Methyltransferase SMYD3 impairs hypoxia tolerance by augmenting hypoxia signaling independent of its enzymatic activity

por Wang, Zixuan, Chen, Xiaoyun, Fan, Sijia, Zhu, Chunchun, Deng, Hongyan, Tang, Jinhua, Sun, Xueyi, Jia, Shuke, Liao, Qian, Xiao, Wuhan, Liu, Xing
Publicado 2022

Analysis of apoB Concentrations Across Early Adulthood and Predictors for Rates of Change Using CARDIA Study Data

por Wilkins, John T., Ning, Hongyan, Sniderman, Allan, Stone, Neil, Otvos, James, Jacobs, David R., Shah, Ravi, Murthy, Venkatesh L., Rana, Jamal, Allen, Norrina, Lloyd-Jones, Donald M.
Publicado 2022

A lysine residue from an extracellular turret switches the ion preference in a Cav3 T-Type channel from calcium to sodium ions

por Guan, Wendy, Orellana, Kaidy G., Stephens, Robert F., Zhorov, Boris S., Spafford, J. David
Publicado 2022

Requirement of hepatic pyruvate carboxylase during fasting, high fat, and ketogenic diet

por Selen, Ebru S., Rodriguez, Susana, Cavagnini, Kyle S., Kim, Han-Byeol, Na, Chan Hyun, Wolfgang, Michael J.
Publicado 2022

A novel connection between Trypanosoma brucei mitochondrial proteins TbTim17 and TbTRAP1 is discovered using Biotinylation Identification (BioID)

por Soto-Gonzalez, Fidel, Tripathi, Anuj, Cooley, Ayorinde, Paromov, Victor, Rana, Tanu, Chaudhuri, Minu
Publicado 2022

Long noncoding RNA SNHG5 promotes podocyte injury via the microRNA-26a-5p/TRPC6 pathway in diabetic nephropathy

por Zhou, Yan, Li, Zuo-Lin, Ding, Lin, Zhang, Xing-Jian, Liu, Nan-Chi, Liu, Shan-Shan, Wang, Yan-Fei, Ma, Rui-Xia
Publicado 2022

Sequential hydrolysis of FAD by ecto-5′ nucleotidase CD73 and alkaline phosphatase is required for uptake of vitamin B(2) into cells

por Shichinohe, Natsuki, Kobayashi, Daisuke, Izumi, Ayaka, Hatanaka, Kazuya, Fujita, Rio, Kinoshita, Taroh, Inoue, Norimitsu, Hamaue, Naoya, Wada, Keiji, Murakami, Yoshiko
Publicado 2022

Stress response protein REDD1 promotes diabetes-induced retinal inflammation by sustaining canonical NF-κB signaling

por Sunilkumar, Siddharth, Toro, Allyson L., McCurry, Christopher M., VanCleave, Ashley M., Stevens, Shaunaci A., Miller, William P., Kimball, Scot R., Dennis, Michael D.
Publicado 2022

Anionic lipid vesicles have differential effects on the aggregation of early onset-associated α-synuclein missense mutants

por Watt, Kathryn J.C., Meade, Richard M., Williams, Robert J., Mason, Jody M.
Publicado 2022

TFEB acetylation promotes lysosome biogenesis and ameliorates Alzheimer’s disease–relevant phenotypes in mice

por Li, Tianyou, Yin, Limin, Kang, Xinyi, Xue, Wenlong, Wang, Ning, Zhang, Jie, Yuan, Ping, Lin, Lingxi, Li, Yang
Publicado 2022

Intracerebroventricular dosing of N-sulfoglucosamine sulfohydrolase in mucopolysaccharidosis IIIA mice reduces markers of brain lysosomal dysfunction

por Magat, Jenna, Jones, Samantha, Baridon, Brian, Agrawal, Vishal, Wong, Hio, Giaramita, Alexander, Mangini, Linley, Handyside, Britta, Vitelli, Catherine, Parker, Monica, Yeung, Natasha, Zhou, Yu, Pungor, Erno, Slabodkin, Ilya, Gorostiza, Olivia, Aguilera, Allora, Lo, Melanie J., Alcozie, Saida, Christianson, Terri M., Tiger, Pascale M.N., Vincelette, Jon, Fong, Sylvia, Gil, Geuncheol, Hague, Chuck, Lawrence, Roger, Wendt, Daniel J., Lebowitz, Jonathan H., Bunting, Stuart, Bullens, Sherry, Crawford, Brett E., Roy, Sushmita M., Woloszynek, Josh C.
Publicado 2022

Amyloid beta and its naturally occurring N-terminal variants are potent activators of human and mouse formyl peptide receptor 1

por Busch, Lukas, al Taleb, Zukaa, Tsai, Yu-Liang, Nguyen, Vu Thu Thuy, Lu, Qi, Synatschke, Christopher V., Endres, Kristina, Bufe, Bernd
Publicado 2022

Intracellular pathogen Leishmania intervenes in iron loading into ferritin by cleaving chaperones in host macrophages as an iron acquisition strategy

por Sen, Sandhya, Bal, Saswat Kumar, Yadav, Sameeksha, Mishra, Pragya, G, Vishnu Vivek, Rastogi, Ruchir, Mukhopadhyay, Chinmay K.
Publicado 2022

The kringle IV type 2 domain variant 4925G>A causes the elusive association signal of the LPA pentanucleotide repeat

por Grüneis, Rebecca, Weissensteiner, Hansi, Lamina, Claudia, Schönherr, Sebastian, Forer, Lukas, Di Maio, Silvia, Streiter, Gertraud, Peters, Annette, Gieger, Christian, Kronenberg, Florian, Coassin, Stefan
Publicado 2022

Androgen receptor suppresses β-adrenoceptor-mediated CREB activation and thermogenesis in brown adipose tissue of male mice

por Harada, Naoki, Kubo, Keitaro, Onishi, Teruaki, Kitakaze, Tomoya, Goto, Tsuyoshi, Inui, Hiroshi, Yamaji, Ryoichi
Publicado 2022

Inflammasome sensor NLRP1 disease variant M1184V promotes autoproteolysis and DPP9 complex formation by stabilizing the FIIND domain

por Moecking, Jonas, Laohamonthonkul, Pawat, Meşe, Kubilay, Hagelueken, Gregor, Steiner, Annemarie, Harapas, Cassandra R., Sandow, Jarrod J., Graves, Jonathan D., Masters, Seth L., Geyer, Matthias
Publicado 2022

A method for the isolation and characterization of autophagic bodies from yeast provides a key tool to investigate cargos of autophagy

por Kawamata, Tomoko, Makino, Shiho, Kagohashi, Yoko, Sasaki, Michiko, Ohsumi, Yoshinori
Publicado 2022

The Second Asia-Oceania Human Proteome Organization (AOHUPO) Online Education Series on the Renaissance of Clinical Proteomics: Biomarkers, Imaging and Therapeutics

por Low, Teck Yew, Chen, Yu-Ju, Ishihama, Yasushi, Chung, Max Ching Ming, Cordwell, Stuart, Poon, Terence Chuen Wai, Kwon, Ho Jeong
Publicado 2022

Correction: The ARSACS disease protein sacsin controls lysosomal positioning and reformation by regulating microtubule dynamics

por Francis, Vincent, Alshafie, Walaa, Kumar, Rahul, Girard, Martine, Brais, Bernard, McPherson, Peter S.
Publicado 2022

The noncatalytic regions of the tyrosine kinase Tnk1 are important for activity and substrate specificity

por Ahmed, Sultan, Miller, W. Todd
Publicado 2022