Metal migration and subunit swapping in ALS-linked SOD1: Zn(2+) transfer between mutant and wild-type occurs faster than the rate of heterodimerization

por Dashnaw, Chad M., Zhang, Ao Yun, Gonzalez, Mayte, Koone, Jordan C., Shaw, Bryan F.
Publicado 2022

Glucose-6-phosphate dehydrogenase exerts antistress effects independently of its enzymatic activity

por Jin, Xiaohan, Li, Xuexue, Li, Lifang, Zhong, Benfu, Hong, Yang, Niu, Jing, Li, Binghui
Publicado 2022

Redox properties and PAS domain structure of the Escherichia coli energy sensor Aer indicate a multistate sensing mechanism

por Maschmann, Zachary A., Chua, Teck Khiang, Chandrasekaran, Siddarth, Ibáñez, Héctor, Crane, Brian R.
Publicado 2022

A cell-based chemical-genetic screen for amino acid stress response inhibitors reveals torins reverse stress kinase GCN2 signaling

por Brüggenthies, Johanna B., Fiore, Alessandra, Russier, Marion, Bitsina, Christina, Brötzmann, Julian, Kordes, Susanne, Menninger, Sascha, Wolf, Alexander, Conti, Elena, Eickhoff, Jan E., Murray, Peter J.
Publicado 2022

In vitro transdifferentiated signatures of goat preadipocytes into mammary epithelial cells revealed by DNA methylation and transcriptome profiling

por Yan, Xiao-Ru, Shi, Tao, Xiao, Jia-Ying, Liu, Ya-Fang, Zheng, Hui-Ling
Publicado 2022

Herpes simplex virus 1 protein pUL21 alters ceramide metabolism by activating the interorganelle transport protein CERT

por Benedyk, Tomasz H., Connor, Viv, Caroe, Eve R., Shamin, Maria, Svergun, Dmitri I., Deane, Janet E., Jeffries, Cy M., Crump, Colin M., Graham, Stephen C.
Publicado 2022

Angiotensin-converting enzyme 2 improves hepatic insulin resistance by regulating GABAergic signaling in the liver

por Chen, Qi, Gao, Yuanyuan, Yang, Fengying, Deng, Hongjun, Wang, Ying, Yuan, Li
Publicado 2022

Mechanism of chorismate dehydratase MqnA, the first enzyme of the futalosine pathway, proceeds via substrate-assisted catalysis

por Prasad, Archna, Breithaupt, Constanze, Nguyen, Duc-Anh, Lilie, Hauke, Ziegler, Jörg, Stubbs, Milton T.
Publicado 2022

Structural studies of SALL family protein zinc finger cluster domains in complex with DNA reveal preferential binding to an AATA tetranucleotide motif

por Ru, Wenwen, Koga, Tomoyuki, Wang, Xiaoyang, Guo, Qiong, Gearhart, Micah D., Zhao, Shidong, Murphy, Mark, Kawakami, Hiroko, Corcoran, Dylan, Zhang, Jiahai, Zhu, Zhongliang, Yao, Xuebiao, Kawakami, Yasuhiko, Xu, Chao
Publicado 2022

N-glycosylation of mannose receptor (CD206) regulates glycan binding by C-type lectin domains

por Stavenhagen, Kathrin, Mehta, Akul Y., Laan, Lisa, Gao, Chao, Heimburg-Molinaro, Jamie, van Die, Irma, Cummings, Richard D.
Publicado 2022

Control of cell surface expression of GABA(A) receptors by a conserved region at the end of the N-terminal extracellular domain of receptor subunits

por Yuan, Banghao, Hatchett-Walker, Caroline, Long, Philip, Xu, Zhihan, Stephenson, F Anne, Haider, Shozeb, Jovanovic, Jasmina N.
Publicado 2022

A mutated glycosaminoglycan-binding domain functions as a novel probe to selectively target heparin-like epitopes on tumor cells

por Xu, Yingying, Shi, Liran, Qin, Yong, Yuan, Xunyi, Wang, Xu, Zhang, Qingdong, Wei, Lin, Du, Min, Liu, Yi, Yuan, Min, Xu, Xiangyu, Cheng, Ruiqing, Zou, Ruyi, Wang, Wenshuang, Li, Fuchuan
Publicado 2022

NanoSIMS imaging of lipid absorption by intestinal enterocytes

por Chen, Kai, Song, Wenxin, Russell, Robert, Ferrari, Alessandra, Darwish, Tamim, Tontonoz, Peter, Young, Stephen G., Jiang, Haibo
Publicado 2022

Adipose Tissue, Bile Acids, and Gut Microbiome Species Associated With Gallstones After Bariatric Surgery

por Guman, M.S.S., Hoozemans, J.B., Haal, S., de Jonge, P.A., Aydin, Ö., Lappa, D., Meijnikman, A.S., Westerink, F., Acherman, Y., Bäckhed, F., de Brauw, M., Nielsen, J., Nieuwdorp, M., Groen, A.K., Gerdes, V.E.A.
Publicado 2022

Scaffold proteins as dynamic integrators of biological processes

por DiRusso, Christopher J., Dashtiahangar, Maryam, Gilmore, Thomas D.
Publicado 2022

Cancer-associated Notch receptor variants lead to O-fucosylation defects that deregulate Notch signaling

por Pennarubia, Florian, Ito, Atsuko, Takeuchi, Megumi, Haltiwanger, Robert S.
Publicado 2022

Endothelial Acid Sphingomyelinase Promotes NLRP3 Inflammasome and Neointima Formation During Hypercholesterolemia

por Yuan, Xinxu, Bhat, Owais M., Zou, Yao, Li, Xiang, Zhang, Yang, Li, Pin-Lan
Publicado 2022

The extracellular domain of site-2-metalloprotease RseP is important for sensitivity to bacteriocin EntK1

por Kristensen, Sofie S., Oftedal, Thomas F., Røhr, Åsmund K., Eijsink, Vincent G.H., Mathiesen, Geir, Diep, Dzung B.
Publicado 2022

Disentangling autoproteolytic cleavage from tethered agonist–dependent activation of the adhesion receptor ADGRL3

por Perry-Hauser, Nicole A., VanDyck, Max W., Lee, Kuo Hao, Shi, Lei, Javitch, Jonathan A.
Publicado 2022

In-Depth Characterization of the Clostridioides difficile Phosphoproteome to Identify Ser/Thr Kinase Substrates

por Garcia-Garcia, Transito, Douché, Thibaut, Giai Gianetto, Quentin, Poncet, Sandrine, El Omrani, Nesrine, Smits, Wiep Klaas, Cuenot, Elodie, Matondo, Mariette, Martin-Verstraete, Isabelle
Publicado 2022