Structural basis for transcription factor ZBTB7A recognition of DNA and effects of ZBTB7A somatic mutations that occur in human acute myeloid leukemia

por Ren, Ren, Horton, John R., Chen, Qin, Yang, Jie, Liu, Bin, Huang, Yun, Blumenthal, Robert M., Zhang, Xing, Cheng, Xiaodong
Publicado 2023

Endoplasmic reticulum protein BIK binds to and inhibits mitochondria-localized antiapoptotic proteins

por Osterlund, Elizabeth J., Hirmiz, Nehad, Nguyen, Dang, Pemberton, James M., Fang, Qiyin, Andrews, David W.
Publicado 2023

Stromal cell-derived NGF controls sympathetic innervation in subcutaneous fat

por Meng, Xia, Chen, Jian, Zeng, Wenwen
Publicado 2022

Dysregulated ceramide metabolism in mouse progressive dermatitis resulting from constitutive activation of Jak1

por Iino, Yudai, Naganuma, Tatsuro, Arita, Makoto
Publicado 2023

Overexpression of Pdx1, reduction of p53, or deletion of CHOP attenuates pancreas hypoplasia in mice with pancreas-specific O-GlcNAc transferase deletion

por Wong, Alicia, Pritchard, Samantha, Moore, Mackenzie, Akhaphong, Brian, Avula, Nandini, Beetch, Megan, Fujitani, Yoshio, Alejandro, Emilyn U.
Publicado 2023

Serum opacity factor rescues fertility among female Scarb1(−/−) mice by reducing HDL-free cholesterol bioavailability

por Rosales, Corina, Yelamanchili, Dedipya, Gillard, Baiba K., Liu, Jing, Gotto, Antonio M., Pownall, Henry J.
Publicado 2022

Structural insights into protection against a SARS-CoV-2 spike variant by T cell receptor diversity

por Wu, Daichao, Efimov, Grigory A., Bogolyubova, Apollinariya V., Pierce, Brian G., Mariuzza, Roy A.
Publicado 2023

Structures of the NDP-pyranose mutase belonging to glycosyltransferase family 75 reveal residues important for Mn(2+) coordination and substrate binding

por Du, Xueqing, Chu, Xuan, Liu, Ning, Jia, Xiaoyu, Peng, Hui, Xiao, Yazhong, Liu, Lin, Yu, Haizhu, Li, Fudong, He, Chao
Publicado 2023

Hierarchical assembly of the MLL1 core complex regulates H3K4 methylation and is dependent on temperature and component concentration

por Namitz, Kevin E.W., Tan, Song, Cosgrove, Michael S.
Publicado 2023

Natural and synthetic 2-oxoglutarate derivatives are substrates for oncogenic variants of human isocitrate dehydrogenase 1 and 2

por Liu, Xiao, Reinbold, Raphael, Liu, Shuang, Herold, Ryan A., Rabe, Patrick, Duclos, Stéphanie, Yadav, Rahul B., Abboud, Martine I., Thieffine, Sandrine, Armstrong, Fraser A., Brewitz, Lennart, Schofield, Christopher J.
Publicado 2023

Quantification and Proteomic Characterization of β-Hydroxybutyrylation Modification in the Hearts of AMPKα2 Knockout Mice

por Ding, Wen-jing, Li, Xue-hui, Tang, Cong-min, Yang, Xue-chun, Sun, Yan, Song, Yi-ping, Ling, Ming-ying, Yan, Rong, Gao, Hai-qing, Zhang, Wen-hua, Yu, Na, Feng, Jun-chao, Zhang, Zhen, Xing, Yan-qiu
Publicado 2023

Protein engineering reveals that gasdermin A preferentially targets mitochondrial membranes over the plasma membrane during pyroptosis

por Kondolf, Hannah C., D'Orlando, Dana A., Dubyak, George R., Abbott, Derek W.
Publicado 2023

Agonist-controlled competition of RAR and VDR nuclear receptors for heterodimerization with RXR is manifested in their DNA binding

por Rehó, Bálint, Fadel, Lina, Brazda, Peter, Benziane, Anass, Hegedüs, Éva, Sen, Pialy, Gadella, Theodorus W.J., Tóth, Katalin, Nagy, László, Vámosi, György
Publicado 2023

Integrated Single-Cell (Phospho-)Protein and RNA Detection Uncovers Phenotypic Characteristics and Active Signal Transduction of Human Antibody-Secreting Cells

por van Buijtenen, Erik, Janssen, Wout, Vink, Paul, Habraken, Maurice J.M., Wingens, Laura J.A., van Elsas, Andrea, Huck, Wilhelm T.S., van Buggenum, Jessie A.G.L., van Eenennaam, Hans
Publicado 2023

Assembly chaperone Nas6 selectively destabilizes 26S proteasomes with defective regulatory particle-core particle interfaces

por Warnock, Jennifer L., Jobin, Gabriel W., Kumar, Sandhya, Tomko, Robert J.
Publicado 2023

AepG is a glucuronosyltransferase involved in acidic exopolysaccharide synthesis and contributes to environmental adaptation of Haloarcula hispanica

por Pei, Caixia, Lu, Hua, Ma, Jiayin, Eichler, Jerry, Guan, Ziqiang, Gao, Linlu, Liu, Li, Zhou, Hui, Yang, Jinghua, Jin, Cheng
Publicado 2023

Presynaptic Gq-coupled receptors drive biphasic dopamine transporter trafficking that modulates dopamine clearance and motor function

por Kearney, Patrick J., Bolden, Nicholas C., Kahuno, Elizabeth, Conklin, Tucker L., Martin, Gilles E., Lubec, Gert, Melikian, Haley E.
Publicado 2023

Untranslated regions of brain-derived neurotrophic factor mRNA control its translatability and subcellular localization

por Lekk, Ingrid, Cabrera-Cabrera, Florencia, Turconi, Giorgio, Tuvikene, Jürgen, Esvald, Eli-Eelika, Rähni, Annika, Casserly, Laoise, Garton, Daniel R., Andressoo, Jaan-Olle, Timmusk, Tõnis, Koppel, Indrek
Publicado 2023

Genetic deletion or pharmacologic inhibition of the Nlrp3 inflammasome did not ameliorate experimental NASH

por Ioannou, George N., Horn, Christian L., Kothari, Vishal, Yeh, Matthew M., Shyu, Irene, Lee, Sum P., Savard, Christopher E.
Publicado 2023

HECT domain interaction with ubiquitin binding sites on Tsg101-UEV controls HIV-1 egress, maturation, and infectivity

por Nyenhuis, David A., Rajasekaran, Rohith, Watanabe, Susan, Strub, Marie-Paule, Khan, Mahfuz, Powell, Michael, Carter, Carol A., Tjandra, Nico
Publicado 2023