Targeted protein posttranslational modifications by chemically induced proximity for cancer therapy

por Peng, Yunhua, Liu, Jing, Inuzuka, Hiroyuki, Wei, Wenyi
Publicado 2023

SARS-CoV-2 Variants Show Different Host Cell Proteome Profiles With Delayed Immune Response Activation in Omicron-Infected Cells

por Metzler, Melinda, Tharyan, Rebecca George, Klann, Kevin, Grikscheit, Katharina, Bojkova, Denisa, Cinatl, Jindrich, Tascher, Georg, Ciesek, Sandra, Münch, Christian
Publicado 2023

Heat shock protein 90 facilitates SARS-CoV-2 structural protein-mediated virion assembly and promotes virus-induced pyroptosis

por Zhao, Zhuangzhuang, Xu, Ling-Dong, Zhang, Fei, Liang, Qi-Zhang, Jiao, Yajuan, Shi, Fang-Shu, He, Biao, Xu, Pinglong, Huang, Yao-Wei
Publicado 2023

SARS-CoV-2 polyprotein substrate regulates the stepwise M(pro) cleavage reaction

por Narwal, Manju, Armache, Jean-Paul, Edwards, Thomas J., Murakami, Katsuhiko S.
Publicado 2023

SARS-CoV-2 spike ectodomain targets α7 nicotinic acetylcholine receptors

por O’Brien, Brittany C.V., Weber, Lahra, Hueffer, Karsten, Weltzin, Maegan M.
Publicado 2023

Inhibition of exchange proteins directly activated by cAMP as a strategy for broad-spectrum antiviral development

por Boulton, Stephen, Crupi, Mathieu J.F., Singh, Siddharth, Carter-Timofte, Madalina E., Azad, Taha, Organ, Bailey C., He, Xiaohong, Gill, Rida, Neault, Serge, Jamieson, Taylor, Dave, Jaahnavi, Kurmasheva, Naziia, Austin, Bradley, Petryk, Julia, Singaravelu, Ragunath, Huang, Ben Zhen, Franco, Noah, Babu, Kaaviya, Parks, Robin J., Ilkow, Carolina S., Olagnier, David, Bell, John C.
Publicado 2023

Differential role for rapid proteostasis in Rho GTPase-mediated control of quiescent endothelial integrity

por Podieh, Fabienne, Wensveen, Roos, Overboom, Max C., Abbas, Lotte, Majolée, Jisca, Hordijk, Peter L.
Publicado 2023

Phosphatase regulatory subunit MYPT2 knockout partially compensates for the cardiac dysfunction in mice caused by lack of myosin light chain kinase 3

por Hu, Tingfei, Kalyanaraman, Hema, Pilz, Renate B., Casteel, Darren E.
Publicado 2023

Atypical histone targets of PHD fingers

por Black, Joshua C., Kutateladze, Tatiana G.
Publicado 2023

Activation of Gcn2 by small molecules designed to be inhibitors

por Carlson, Kenneth R., Georgiadis, Millie M., Tameire, Feven, Staschke, Kirk A., Wek, Ronald C.
Publicado 2023

The Ycx1 protein encoded by the yeast YDL206W gene plays a role in calcium and calcineurin signaling

por Lee, Grace M., Weng, Fangli, Cranley, Juliana, Rajasekhar, Abhinav, Stoeckel, Matthew, Kane, Thomas, Tisi, Renata, Wang, Yuqi
Publicado 2023

Structural insights into a cooperative switch between one and two FimH bacterial adhesins binding pauci- and high-mannose type N-glycan receptors

por Krammer, Eva-Maria, Bridot, Clarisse, Serna, Sonia, Echeverria, Begoña, Semwal, Shubham, Roubinet, Benoît, van Noort, Kim, Wilbers, Ruud H.P., Bourenkov, Gleb, de Ruyck, Jérôme, Landemarre, Ludovic, Reichardt, Niels, Bouckaert, Julie
Publicado 2023

Retinal-phospholipid Schiff-base conjugates and their interaction with ABCA4, the ABC transporter associated with Stargardt disease

por Xu, Tongzhou, Molday, Laurie L., Molday, Robert S.
Publicado 2023

H(2)O(2) transit through the mitochondrial intermembrane space promotes tumor cell growth in vitro and in vivo

por Sabharwal, Simran S., Dudley, V. Joseph, Landwerlin, Charlène, Schumacker, Paul T.
Publicado 2023

Molecular mechanism of tRNA binding by the Escherichia coli N7 guanosine methyltransferase TrmB

por Schultz, Sarah K., Meadows, Kieran, Kothe, Ute
Publicado 2023

Single-molecule dynamics of DNA gyrase in evolutionarily distant bacteria Mycobacterium tuberculosis and Escherichia coli

por Galvin, Cooper J., Hobson, Matthew, Meng, Jonathan Xianglong, Ierokomos, Athena, Ivanov, Ivan E., Berger, James M., Bryant, Zev
Publicado 2023

Identification of GPI-anchored protein LYPD1 as an essential factor for odontoblast differentiation in tooth development

por Fu, Yao, Miyazaki, Kanako, Chiba, Yuta, Funada, Keita, Yuta, Tomomi, Tian, Tian, Mizuta, Kanji, Kawahara, Jumpei, Zhang, Ling, Martin, Daniel, Iwamoto, Tsutomu, Takahashi, Ichiro, Fukumoto, Satoshi, Yoshizaki, Keigo
Publicado 2023

PI3Kα Translocation Mediates Nuclear PtdIns(3,4,5)P(3) Effector Signaling in Colorectal Cancer

por Palmieri, Michelle, Catimel, Bruno, Mouradov, Dmitri, Sakthianandeswaren, Anuratha, Kapp, Eugene, Ang, Ching-Seng, Williamson, Nicholas A., Nowell, Cameron J., Christie, Michael, Desai, Jayesh, Gibbs, Peter, Burgess, Antony W., Sieber, Oliver M.
Publicado 2023

Designer molecules of the synaptic organizer MDGA1 reveal 3D conformational control of biological function

por Lee, Hubert, Chofflet, Nicolas, Liu, Jianfang, Fan, Shanghua, Lu, Zhuoyang, Resua Rojas, Martin, Penndorf, Patrick, Bailey, Aaron O., Russell, William K., Machius, Mischa, Ren, Gang, Takahashi, Hideto, Rudenko, Gabby
Publicado 2023

Escherichia coli has robust regulatory mechanisms against elevated peptidoglycan cleavage by lytic transglycosylases

por Liang, Yaquan, Zhao, Yilin, Kwan, Jeric Mun Chung, Wang, Yue, Qiao, Yuan
Publicado 2023