Histone deacetylase-10 liberates spermidine to support polyamine homeostasis and tumor cell growth

por Stewart, Tracy Murray, Foley, Jackson R., Holbert, Cassandra E., Klinke, Glynis, Poschet, Gernot, Steimbach, Raphael R., Miller, Aubry K., Casero, Robert A.
Publicado 2022

Hyperactivation of the proteasome in Caenorhabditis elegans protects against proteotoxic stress and extends lifespan

por Anderson, Raymond T., Bradley, Thomas A., Smith, David M.
Publicado 2022

Structural basis for the dual catalytic activity of the Legionella pneumophila ovarian tumor (OTU) domain deubiquitinase LotA

por Luo, Jiwei, Ruan, Xinglin, Huang, Zhijie, Li, Zekai, Ye, Le, Wu, Yongyu, Zhen, Xiangkai, Ouyang, Songying
Publicado 2022

Discovery of an ʟ-amino acid ligase implicated in Staphylococcal sulfur amino acid metabolism

por Pederick, Jordan L., Horsfall, Aimee J., Jovcevski‬, Blagojce, Klose, Jack, Abell, Andrew D., Pukala, Tara L., Bruning, John B.
Publicado 2022

The histone deacetylases Rpd3 and Hst1 antagonistically regulate de novo NAD(+) metabolism in the budding yeast Saccharomyces cerevisiae

por Groth, Benjamin, Huang, Chi-Chun, Lin, Su-Ju
Publicado 2022

Unexpected structures formed by the kinase RET C634R mutant extracellular domain suggest potential oncogenic mechanisms in MEN2A

por Liu, Yixin, De Castro Ribeiro, Orquidea, Haapanen, Outi, Craven, Gregory B., Sharma, Vivek, Muench, Stephen P., Goldman, Adrian
Publicado 2022

Mechanistic insight into the RNA-stimulated ATPase activity of tick-borne encephalitis virus helicase

por Anindita, Paulina Duhita, Halbeisen, Marco, Řeha, David, Tuma, Roman, Franta, Zdenek
Publicado 2022

Impaired Cdc20 signaling promotes senescence in normal cells and apoptosis in non–small cell lung cancer cells

por Volonte, Daniela, Sedorovitz, Morgan, Galbiati, Ferruccio
Publicado 2022

Inositol acylation of phosphatidylinositol mannosides: a rapid mass response to membrane fluidization in mycobacteria

por Nguyen, Peter P., Kado, Takehiro, Prithviraj, Malavika, Siegrist, M. Sloan, Morita, Yasu S.
Publicado 2022

Paradoxical activation of transcription factor SREBP1c and de novo lipogenesis by hepatocyte-selective ATP-citrate lyase depletion in obese mice

por Yenilmez, Batuhan, Kelly, Mark, Zhang, Guo-Fang, Wetoska, Nicole, Ilkayeva, Olga R., Min, Kyounghee, Rowland, Leslie, DiMarzio, Chloe, He, Wentao, Raymond, Naideline, Lifshitz, Lawrence, Pan, Meixia, Han, Xianlin, Xie, Jun, Friedline, Randall H., Kim, Jason K., Gao, Guangping, Herman, Mark A., Newgard, Christopher B., Czech, Michael P.
Publicado 2022

Host cell membrane proteins located near SARS-CoV-2 spike protein attachment sites are identified using proximity labeling and proteomic analysis

por Kotani, Norihiro, Nakano, Takanari, Kuwahara, Ryusuke
Publicado 2022

Acute retinol mobilization by retinol-binding protein 4 in mouse liver induces fibroblast growth factor 21 expression

por Steinhoff, Julia S., Wagner, Carina, Taschler, Ulrike, Wulff, Sascha, Kiefer, Marie F., Petricek, Konstantin M., Wowro, Sylvia J., Oster, Moritz, Flores, Roberto E., Yang, Na, Li, Chen, Meng, Yueming, Sommerfeld, Manuela, Weger, Stefan, Henze, Andrea, Raila, Jens, Lass, Achim, Schupp, Michael
Publicado 2022

Fluorescent detection of hydrogen sulfide (H(2)S) through the formation of pyrene excimers enhances H(2)S quantification in biochemical systems

por Pose, Manuela, Dillon, Kearsley M., Denicola, Ana, Alvarez, Beatriz, Matson, John B., Möller, Matías N., Cuevasanta, Ernesto
Publicado 2022

N-glycosylation modulates enzymatic activity of Trypanosoma congolense trans-sialidase

por Rosenau, Jana, Grothaus, Isabell Louise, Yang, Yikun, Kumar, Nilima Dinesh, Ciacchi, Lucio Colombi, Kelm, Sørge, Waespy, Mario
Publicado 2022

An ELISA-based platform for rapid identification of structure-dependent nucleic acid–protein interactions detects novel DNA triplex interactors

por Economos, Nicholas G., Thapar, Upasna, Balasubramanian, Nanda, Karras, Georgios I., Glazer, Peter M.
Publicado 2022

Quantitative interactome proteomics identifies a proteostasis network for GABA(A) receptors

por Wang, Ya-Juan, Di, Xiao-Jing, Mu, Ting-Wei
Publicado 2022

Proto-oncogene FAM83A contributes to casein kinase 1–mediated mitochondrial maintenance and white adipocyte differentiation

por Huang, Kuilong, Jia, Zhihao, Li, Haoran, Peng, Ying, Chen, Xiaochang, Luo, Nanjian, Song, Tongxing, Wang, Yingqian, Shi, Xin’e, Kuang, Shihuan, Yang, Gongshe
Publicado 2022

Plasma proteoforms of apolipoproteins C-I and C-II are associated with plasma lipids in the Multi-Ethnic Study of Atherosclerosis

por Koska, Juraj, Furtado, Jeremy, Hu, Yueming, Sinari, Shripad, Budoff, Matthew J., Billheimer, Dean, Nedelkov, Dobrin, McClelland, Robyn L., Reaven, Peter D.
Publicado 2022

Functional Diversity and Evolution of the Drosophila Sperm Proteome

por Garlovsky, Martin D., Sandler, Jessica A., Karr, Timothy L.
Publicado 2022

Serum dihydroceramides correlate with insulin sensitivity in humans and decrease insulin sensitivity in vitro

por Zarini, Simona, Brozinick, Joseph T., Zemski Berry, Karin A., Garfield, Amanda, Perreault, Leigh, Kerege, Anna, Bui, Hai Hoang, Sanders, Phil, Siddall, Parker, Kuo, Ming Shang, Bergman, Bryan C.
Publicado 2022