Loss of mitochondrial ATPase ATAD3A contributes to nonalcoholic fatty liver disease through accumulation of lipids and damaged mitochondria

por Chen, Liting, Li, Yuchang, Sottas, Chantal, Lazaris, Anthoula, Petrillo, Stephanie K., Metrakos, Peter, Li, Lu, Ishida, Yuji, Saito, Takeshi, Garza, Samuel, Papadopoulos, Vassilios
Publicado 2022

High Diversity of Glycosphingolipid Glycans of Colorectal Cancer Cell Lines Reflects the Cellular Differentiation Phenotype

por Wang, Di, Madunić, Katarina, Zhang, Tao, Mayboroda, Oleg A., Lageveen-Kammeijer, Guinevere S.M., Wuhrer, Manfred
Publicado 2022

Protein proximity networks and functional evaluation of the casein kinase 1 gamma family reveal unique roles for CK1γ3 in WNT signaling

por Agajanian, Megan J., Potjewyd, Frances M., Bowman, Brittany M., Solomon, Smaranda, LaPak, Kyle M., Bhatt, Dhaval P., Smith, Jeffery L., Goldfarb, Dennis, Axtman, Alison D., Major, Michael B.
Publicado 2022

Sulfatide with ceramide composed of phytosphingosine (t18:0) and 2-hydroxy FAs in renal intercalated cells

por Nakashima, Keiko, Hirahara, Yukie, Koike, Taro, Tanaka, Susumu, Gamo, Keizo, Oe, Souichi, Hayashi, Shinichi, Seki-Omura, Ryohei, Nakano, Yousuke, Ohe, Chisato, Yoshida, Takashi, Kataoka, Yosky, Tsuda, Masayuki, Yamashita, Tatsuyuki, Honke, Koichi, Kitada, Masaaki
Publicado 2022

A membrane ATPase without transporter activity: Guido Guidotti’s laboratory and the search for CD39

por Oldach, Laurel
Publicado 2022

Cryo-EM structure of the fatty acid reductase LuxC–LuxE complex provides insights into bacterial bioluminescence

por Tian, Qingwei, Wu, Jingting, Xu, Haifeng, Hu, Zhangli, Huo, Yangao, Wang, Liyan
Publicado 2022

Heptanol-mediated phase separation determines phase preference of molecules in live cell membranes

por Gupta, Anjali, Lu, Danqin, Balasubramanian, Harikrushnan, Chi, Zhang, Wohland, Thorsten
Publicado 2022

In vivo regulation of bacterial Rho-dependent transcription termination by the nascent RNA

por Chhakchhuak, Passong Immanual R., Sen, Ranjan
Publicado 2022

ERK/RSK-mediated phosphorylation of Y-box binding protein-1 aggravates diabetic cardiomyopathy by suppressing its interaction with deubiquitinase OTUB1

por Zhong, Xiaodan, Wang, Tao, Zhang, Wenjun, Wang, Mengwen, Xie, Yang, Dai, Lei, He, Xingwei, Madhusudhan, Thati, Zeng, Hesong, Wang, Hongjie
Publicado 2022

Convergent evolution of a parasite-encoded complement control protein-scaffold to mimic binding of mammalian TGF-β to its receptors, TβRI and TβRII

por Mukundan, Ananya, Byeon, Chang-Hyeock, Hinck, Cynthia S., Cunningham, Kyle, Campion, Tiffany, Smyth, Danielle J., Maizels, Rick M., Hinck, Andrew P.
Publicado 2022

microRNA-27b regulates hepatic lipase enzyme LIPC and reduces triglyceride degradation during hepatitis C virus infection

por Desrochers, Geneviève.F., Filip, Roxana, Bastianelli, Micheal, Stern, Tiffany, Pezacki, John Paul
Publicado 2022

Correction: Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling

por Artan, Murat, Barratt, Stephen, Flynn, Sean M., Begum, Farida, Skehel, Mark, Nicolas, Armel, de Bono, Mario
Publicado 2022

Molecular basis for coordinating secondary metabolite production by bacterial and plant signaling molecules

por Zhang, Nannan, Wu, Jin, Zhang, Siping, Yuan, Maoran, Xu, Hang, Li, Jie, Zhang, Pingping, Wang, Mingzhu, Kempher, Megan L., Tao, Xuanyu, Zhang, Li-Qun, Ge, Honghua, He, Yong-Xing
Publicado 2022

The central inflammasome adaptor protein ASC activates the inflammasome after transition from a soluble to an insoluble state

por Prather, Evan R., Gavrilin, Mikhail A., Wewers, Mark D.
Publicado 2022

Structure and role of the linker domain of the iron surface-determinant protein IsdH in heme transportation in Staphylococcus aureus

por Valenciano-Bellido, Sandra, Caaveiro, Jose M.M., Morante, Koldo, Sushko, Tatyana, Nakakido, Makoto, Nagatoishi, Satoru, Tsumoto, Kouhei
Publicado 2022

The dual fates of exogenous tau seeds: Lysosomal clearance versus cytoplasmic amplification

por Kolay, Sourav, Vega, Anthony R., Dodd, Dana A., Perez, Valerie A., Kashmer, Omar M., White, Charles L., Diamond, Marc I.
Publicado 2022

Mechanistic insights into the activation of the IKK kinase complex by the Kaposi’s sarcoma herpes virus oncoprotein vFLIP

por Bagnéris, Claire, Senthil Kumar, Swathi L., Baratchian, Mehdi, Britt, Hannah M., Assafa, Tufa E., Thalassinos, Konstantinos, Collins, Mary K., Barrett, Tracey E.
Publicado 2022

The long β2,3-sheets encoded by redundant sequences play an integral role in the channel function of P2X7 receptors

por Ma, Xue-Fei, Wang, Ting-Ting, Wang, Wen-Hui, Guan, Li, Guo, Chang-Run, Li, Xing-Hua, Lei, Yun-Tao, Fan, Ying-Zhe, Yang, Xiao-Na, Hattori, Motoyuki, Nureki, Osamu, Zhu, Michael X., Yu, Ye, Tian, Yun, Wang, Jin
Publicado 2022

Transmembrane serine protease 2 (TMPRSS2) proteolytically activates the epithelial sodium channel (ENaC) by cleaving the channel’s γ-subunit

por Sure, Florian, Bertog, Marko, Afonso, Sara, Diakov, Alexei, Rinke, Ralf, Madej, M. Gregor, Wittmann, Sabine, Gramberg, Thomas, Korbmacher, Christoph, Ilyaskin, Alexandr V.
Publicado 2022

Nuclear focal adhesion kinase induces APC/C activator protein CDH1-mediated cyclin-dependent kinase 4/6 degradation and inhibits melanoma proliferation

por Murphy, James M., Jeong, Kyuho, Ahn, Eun-Young Erin, Lim, Ssang-Taek Steve
Publicado 2022