Regio-Specific N-Glycome and N-Glycoproteome Map of the Elderly Human Brain With and Without Alzheimer’s Disease

por Tena, Jennyfer, Maezawa, Izumi, Barboza, Mariana, Wong, Maurice, Zhu, Chenghao, Alvarez, Michael Russelle, Jin, Lee-Way, Zivkovic, Angela M., Lebrilla, Carlito B.
Publicado 2022

Targeting dendritic cells with TLR-2 ligand–coated nanoparticles loaded with Mycobacterium tuberculosis epitope induce antituberculosis immunity

por Kumar Das, Deepjyoti, Zafar, Mohammad Adeel, Nanda, Sidhanta, Singh, Sanpreet, Lamba, Taruna, Bashir, Hilal, Singh, Pargat, Maurya, Sudeep Kumar, Nadeem, Sajid, Sehrawat, Sharvan, Bhalla, Vijayender, Agrewala, Javed Naim
Publicado 2022

A novel site on dual-specificity phosphatase MKP7/DUSP16 is required for catalysis and MAPK binding

por Shillingford, Shanelle, Zhang, Lei, Surovtseva, Yulia, Dorry, Sam, Lolis, Elias, Bennett, Anton M.
Publicado 2022

Crystal structure of the collagen prolyl 4-hydroxylase (C-P4H) catalytic domain complexed with PDI: Toward a model of the C-P4H α(2)β(2) tetramer

por Murthy, Abhinandan V., Sulu, Ramita, Lebedev, Andrey, Salo, Antti M., Korhonen, Kati, Venkatesan, Rajaram, Tu, Hongmin, Bergmann, Ulrich, Jänis, Janne, Laitaoja, Mikko, Ruddock, Lloyd W., Myllyharju, Johanna, Koski, M. Kristian, Wierenga, Rik K.
Publicado 2022

Three-dimensional structure of a mycobacterial oligoribonuclease reveals a unique C-terminal tail that stabilizes the homodimer

por Badhwar, Pooja, Khan, Sabab Hasan, Taneja, Bhupesh
Publicado 2022

Nanobody derived using a peptide epitope from the spike protein receptor-binding motif inhibits entry of SARS-CoV-2 variants

por Mendon, Nivya, Ganie, Rayees A., Kesarwani, Shubham, Dileep, Drisya, Sasi, Sarika, Lama, Prakash, Chandra, Anchal, Sirajuddin, Minhajuddin
Publicado 2022

Accessing isotopically labeled proteins containing genetically encoded phosphoserine for NMR with optimized expression conditions

por Vesely, Cat Hoang, Reardon, Patrick N., Yu, Zhen, Barbar, Elisar, Mehl, Ryan A., Cooley, Richard B.
Publicado 2022

A higher plant FAD synthetase is fused to an inactivated FAD pyrophosphatase

por Lynch, Joseph H., Roje, Sanja
Publicado 2022

A bovine antibody possessing an ultralong complementarity-determining region CDRH3 targets a highly conserved epitope in sarbecovirus spike proteins

por Burke, Matthew J., Scott, James N.F., Minshull, Thomas C., Gao, Zeqian, Manfield, Iain, Savic, Sinisa, Stockley, Peter G., Calabrese, Antonio N., Boyes, Joan
Publicado 2022

G protein gamma subunit, a hidden master regulator of GPCR signaling

por Kankanamge, Dinesh, Tennakoon, Mithila, Karunarathne, Ajith, Gautam, N.
Publicado 2022

High Sensitivity and Wide Linearity LC-MS/MS Method for Oxylipin Quantification in Multiple Biological Samples

por Fu, Xian, Yin, Hou-Hua, Wu, Ming-Jun, He, Xin, Jiang, Qing, Zhang, Ling-Tong, Liu, Jun-Yan
Publicado 2022

Baat Gene Knockout Alters Post-Natal Development, the Gut Microbiome, and Reveals Unusual Bile Acids in Mice

por Neugebauer, Kerri A., Okros, Maxwell, Guzior, Douglas V., Feiner, Jeremiah, Chargo, Nicholas J., Rzepka, Madison, Schilmiller, Anthony L., O’Reilly, Sandra, Jones, A. Daniel, Watson, Victoria E., Luyendyk, James P., McCabe, Laura R., Quinn, Robert A.
Publicado 2022

Intrinsically disordered plant protein PARCL colocalizes with RNA in phase-separated condensates whose formation can be regulated by mutating the PLD

por Ostendorp, Anna, Ostendorp, Steffen, Zhou, Yuan, Chaudron, Zoé, Wolffram, Lukas, Rombi, Khadija, von Pein, Linn, Falke, Sven, Jeffries, Cy M., Svergun, Dmitri I., Betzel, Christian, Morris, Richard J., Kragler, Friedrich, Kehr, Julia
Publicado 2022

Dennd5b-Deficient Mice are Resistant to PCSK9-Induced Hypercholesterolemia and Diet-Induced Hepatic Steatosis

por Mobilia, Maura, Whitus, Callie, Karakashian, Alexander, Lu, Hong S., Daugherty, Alan, Gordon, Scott M.
Publicado 2022

Heat shock protein Hspa13 regulates endoplasmic reticulum and cytosolic proteostasis through modulation of protein translocation

por Espinoza, Mateo F., Nguyen, Khanh K., Sycks, Melody M., Lyu, Ziqi, Quanrud, Guy M., Montoya, Maureen R., Genereux, Joseph C.
Publicado 2022

A CACNA1C variant associated with cardiac arrhythmias provides mechanistic insights in the calmodulation of L-type Ca(2+) channels

por Zhao, Juan, Segura, Emilie, Marsolais, Mireille, Parent, Lucie
Publicado 2022

Biophysical insights into glucose-dependent transcriptional regulation by PDX1

por Usher, Emery T., Showalter, Scott A.
Publicado 2022

Long noncoding RNA HOTAIR regulates the stemness of breast cancer cells via activation of the NF-κB signaling pathway

por Wang, Jiajia, Liu, Xingzhu, Li, Ping, Wang, Junrong, Shu, Yu, Zhong, Xinyu, Gao, Zhen, Yang, Jingyi, Jiang, Yashuang, Zhou, Xile, Yang, Geng
Publicado 2022

Grk7 but not Grk1 undergoes cAMP-dependent phosphorylation in zebrafish cone photoreceptors and mediates cone photoresponse recovery to elevated cAMP

por Chrispell, Jared D., Xiong, Yubin, Weiss, Ellen R.
Publicado 2022

Analysis of Plasmodium falciparum myosin B ATPase activity and structure in complex with the calmodulin-like domain of its light chain MLC-B

por Pires, Isa, Hung, Yu-Fu, Bergmann, Ulrich, Molloy, Justin E., Kursula, Inari
Publicado 2022