The Non Catalytic Protein ERG28 has a Functional Role in Cholesterol Synthesis and is Coregulated Transcriptionally

por Capell-Hattam, Isabelle M., Fenton, Nicole M., Coates, Hudson W., Sharpe, Laura J., Brown, Andrew J.
Publicado 2022

Spirodalesol analog 8A inhibits NLRP3 inflammasome activation and attenuates inflammatory disease by directly targeting adaptor protein ASC

por Liu, Wen, Yang, Jiashu, Fang, Shihao, Jiao, Chenyang, Gao, Jianhua, Zhang, Aihua, Wu, Tiancong, Tan, Renxiang, Xu, Qiang, Guo, Wenjie
Publicado 2022

Glucagon-like peptide-1 analog liraglutide leads to multiple metabolic alterations in diet-induced obese mice

por Park, Seokjae, Oh, Sungjoon, Kim, Eun-Kyoung
Publicado 2022

Mediterranean G6PD variant mitigates expression of DNA methyltransferases and right heart pressure in experimental model of pulmonary hypertension

por Jacob, Christina, Kitagawa, Atsushi, Signoretti, Christina, Dzieciatkowska, Monika, D’Alessandro, Angelo, Gupte, Aaditya, Hossain, Shakib, D’Addario, Catherine A., Gupte, Rakhee, Gupte, Sachin A.
Publicado 2022

Enhancing interaction of actin and actin-binding domain 1 of dystrophin with modulators: Toward improved gene therapy for Duchenne muscular dystrophy

por Guhathakurta, Piyali, Carter, Anna L., Thompson, Andrew R., Kurila, Dillon, LaFrence, Jeffrey, Zhang, Li, Trask, Jake R., Vanderheyden, Bri, Muretta, Joseph M., Ervasti, James M., Thomas, David D.
Publicado 2022

Export of polybasic motif–containing secretory proteins BMP8A and SFRP1 from the endoplasmic reticulum is regulated by surfeit locus protein 4

por Tang, Xiao, Wang, Tingxuan, Guo, Yusong
Publicado 2022

Long-range allostery mediates the regulation of plasminogen activator inhibitor-1 by cell adhesion factor vitronectin

por Kihn, Kyle, Marchiori, Elisa, Spagnolli, Giovanni, Boldrini, Alberto, Terruzzi, Luca, Lawrence, Daniel A., Gershenson, Anne, Faccioli, Pietro, Wintrode, Patrick L.
Publicado 2022

Src-mediated phosphorylation of the ribosome biogenesis factor hYVH1 affects its localization, promoting partitioning to the 60S ribosomal subunit

por DaDalt, Ashley A., Bonham, Christopher A., Lotze, Griffin P., Luiso, Adrian A., Vacratsis, Panayiotis O.
Publicado 2022

A comprehensive set of ER protein disulfide isomerase family members supports the biogenesis of proinflammatory interleukin 12 family cytokines

por Mideksa, Yonatan G., Aschenbrenner, Isabel, Fux, Anja, Kaylani, Dinah, Weiß, Caroline A.M., Nguyen, Tuan-Anh, Bach, Nina C., Lang, Kathrin, Sieber, Stephan A., Feige, Matthias J.
Publicado 2022

Gambogic acid and juglone inhibit RNase P through distinct mechanisms

por Wu Meyers, Nancy, Karasik, Agnes, Kaitany, Kipchumba, Fierke, Carol A., Koutmos, Markos
Publicado 2022

Structures of a constitutively active mutant of human IDH3 reveal new insights into the mechanisms of allosteric activation and the catalytic reaction

por Chen, Xingchen, Sun, Pengkai, Liu, Yan, Shen, Senlin, Ma, Tengfei, Ding, Jianping
Publicado 2022

pH profiles of 3-chymotrypsin-like protease (3CLpro) from SARS-CoV-2 elucidate its catalytic mechanism and a histidine residue critical for activity

por Al Adem, Kenana, Ferreira, Juliana C., Fadl, Samar, Rabeh, Wael M.
Publicado 2022

Flow cytometric reporter assays provide robust functional analysis of signaling complexes

por Muusse, Timothy W., Lee, Morris Y.L., Kim, Hyoyoung, Parat, Marie-Odile, Nanson, Jeffrey D., Kobe, Bostjan, Vajjhala, Parimala R., Stacey, Katryn J.
Publicado 2022

The E3 ligase subunit FBXO45 binds the interferon-λ receptor and promotes its degradation during influenza virus infection

por Tsai, MuChun, Osman, Wissam, Adair, Jessica, ElMergawy, Rabab, Chafin, Lexie, Johns, Finny, Farkas, Daniela, Elhance, Ajit, Londino, James, Mallampalli, Rama K.
Publicado 2022

ABCA1 and cholesterol transfer protein Aster-A promote an asymmetric cholesterol distribution in the plasma membrane

por Ogasawara, Fumihiko, Ueda, Kazumitsu
Publicado 2022

Structural studies of human fission protein FIS1 reveal a dynamic region important for GTPase DRP1 recruitment and mitochondrial fission

por Egner, John M., Nolden, Kelsey A., Harwig, Megan Cleland, Bonate, Ryan P., De Anda, Jaime, Tessmer, Maxx H., Noey, Elizabeth L., Ihenacho, Ugochukwu K., Liu, Ziwen, Peterson, Francis C., Wong, Gerard C.L., Widlansky, Michael E., Hill, R. Blake
Publicado 2022

Glucagon changes substrate preference in gluconeogenesis

por Xu, Huiting, Wang, Yujue, Kwon, Hyokjoon, Shah, Ankit, Kalemba, Katarzyna, Su, Xiaoyang, He, Ling, Wondisford, Fredric E.
Publicado 2022

Identification of Novel Kinases of Tau Using Fluorescence Complementation Mass Spectrometry (FCMS)

por Kao, Der-Shyang, Du, Yanyan, DeMarco, Andrew G., Min, Sehong, Hall, Mark C., Rochet, Jean-Christophe, Tao, W. Andy
Publicado 2022

Activin receptor ALK4 promotes adipose tissue hyperplasia by suppressing differentiation of adipocyte precursors

por Lee, Ee-Soo, Guo, Tingqing, Srivastava, Raj Kamal, Shabbir, Assim, Ibáñez, Carlos F.
Publicado 2022

GLUT1 is a highly efficient L-fucose transporter

por Ng, Bobby G., Sosicka, Paulina, Xia, Zhijie, Freeze, Hudson H.
Publicado 2022