Transcription factor SOX15 regulates stem cell pluripotency and promotes neural fate during differentiation by activating the neurogenic gene Hes5

por Choi, Eun-Bee, Vodnala, Munender, Saini, Prince, Anugula, Sharath, Zerbato, Madeleine, Ho, Jaclyn J., Wang, Jianing, Ho Sui, Shannan J., Yoon, Joon, Roels, Marielle, Inouye, Carla, Fong, Yick W.
Publicado 2023

A new electrochemical method that mimics phosphorylation of the core tau peptide K18 enables kinetic and structural analysis of intermediates and assembly

por Masquelier, Eloise, Taxon, Esther, Liang, Sheng-Ping, Al Sabeh, Yahya, Sepunaru, Lior, Gordon, Michael J., Morse, Daniel E.
Publicado 2023

Innate immune cell-intrinsic ketogenesis is dispensable for organismal metabolism and age-related inflammation

por Goldberg, Emily L., Letian, Anudari, Dlugos, Tamara, Leveau, Claire, Dixit, Vishwa Deep
Publicado 2023

chi sequences switch the RecBCD helicase–nuclease complex from degradative to replicative modes during the completion of DNA replication

por Hamilton, Nicklas A., Jehru, Avery E., Samples, William N., Wendel, Brian M., Mokhtari, Parisa D., Courcelle, Charmain T., Courcelle, Justin
Publicado 2023

Uncovering Zn(2+) as a cofactor of FAD-dependent Pseudomonas aeruginosa PAO1 d-2-hydroxyglutarate dehydrogenase

por Quaye, Joanna A., Gadda, Giovanni
Publicado 2023

p38 MAPK and MKP-1 control the glycolytic program via the bifunctional glycolysis regulator PFKFB3 during sepsis

por Mager, Carli E., Mormol, Justin M., Shelton, Evan D., Murphy, Parker R., Bowman, Bridget A., Barley, Timothy J., Wang, Xiantao, Linn, Sarah C., Liu, Kevin, Nelin, Leif D., Hafner, Markus, Liu, Yusen
Publicado 2023

Multi–Cell Line Analysis of Lysosomal Proteomes Reveals Unique Features and Novel Lysosomal Proteins

por Akter, Fatema, Bonini, Sara, Ponnaiyan, Srigayatri, Kögler-Mohrbacher, Bianca, Bleibaum, Florian, Damme, Markus, Renard, Bernhard Y., Winter, Dominic
Publicado 2023

Comprehensive Proteomics Analysis Identifies CD38-Mediated NAD(+) Decline Orchestrating Renal Fibrosis in Pediatric Patients With Obstructive Nephropathy

por Tao, Yuandong, Wang, Jifeng, Lyu, Xuexue, Li, Na, Lai, Dong, Liu, Yuanyuan, Zhang, Xingyue, Li, Pin, Cao, Shouqing, Zhou, Xiaoguang, Zhao, Yang, Ma, Lifei, Tao, Tian, Feng, Zhichun, Li, Xiubin, Yang, Fuquan, Zhou, Huixia
Publicado 2023

A short-chain acyl-CoA synthetase that supports branched-chain fatty acid synthesis in Staphylococcus aureus

por Whaley, Sarah G., Frank, Matthew W., Rock, Charles O.
Publicado 2023

Disordered proteins mitigate the temperature dependence of site-specific binding free energies

por Thole, Joseph F., Waudby, Christopher A., Pielak, Gary J.
Publicado 2023

Comprehensive mass spectrometry lipidomics of human biofluids and ocular tissues

por Vasku, Glenda, Peltier, Caroline, He, Zhiguo, Thuret, Gilles, Gain, Philippe, Gabrielle, Pierre-Henry, Acar, Niyazi, Berdeaux, Olivier
Publicado 2023

FACS-assisted single-cell lipidome analysis of phosphatidylcholines and sphingomyelins in cells of different lineages

por Hancock, Sarah E., Ding, Eileen, Johansson Beves, Emma, Mitchell, Todd, Turner, Nigel
Publicado 2023

Hepatocyte estrogen sulfotransferase inhibition protects female mice from concanavalin A–induced T cell–mediated hepatitis independent of estrogens

por Wang, Jingyuan, Zhang, Ziteng, Guan, Jibin, Tung, Hung-Chun, Xie, Jiaxuan, Huang, Haozhe, Chen, Yuang, Xu, Meishu, Ren, Songrong, Li, Song, Zhang, Min, Yang, Da, Xie, Wen
Publicado 2023

Fitm2 is required for ER homeostasis and normal function of murine liver

por Bond, Laura M., Ibrahim, Ayon, Lai, Zon W., Walzem, Rosemary L., Bronson, Roderick T., Ilkayeva, Olga R., Walther, Tobias C., Farese, Robert V.
Publicado 2023

The ROK kinase N-acetylglucosamine kinase uses a sequential random enzyme mechanism with successive conformational changes upon each substrate binding

por Roy, Sumita, Vivoli Vega, Mirella, Ames, Jessica R., Britten, Nicole, Kent, Amy, Evans, Kim, Isupov, Michail N., Harmer, Nicholas J.
Publicado 2023

Interaction of the bacterial division regulator MinE with lipid bicelles studied by NMR spectroscopy

por Cai, Mengli, Tugarinov, Vitali, Chaitanya Chiliveri, Sai, Huang, Ying, Schwieters, Charles D., Mizuuchi, Kyoshi, Clore, G. Marius
Publicado 2023

Mutation of a distal gating residue modulates NADH binding in NADH:Quinone oxidoreductase from Pseudomonas aeruginosa PAO1

por Moni, Bilkis Mehrin, Quaye, Joanna A., Gadda, Giovanni
Publicado 2023

Lipidomic profiling of rat hepatic stellate cells during activation reveals a two-stage process accompanied by increased levels of lysosomal lipids

por Molenaar, Martijn R., Haaker, Maya W., Vaandrager, A. Bas, Houweling, Martin, Helms, J. Bernd
Publicado 2023

Pyridine-containing substrate analogs are restricted from accessing the human cytochrome P450 8B1 active site by tryptophan 281

por Liu, Jinghan, Offei, Samuel D., Yoshimoto, Francis K., Scott, Emily E.
Publicado 2023

The C-terminal domains of ADAMTS1 contain exosites involved in its proteoglycanase activity

por Minns, Alexander Frederick, Qi, Yawei, Yamamoto, Kazuhiro, Lee, Karen, Ahnström, Josefin, Santamaria, Salvatore
Publicado 2023