan S., Chung, Chuhan, Subramanian, G. Mani, Myers, Robert P., Hellerstein, Marc K.
Publicado 2022

TatA and TatB generate a hydrophobic mismatch important for the function and assembly of the Tat translocon in Escherichia coli

por Mehner-Breitfeld, Denise, Ringel, Michael T., Tichy, Daniel Alexander, Endter, Laura J., Stroh, Kai Steffen, Lünsdorf, Heinrich, Risselada, Herre Jelger, Brüser, Thomas
Publicado 2022

Single mutations toggle the substrate selectivity of multifunctional Camptotheca secologanic acid synthases

por Miller, Justin C., Schuler, Mary A.
Publicado 2022

Plant-exclusive domain of trans-editing enzyme ProXp-ala confers dimerization and enhanced tRNA binding

por Byun, Jun-Kyu, Vu, John A., He, Siou-Luan, Jang, Jyan-Chyun, Musier-Forsyth, Karin
Publicado 2022

Unusual β1-4-galactosidase activity of an α1-6-mannosidase from Xanthomonas manihotis in the processing of branched hybrid and complex glycans

por She, Yi-Min, Klupt, Kody, Hatfield, Grayson, Jia, Zongchao, Tam, Roger Y.
Publicado 2022

Secretagogin is a Ca(2+)-dependent stress-responsive chaperone that may also play a role in aggregation-based proteinopathies

por Chidananda, Amrutha H., Khandelwal, Radhika, Jamkhindikar, Aditya, Pawar, Asmita D., Sharma, Anand K., Sharma, Yogendra
Publicado 2022

Mechanistic insights on novel small molecule allosteric activators of cGMP-dependent protein kinase PKG1α

por Tawa, Paul, Zhang, Lei, Metwally, Essam, Hou, Yan, McCoy, Mark A., Seganish, W. Michael, Zhang, Rumin, Frank, Emily, Sheth, Payal, Hanisak, Jennifer, Sondey, Christopher, Bauman, David, Soriano, Aileen
Publicado 2022

Protein arginine methyltransferase PRMT1 promotes adipogenesis by modulating transcription factors C/EBPβ and PPARγ

por Zhu, Qi, Wang, Dinghui, Liang, Feng, Tong, Xian, Liang, Ziyun, Wang, Xiaoyu, Chen, Yaosheng, Mo, Delin
Publicado 2022

The N-linker region of hERG1a upregulates hERG1b potassium channels

por Johnson, Ashley A., Crawford, Taylor R., Trudeau, Matthew C.
Publicado 2022

Bioinformatic prediction of putative conveyers of O-GlcNAc transferase intellectual disability

por Mitchell, Conor W., Czajewski, Ignacy, van Aalten, Daan M.F.
Publicado 2022

Butyrate inhibits IL-1β-induced inflammatory gene expression by suppression of NF-κB activity in pancreatic beta cells

por Pedersen, Signe Schultz, Prause, Michala, Williams, Kristine, Barrès, Romain, Billestrup, Nils
Publicado 2022

The SOS response-associated peptidase (SRAP) domain of YedK catalyzes ring opening of abasic sites and reversal of its DNA–protein cross-link

por Paulin, Katherine A., Cortez, David, Eichman, Brandt F.
Publicado 2022

The weaker-binding Fc γ receptor IIIa F158 allotype retains sensitivity to N-glycan composition and exhibits a destabilized antibody-binding interface

por Kremer, Paul G., Barb, Adam W.
Publicado 2022

A short amphipathic alpha helix in scavenger receptor BI facilitates bidirectional HDL-cholesterol transport

por May, Sarah C., Sahoo, Daisy
Publicado 2022

Meeting report: Flux-independent signaling by ionotropic receptors: Unforeseen roles, complexities, and challenges

por Montes de Oca Balderas, Pavel
Publicado 2022

Cleavage of mitochondrial homeostasis regulator PGAM5 by the intramembrane protease PARL is governed by transmembrane helix dynamics and oligomeric state

por Siebert, Verena, Silber, Mara, Heuten, Elena, Muhle-Goll, Claudia, Lemberg, Marius K.
Publicado 2022