Direct anabolic metabolism of three-carbon propionate to a six-carbon metabolite occurs in vivo across tissues and species

por Doan, Mary T., Neinast, Michael D., Varner, Erika L., Bedi, Kenneth C., Bartee, David, Jiang, Helen, Trefely, Sophie, Xu, Peining, Singh, Jay P., Jang, Cholsoon, Rame, J. Eduardo, Brady, Donita C., Meier, Jordan L., Marguiles, Kenneth B., Arany, Zoltan, Snyder, Nathaniel W.
Publicado 2022

Transcription factors KLF15 and PPARδ cooperatively orchestrate genome-wide regulation of lipid metabolism in skeletal muscle

por Fan, Liyan, Sweet, David R., Fan, Erica K., Prosdocimo, Domenick A., Madera, Annmarie, Jiang, Zhen, Padmanabhan, Roshan, Haldar, Saptarsi M., Vinayachandran, Vinesh, Jain, Mukesh K.
Publicado 2022

Giardia intestinalis thymidine kinase is a high-affinity enzyme crucial for DNA synthesis and an exploitable target for drug discovery

por Krakovka, Sascha, Ranjbarian, Farahnaz, Luján, Lucas A., Saura, Alicia, Larsen, Nicolai B., Jiménez-González, Alejandro, Reggenti, Anna, Luján, Hugo D., Svärd, Staffan G., Hofer, Anders
Publicado 2022

Heparin activation of protein Z-dependent protease inhibitor (ZPI) allosterically blocks protein Z activation through an extended heparin-binding site

por Huang, Xin, Swanson, Richard, Olson, Steven T.
Publicado 2022

Structure, dynamics, and molecular inhibition of the Staphylococcus aureus m(1)A22-tRNA methyltransferase TrmK

por Sweeney, Pamela, Galliford, Ashleigh, Kumar, Abhishek, Raju, Dinesh, Krishna, Naveen B., Sutherland, Emmajay, Leo, Caitlin J., Fisher, Gemma, Lalitha, Roopa, Muthuraj, Likith, Sigamani, Gladstone, Oehler, Verena, Synowsky, Silvia, Shirran, Sally L., Gloster, Tracey M., Czekster, Clarissa M., Kumar, Pravin, da Silva, Rafael G.
Publicado 2022

Ubiquitin-conjugating activity by PEX4 is required for efficient protein transport to peroxisomes in Arabidopsis thaliana

por Mano, Shoji, Hayashi, Yasuko, Hikino, Kazumi, Otomo, Masayoshi, Kanai, Masatake, Nishimura, Mikio
Publicado 2022

Plasma membrane proteoglycans syndecan-2 and syndecan-4 engage with EGFR and RON kinase to sustain carcinoma cell cycle progression

por Beauvais, DeannaLee M., Nelson, Scott E., Adams, Kristin M., Stueven, Noah A., Jung, Oisun, Rapraeger, Alan C.
Publicado 2022

Palmitoylation of the small GTPase Cdc42 by DHHC5 modulates spine formation and gene transcription

por Wirth, Alexander, Labus, Josephine, Abdel Galil, Dalia, Schill, Yvonne, Schmidt, Silke, Bunke, Tania, Gorinski, Nataliya, Yokoi, Norihiko, Fukata, Masaki, Ponimaskin, Evgeni
Publicado 2022

SGK1 negatively regulates inflammatory immune responses and protects against alveolar bone loss through modulation of TRAF3 activity

por Han, Xiao, Ren, Junling, Lohner, Hannah, Yakoumatos, Lan, Liang, Ruqiang, Wang, Huizhi
Publicado 2022

Alternative splicing of the human rhomboid family-1 gene RHBDF1 inhibits epidermal growth factor receptor activation

por Ji, Renpeng, Shi, Qianqian, Cao, Yixin, Zhang, Jingyue, Zhao, Cancan, Zhao, Huanyu, Sayyed, Yasra, Fu, Li, Li, Lu-Yuan
Publicado 2022

MRAP2 inhibits β-arrestin recruitment to the ghrelin receptor by preventing GHSR1a phosphorylation

por Rouault, Alix A.J., Buscaglia, Paul, Sebag, Julien A.
Publicado 2022

A novel Cbx1, PurB, and Sp3 complex mediates long-term silencing of tissue- and lineage-specific genes

por Baksh, Syeda Samara, Pratt, Richard E., Gomez, José, Dzau, Victor J., Hodgkinson, Conrad P.
Publicado 2022

Adaptations of the 3T3-L1 adipocyte lipidome to defective ether lipid catabolism upon Agmo knockdown

por Sailer, Sabrina, Lackner, Katharina, Pras-Raves, Mia L., Wever, Eric J.M., van Klinken, Jan B., Dane, Adriaan D., Geley, Stephan, Koch, Jakob, Golderer, Georg, Werner-Felmayer, Gabriele, Keller, Markus A., Zwerschke, Werner, Vaz, Frédéric M., Werner, Ernst R., Watschinger, Katrin
Publicado 2022

ω-O-Acylceramides but not ω-hydroxy ceramides are required for healthy lamellar phase architecture of skin barrier lipids

por Opálka, Lukáš, Meyer, Jason M., Ondrejčeková, Veronika, Svatošová, Linda, Radner, Franz P.W., Vávrová, Kateřina
Publicado 2022

A novel small-molecule selective activator of homomeric GIRK4 channels

por Cui, Meng, Xu, Keman, Gada, Kirin D., Shalomov, Boris, Ban, Michelle, Eptaminitaki, Giasemi C., Kawano, Takeharu, Plant, Leigh D., Dascal, Nathan, Logothetis, Diomedes E.
Publicado 2022

ImShot: An Open-Source Software for Probabilistic Identification of Proteins In Situ and Visualization of Proteomics Data

por Aftab, Wasim, Lahiri, Shibojyoti, Imhof, Axel
Publicado 2022

Brain-derived neurotrophic factor regulates LYN kinase–mediated myosin light chain kinase activation to modulate nonmuscle myosin II activity in hippocampal neurons

por Li, Xiaobing, Yuan, Rong-Rong, Wang, Qixia, Chai, Shouyu, Zhang, Zhengying, Wang, Yue, Huang, Shu-Hong
Publicado 2022

Fueling genome maintenance: On the versatile roles of NAD(+) in preserving DNA integrity

por Ruszkiewicz, Joanna A., Bürkle, Alexander, Mangerich, Aswin
Publicado 2022

Prolonged deprivation of arginine or leucine induces PI3K/Akt-dependent reactivation of mTORC1

por Buel, Gwen R., Dang, Huy Q., Asara, John M., Blenis, John, Mutvei, Anders P.
Publicado 2022

A novel LncRNA PTH-AS upregulates interferon-related DNA damage resistance signature genes and promotes metastasis in human breast cancer xenografts

por Akimoto, Miho, Susa, Takao, Okudaira, Noriyuki, Hisaki, Harumi, Iizuka, Masayoshi, Okinaga, Hiroko, Okazaki, Tomoki, Tamamori-Adachi, Mimi
Publicado 2022