Protein arginine methyltransferase 5 is essential for oncogene product EWSR1-ATF1-mediated gene transcription in clear cell sarcoma

por Li, Bingbing X., David, Larry L., Davis, Lara E., Xiao, Xiangshu
Publicado 2022

Whole cell response to receptor stimulation involves many deep and distributed subcellular biochemical processes

por Hansen, Jens, Siddiq, Mustafa M., Yadaw, Arjun Singh, Tolentino, Rosa E., Rabinovich, Vera, Jayaraman, Gomathi, Jain, Mohit Raja, Liu, Tong, Li, Hong, Xiong, Yuguang, Goldfarb, Joseph, Iyengar, Ravi
Publicado 2022

Alkaline-sensitive two-pore domain potassium channels form functional heteromers in pancreatic β-cells

por Khoubza, Lamyaa, Gilbert, Nicolas, Kim, Eun-Jin, Chatelain, Franck C., Feliciangeli, Sylvain, Abelanet, Sophie, Kang, Dawon, Lesage, Florian, Bichet, Delphine
Publicado 2022

Densely methylated DNA traps Methyl-CpG–binding domain protein 2 but permits free diffusion by Methyl-CpG–binding domain protein 3

por Leighton, Gage O., Irvin, Elizabeth Marie, Kaur, Parminder, Liu, Ming, You, Changjiang, Bhattaram, Dhruv, Piehler, Jacob, Riehn, Robert, Wang, Hong, Pan, Hai, Williams, David C.
Publicado 2022

Identification of lysophosphatidic acid in serum as a factor that promotes epithelial apical junctional complex organization

por Sakakibara, Shotaro, Sakane, Ayuko, Sasaki, Takuya, Shinohara, Masakazu, Maruo, Tomohiko, Miyata, Muneaki, Mizutani, Kiyohito, Takai, Yoshimi
Publicado 2022

ER entry pathway and glycosylation of GPI-anchored proteins are determined by N-terminal signal sequence and C-terminal GPI-attachment sequence

por Hirata, Tetsuya, Yang, Jing, Tomida, Seita, Tokoro, Yuko, Kinoshita, Taroh, Fujita, Morihisa, Kizuka, Yasuhiko
Publicado 2022

Metabolomics reveals inosine 5′-monophosphate is increased during mice adipocyte browning

por Takahashi, Haruya, Tokura, Motohiro, Kawarasaki, Satoko, Nagai, Hiroyuki, Iwase, Mari, Nishitani, Kento, Okaze, Haruka, Mohri, Shinsuke, Ito, Tetsuro, Ara, Takeshi, Jheng, Huei-Fen, Nomura, Wataru, Kawada, Teruo, Inoue, Kazuo, Goto, Tsuyoshi
Publicado 2022

Glu289 residue in the pore-forming motif of Vibrio cholerae cytolysin is important for efficient β-barrel pore formation

por Mondal, Anish Kumar, Sengupta, Nayanika, Singh, Mahendra, Biswas, Rupam, Lata, Kusum, Lahiri, Indrajit, Dutta, Somnath, Chattopadhyay, Kausik
Publicado 2022

Structures of Streptococcus pyogenes class A sortase in complex with substrate and product mimics provide key details of target recognition

por Johnson, D. Alex, Piper, Isabel M., Vogel, Brandon A., Jackson, Sophie N., Svendsen, Justin E., Kodama, Hanna M., Lee, Darren E., Lindblom, Katy M., McCarty, James, Antos, John M., Amacher, Jeanine F.
Publicado 2022

The heme-regulated inhibitor kinase requires dimerization for heme-sensing activity

por Ricketts, M. Daniel, Emptage, Ryan P., Blobel, Gerd A., Marmorstein, Ronen
Publicado 2022

Specific phosphorylation of microtubule-associated protein 2c by extracellular signal–regulated kinase reduces interactions at its Pro-rich regions

por Plucarová, Jitka, Jansen, Séverine, Narasimhan, Subhash, Laníková, Alice, Lewitzky, Marc, Feller, Stephan M., Žídek, Lukáš
Publicado 2022

Mass Spectrometry Identification of Biomarkers in Extracellular Vesicles From Plasmodium vivax Liver Hypnozoite Infections

por Gualdrón-López, Melisa, Díaz-Varela, Miriam, Zanghi, Gigliola, Aparici-Herraiz, Iris, Steel, Ryan W.J., Schäfer, Carola, Cuscó, Pol, Chuenchob, Vorada, Kangwangransan, Niwat, Billman, Zachary P., Olsen, Tayla M., González, Juan R., Roobsoong, Wanlapa, Sattabongkot, Jetsumon, Murphy, Sean C., Mikolajczak, Sebastian A., Borràs, Eva, Sabidó, Eduard, Fernandez-Becerra, Carmen, Flannery, Erika L., Kappe, Stefan H.I., del Portillo, Hernando A.
Publicado 2022

Pyrvinium doubles against WNT-driven cancer

por Fan, Jiaming, Reid, Russell R., He, Tong-Chuan
Publicado 2022

AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans

por Wizrah, Maha S.I., Chua, Sheena M.H., Luo, Zhenyao, Manik, Mohammad K., Pan, Mengqi, Whyte, Jessica M.L., Robertson, Avril A.B., Kappler, Ulrike, Kobe, Bostjan, Fraser, James A.
Publicado 2022

α-Crystallin chaperone mimetic drugs inhibit lens γ-crystallin aggregation: Potential role for cataract prevention

por Islam, Sidra, Do, Michael T., Frank, Brett S., Hom, Grant L., Wheeler, Samuel, Fujioka, Hisashi, Wang, Benlian, Minocha, Geeta, Sell, David R., Fan, Xingjun, Lampi, Kirsten J., Monnier, Vincent M.
Publicado 2022

Engineering functional thermostable proteins using ancestral sequence reconstruction

por Thomson, Raine E.S., Carrera-Pacheco, Saskya E., Gillam, Elizabeth M.J.
Publicado 2022

Multi-OMICs analysis reveals metabolic and epigenetic changes associated with macrophage polarization

por Sowers, Mark L., Tang, Hui, Singh, Vipul K., Khan, Arshad, Mishra, Abhishek, Restrepo, Blanca I., Jagannath, Chinnaswamy, Zhang, Kangling
Publicado 2022

Multiomic Analysis Reveals Disruption of Cholesterol Homeostasis by Cannabidiol in Human Cell Lines

por Guard, Steven E., Chapnick, Douglas A., Poss, Zachary C., Ebmeier, Christopher C., Jacobsen, Jeremy, Nemkov, Travis, Ball, Kerri A., Webb, Kristofor J., Simpson, Helen L., Coleman, Stephen, Bunker, Eric, Ramirez, Adrian, Reisz, Julie A., Sievers, Robert, Stowell, Michael H.B., D’Alessandro, Angelo, Liu, Xuedong, Old, William M.
Publicado 2022

PCSK9 is minimally associated with HDL but impairs the anti-atherosclerotic HDL effects on endothelial cell activation

por Dafnis, Ioannis, Tsouka, Aikaterini N., Gkolfinopoulou, Christina, Tellis, Constantinos C., Chroni, Angeliki, Tselepis, Alexandros D.
Publicado 2022

G protein–coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin

por Varney, Matthew J., Steyaert, Wouter, Coucke, Paul J., Delanghe, Joris R., Uehling, David E., Joseph, Babu, Marcellus, Richard, Al-awar, Rima, Benovic, Jeffrey L.
Publicado 2022