BTK kinase activity is dispensable for the survival of diffuse large B-cell lymphoma

por Yuan, Hongwei, Zhu, Yutong, Cheng, Yalong, Hou, Junjie, Jin, Fengjiao, Li, Menglin, Jia, Wei, Cheng, Zhenzhen, Xing, Haimei, Liu, Mike, Han, Ting
Publicado 2022

Integrated proteomics identifies PARP inhibitor-induced prosurvival signaling changes as potential vulnerabilities in ovarian cancer

por Deng, Ou, Dash, Sweta, Nepomuceno, Thales C., Fang, Bin, Yun, Sang Y., Welsh, Eric A., Lawrence, Harshani R., Marchion, Douglas, Koomen, John M., Monteiro, Alvaro N., Rix, Uwe
Publicado 2022

Improved mammalian retromer cryo-EM structures reveal a new assembly interface

por Kendall, Amy K., Chandra, Mintu, Xie, Boyang, Wan, William, Jackson, Lauren P.
Publicado 2022

Lactic acid bacteria–derived γ-linolenic acid metabolites are PPARδ ligands that reduce lipid accumulation in human intestinal organoids

por Noguchi, Makoto, Shimizu, Makoto, Lu, Peng, Takahashi, Yu, Yamauchi, Yoshio, Sato, Shintaro, Kiyono, Hiroshi, Kishino, Shigenobu, Ogawa, Jun, Nagata, Koji, Sato, Ryuichiro
Publicado 2022

Glycosyltransferases EXTL2 and EXTL3 cellular balance dictates heparan sulfate biosynthesis and shapes gastric cancer cell motility and invasion

por Marques, Catarina, Poças, Juliana, Gomes, Catarina, Faria-Ramos, Isabel, Reis, Celso A., Vivès, Romain R., Magalhães, Ana
Publicado 2022

α-synuclein buildup is alleviated via ESCRT-dependent endosomal degradation brought about by p38MAPK inhibition in cells expressing p25α

por Borland, Helena, Rasmussen, Izabela, Bjerregaard-Andersen, Kaare, Rasmussen, Michel, Olsen, Anders, Vilhardt, Frederik
Publicado 2022

Artificial pore blocker acts specifically on voltage-gated potassium channel isoform K(V)1.6

por Gigolaev, Andrei M., Lushpa, Vladislav A., Pinheiro-Junior, Ernesto L., Tabakmakher, Valentin M., Peigneur, Steve, Ignatova, Anastasija A., Feofanov, Alexey V., Efremov, Roman G., Mineev, Konstantin S., Tytgat, Jan, Vassilevski, Alexander A.
Publicado 2022

Regulation of factor V by the anticoagulant protease activated protein C: Influence of the B-domain and TFPIα

por Ayombil, Francis, Petrillo, Teodolinda, Kim, Haein, Camire, Rodney M.
Publicado 2022

Rapid genomic changes by mineralotropic hormones and kinase SIK inhibition drive coordinated renal Cyp27b1 and Cyp24a1 expression via CREB modules

por Meyer, Mark B., Benkusky, Nancy A., Lee, Seong Min, Yoon, Sung-Hee, Mannstadt, Michael, Wein, Marc N., Pike, J. Wesley
Publicado 2022

“Disruption of the molecular clock severely affects lipid metabolism in a hepatocellular carcinoma cell model”

por Monjes, Natalia M., Wagner, Paula M., Guido, Mario E.
Publicado 2022

Bacterial conversion of a host weapon into a nutritional signal

por Valvano, Miguel A.
Publicado 2022

Aurora A–mediated pyruvate kinase M2 phosphorylation promotes biosynthesis with glycolytic metabolites and tumor cell cycle progression

por Jiang, Ya, Wang, Ting, Sheng, Dandan, Han, Chaoqiang, Xu, Tian, Zhang, Peng, You, Weiyi, Fan, Weiwei, Zhang, Zhiyong, Jin, Tengchuan, Duan, Xiaotao, Yuan, Xiao, Liu, Xing, Zhang, Kaiguang, Ruan, Ke, Shi, Jue, Guo, Jing, Cheng, Aoxing, Yang, Zhenye
Publicado 2022

Tracking the Stability of Clinically Relevant Blood Plasma Proteins with Delta-S-Cys-Albumin—A Dilute-and-Shoot LC/MS-Based Marker of Specimen Exposure to Thawed Conditions

por Kapuruge, Erandi P., Jehanathan, Nilojan, Rogers, Stephen P., Williams, Stacy, Chung, Yunro, Borges, Chad R.
Publicado 2022

Inositol phosphorylceramide synthase null Leishmania are viable and virulent in animal infections where salvage of host sphingomyelin predominates

por Kuhlmann, F. Matthew, Key, Phillip N., Hickerson, Suzanne M., Turk, John, Hsu, Fong-Fu, Beverley, Stephen M.
Publicado 2022

Outer surface lipoproteins from the Lyme disease spirochete exploit the molecular switch mechanism of the complement protease C1s

por Garrigues, Ryan J., Thomas, Sheila, Leong, John M., Garcia, Brandon L.
Publicado 2022

Isocitrate binds to the itaconic acid–responsive LysR-type transcriptional regulator RipR in Salmonella pathogenesis

por Ki, Nayeon, Kim, Jinshil, Jo, Inseong, Hyun, Yongseong, Ryu, Sangryeol, Ha, Nam-Chul
Publicado 2022

Anti-CRISPR protein AcrIF4 inhibits the type I-F CRISPR-Cas surveillance complex by blocking nuclease recruitment and DNA cleavage

por Gao, Zhengyu, Zhang, Laixing, Ge, Zihao, Wang, Hao, Yue, Yourun, Jiang, Zhuobing, Wang, Xin, Xu, Chenying, Zhang, Yi, Yang, Maojun, Feng, Yue
Publicado 2022

Quantitative Phosphoproteomics Analysis Uncovers PAK2- and CDK1-Mediated Malignant Signaling Pathways in Clear Cell Renal Cell Carcinoma

por Senturk, Aydanur, Sahin, Ayse T., Armutlu, Ayse, Kiremit, Murat Can, Acar, Omer, Erdem, Selcuk, Bagbudar, Sidar, Esen, Tarik, Ozlu, Nurhan
Publicado 2022

The role of FXR and TGR5 in reversing and preventing progression of Western diet–induced hepatic steatosis, inflammation, and fibrosis in mice

por Wang, Xiaoxin X., Xie, Cen, Libby, Andrew E., Ranjit, Suman, Levi, Jonathan, Myakala, Komuraiah, Bhasin, Kanchan, Jones, Bryce A., Orlicky, David J., Takahashi, Shogo, Dvornikov, Alexander, Kleiner, David E., Hewitt, Stephen M., Adorini, Luciano, Kopp, Jeffrey B., Krausz, Kristopher W., Rosenberg, Avi, McManaman, James L., Robertson, Charles E., Ir, Diana, Frank, Daniel N., Luo, Yuhuan, Gonzalez, Frank J., Gratton, Enrico, Levi, Moshe
Publicado 2022

Insights into the biochemical and biophysical mechanisms mediating the longevity of the transparent optics of the eye lens

por Quinlan, Roy A., Clark, John I.
Publicado 2022