Obesity reprograms the pulmonary polyunsaturated fatty acid-derived lipidome, transcriptome, and gene-oxylipin networks

por Virk, Rafia, Buddenbaum, Nicole, Al-Shaer, Abrar, Armstrong, Michael, Manke, Jonathan, Reisdorph, Nichole, Sergin, Selin, Fenton, Jenifer I., Wallace, E. Diane, Ehrmann, Brandie M., Lovins, Hannah B., Gowdy, Kymberly M., Smith, M Ryan, Smith, Gregory J., Kelada, Samir N.P., Shaikh, Saame Raza
Publicado 2022

The conformations and basal conformational dynamics of translocation factor SecDF vary with translocon SecYEG interaction

por Weaver, D.R., Amin, D.N., King, G.M.
Publicado 2022

Oxidation of two cysteines within yeast Hsp70 impairs proteostasis while directly triggering an Hsf1-dependent cytoprotective response

por Santiago, Alec, Morano, Kevin A.
Publicado 2022

Tied up in knots: Untangling substrate recognition by the SPOUT methyltransferases

por Strassler, Sarah E., Bowles, Isobel E., Dey, Debayan, Jackman, Jane E., Conn, Graeme L.
Publicado 2022

Isoform a4 of the vacuolar ATPase a subunit promotes 4T1-12B breast cancer cell–dependent tumor growth and metastasis in vivo

por Su, Kevin, Collins, Michael P., McGuire, Christina M., Alshagawi, Mohammed A., Alamoudi, Mariam K., Li, Zhen, Forgac, Michael
Publicado 2022

The transcription factor Cdx2 regulates inflammasome activity through expression of the NLRP3 suppressor TRIM31 to maintain intestinal homeostasis

por Jahan, Sanzida, Awaja, Nidaa, Hess, Bradley, Hajjar, Stephanie, Sad, Subash, Lohnes, David
Publicado 2022

Peristaltic pumps adapted for laminar flow experiments enhance in vitro modeling of vascular cell behavior

por Abello, Javier, Raghavan, Shreya, Yien, Yvette Y., Stratman, Amber N.
Publicado 2022

The efficacy of receptor tyrosine kinase EphA2 autophosphorylation increases with EphA2 oligomer size

por Zapata-Mercado, Elmer, Biener, Gabriel, McKenzie, Daniel M., Wimley, William C., Pasquale, Elena B., Raicu, Valerica, Hristova, Kalina
Publicado 2022

PrkA is an ATP-dependent protease that regulates sporulation in Bacillus subtilis

por Zhang, Ao, Lebrun, Régine, Espinosa, Leon, Galinier, Anne, Pompeo, Frédérique
Publicado 2022

A shared, stochastic pathway mediates exosome protein budding along plasma and endosome membranes

por Fordjour, Francis K., Guo, Chenxu, Ai, Yiwei, Daaboul, George G., Gould, Stephen J.
Publicado 2022

Hedgehog acyltransferase catalyzes a random sequential reaction and utilizes multiple fatty acyl-CoA substrates

por Schonbrun, Adina R., Resh, Marilyn D.
Publicado 2022

A bona fide MAP kinase

por Oldach, Laurel
Publicado 2022

Functional characterization of two variants of mitochondrial topoisomerase TOP1MT that impact regulation of the mitochondrial genome

por Al Khatib, Iman, Deng, Jingti, Symes, Andrew, Kerr, Marina, Zhang, Hongliang, Huang, Shar-yin Naomi, Pommier, Yves, Khan, Aneal, Shutt, Timothy E.
Publicado 2022

The acyclotide ribe 31 from Rinorea bengalensis has selective cytotoxicity and potent insecticidal properties in Drosophila

por Dang, Tien T., Huang, Yen-Hua, Ott, Stanislav, Harvey, Peta J., Gilding, Edward K., Tombling, Benjamin J., Chan, Lai Y., Kaas, Quentin, Claridge-Chang, Adam, Craik, David J.
Publicado 2022

Peptide OM-LV20 protects astrocytes against oxidative stress via the ‘PAC1R/JNK/TPH1’ axis

por Yin, Saige, Pang, Ailan, Liu, Chengxing, Li, Yilin, Liu, Naixin, Li, Shanshan, Li, Chao, Sun, Huilin, Fu, Zhe, Wang, Yinglei, Zhang, Yue, Yang, Meifeng, Sun, Jun, Wang, Ying, Yang, Xinwang
Publicado 2022

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1

por Luciano, Amelia K., Korobkina, Ekaterina D., Lyons, Scott P., Haley, John A., Fluharty, Shelagh M., Jung, Su Myung, Kettenbach, Arminja N., Guertin, David A.
Publicado 2022

Met/Val129 polymorphism of the full-length human prion protein dictates distinct pathways of amyloid formation

por Pauly, Thomas, Bolakhrif, Najoua, Kaiser, Jesko, Nagel-Steger, Luitgard, Gremer, Lothar, Gohlke, Holger, Willbold, Dieter
Publicado 2022

ATP-binding cassette protein ABCA7 deficiency impairs sphingomyelin synthesis, cognitive discrimination, and synaptic plasticity in the entorhinal cortex

por Iqbal, Jahangir, Suarez, Manuel D., Yadav, Pradeep K., Walsh, Meghan T., Li, Yimeng, Wu, Yiyang, Huang, Zhengwei, James, Antonisamy William, Escobar, Victor, Mokbe, Ashwag, Brickman, Adam M., Luchsinger, José A., Dai, Kezhi, Moreno, Herman, Hussain, M. Mahmood
Publicado 2022

A previously uncharacterized O-glycopeptidase from Akkermansia muciniphila requires the Tn-antigen for cleavage of the peptide bond

por Medley, Brendon J., Leclaire, Leif, Thompson, Nicole, Mahoney, Keira E., Pluvinage, Benjamin, Parson, Matthew A.H., Burke, John E., Malaker, Stacy, Wakarchuk, Warren, Boraston, Alisdair B.
Publicado 2022

The RNA-binding protein AUF1 facilitates Akt phosphorylation at the membrane

por Li, Mei-Ling, Ragupathi, Aparna, Patel, Nikhil, Hernandez, Tatiana, Magsino, Jedrick, Werlen, Guy, Brewer, Gary, Jacinto, Estela
Publicado 2022