Swapping N-terminal regions among tick evasins reveals cooperative interactions influencing chemokine binding and selectivity

por Aryal, Pramod, Devkota, Shankar Raj, Jeevarajah, Devadharshini, Law, Ruby, Payne, Richard J., Bhusal, Ram Prasad, Stone, Martin J.
Publicado 2022

Transcriptional regulator Taf14 binds DNA and is required for the function of transcription factor TFIID in the absence of histone H2A.Z

por Peil, Kadri, Värv, Signe, Ilves, Ivar, Kristjuhan, Kersti, Jürgens, Henel, Kristjuhan, Arnold
Publicado 2022

Chemically modified dsRNA induces RNAi effects in insects in vitro and in vivo: A potential new tool for improving RNA-based plant protection

por Howard, John D., Beghyn, Myriam, Dewulf, Nathalie, De Vos, Yves, Philips, Annelies, Portwood, David, Kilby, Peter M., Oliver, Duncan, Maddelein, Wendy, Brown, Stephen, Dickman, Mark J.
Publicado 2022

Reisomerization of retinal represents a molecular switch mediating Na(+) uptake and release by a bacterial sodium-pumping rhodopsin

por Fujisawa, Tomotsumi, Kinoue, Kouta, Seike, Ryouhei, Kikukawa, Takashi, Unno, Masashi
Publicado 2022

A newly identified flavoprotein disulfide reductase Har protects Streptococcus pneumoniae against hypothiocyanous acid

por Shearer, Heather L., Pace, Paul E., Paton, James C., Hampton, Mark B., Dickerhof, Nina
Publicado 2022

Dynamics of integrin α5β1, fibronectin, and their complex reveal sites of interaction and conformational change

por Su, Yang, Iacob, Roxana E., Li, Jing, Engen, John R., Springer, Timothy A.
Publicado 2022

Temporal and Sex-Linked Protein Expression Dynamics in a Familial Model of Alzheimer’s Disease

por Blasco Tavares Pereira Lopes, Filipa, Schlatzer, Daniela, Wang, Rihua, Li, Xiaolin, Feng, Emily, Koyutürk, Mehmet, Qi, Xin, Chance, Mark R.
Publicado 2022

Temperature-dependent hydrogen deuterium exchange shows impact of analog binding on adenosine deaminase flexibility but not embedded thermal networks

por Gao, Shuaihua, Zhang, Wenju, Barrow, Samuel L., Iavarone, Anthony T., Klinman, Judith P.
Publicado 2022

Human eukaryotic initiation factor 4E (eIF4E) and the nucleotide-bound state of eIF4A regulate eIF4F binding to RNA

por Izidoro, Mario Servulo, Sokabe, Masaaki, Villa, Nancy, Merrick, William C., Fraser, Christopher S.
Publicado 2022

SARS-CoV-2 hijacks macropinocytosis to facilitate its entry and promote viral spike–mediated cell-to-cell fusion

por Zhang, Yu-Yuan, Liang, Ronghui, Wang, Shu-Jie, Ye, Zi-Wei, Wang, Tong-Yun, Chen, Meng, Liu, Jianbo, Na, Lei, Yang, Yue-Lin, Yang, Yong-Bo, Yuan, Shuofeng, Yin, Xin, Cai, Xue-Hui, Tang, Yan-Dong
Publicado 2022

The Na(+),K(+)-ATPase in complex with beryllium fluoride mimics an ATPase phosphorylated state

por Fruergaard, Marlene U., Dach, Ingrid, Andersen, Jacob L., Ozol, Mette, Shahsavar, Azadeh, Quistgaard, Esben M., Poulsen, Hanne, Fedosova, Natalya U., Nissen, Poul
Publicado 2022

A novel Tetrahymena thermophila sterol C-22 desaturase belongs to the fatty acid hydroxylase/desaturase superfamily

por Sanchez Granel, María L., Siburu, Nicolás G., Fricska, Annamária, Maldonado, Lucas L., Gargiulo, Laura B., Nudel, Clara B., Uttaro, Antonio D., Nusblat, Alejandro D.
Publicado 2022

Interplay of carbon dioxide and peroxide metabolism in mammalian cells

por Radi, Rafael
Publicado 2022

Oxygen-dependent regulation of E3(SCF)ubiquitin ligases and a Skp1-associated JmjD6 homolog in development of the social amoeba Dictyostelium

por Boland, Andrew W., Gas-Pascual, Elisabet, Nottingham, Braxton L., van der Wel, Hanke, Daniel, Nitin G., Sheikh, M. Osman, Schafer, Christopher M., West, Christopher M.
Publicado 2022

Glycosylation of a key cubilin Asn residue results in reduced binding to albumin

por Yadav, Shiv Pratap Singh, Yu, Aiying, Zhao, Jingfu, Singh, Jasdeep, Kakkar, Saloni, Chakraborty, Srinivas, Mechref, Yehia, Molitoris, Bruce, Wagner, Mark C.
Publicado 2022

Phase-separation antagonists potently inhibit transcription and broadly increase nucleosome density

por Meduri, Rajyalakshmi, Rubio, Linda S., Mohajan, Suman, Gross, David S.
Publicado 2022

Proteasomal degradation of WT proinsulin in pancreatic beta cells

por Xu, Xiaoxi, Arunagiri, Anoop, Haataja, Leena, Alam, Maroof, Ji, Shuhui, Qi, Ling, Tsai, Billy, Liu, Ming, Arvan, Peter
Publicado 2022

Crystal structures of Schistosoma mansoni histone deacetylase 8 reveal a novel binding site for allosteric inhibitors

por Saccoccia, Fulvio, Pozzetti, Luca, Gimmelli, Roberto, Butini, Stefania, Guidi, Alessandra, Papoff, Giuliana, Giannaccari, Marialaura, Brogi, Simone, Scognamiglio, Viviana, Gemma, Sandra, Ruberti, Giovina, Campiani, Giuseppe
Publicado 2022

An evolutionary divergent thermodynamic brake in ZAP-70 fine-tunes the kinetic proofreading in T cells

por Gangopadhyay, Kaustav, Roy, Arnab, Chandradasan, Athira C., Roy, Swarnendu, Debnath, Olivia, SenGupta, Soumee, Chowdhury, Subhankar, Das, Dipjyoti, Das, Rahul
Publicado 2022

Quantitative Proteomics Identifies Proteins Enriched in Large and Small Extracellular Vesicles

por Lischnig, Anna, Bergqvist, Markus, Ochiya, Takahiro, Lässer, Cecilia
Publicado 2022