Structures of an unusual 3-hydroxyacyl dehydratase (FabZ) from a ladderane-producing organism with an unexpected substrate preference

por Dietl, Andreas, Wellach, Kathrin, Mahadevan, Pavithra, Mertes, Nicole, Winter, Sophie L., Kutsch, Tobias, Walz, Carlo, Schlichting, Ilme, Fabritz, Sebastian, Barends, Thomas R.M.
Publicado 2023

Evolutionary conservation of sequence motifs at sites of protein modification

por Li, Shuang, Dohlman, Henrik G.
Publicado 2023

Mutagenesis and structural analysis reveal the CTX-M β-lactamase active site is optimized for cephalosporin catalysis and drug resistance

por Lu, Shuo, Montoya, Miranda, Hu, Liya, Neetu, Neetu, Sankaran, Banumathi, Prasad, B.V. Venkataram, Palzkill, Timothy
Publicado 2023

The histamine H3 receptor modulates dopamine D2 receptor–dependent signaling pathways and mouse behaviors

por Xu, Jian, Pittenger, Christopher
Publicado 2023

The role of high cholesterol in SARS-CoV-2 infectivity

por Wang, Hao, Yuan, Zixuan, Pavel, Mahmud Arif, Jablonski, Sonia Mediouni, Jablonski, Joseph, Hobson, Robert, Valente, Susana, Reddy, Chakravarthy B., Hansen, Scott B.
Publicado 2023

Correction: Residues forming the gating regions of asymmetric multidrug transporter Pdr5 also play roles in conformational switching and protein folding

por Alhumaidi, Maryam, Nentwig, Lea-Marie, Rahman, Hadiar, Schmitt, Lutz, Rudrow, Andrew, Harris, Andrzej, Dillon, Cierra, Restrepo, Lucas, Lamping, Erwin, Arya, Nidhi, Ambudkar, Suresh V., Choy, John S., Golin, John
Publicado 2023

Structural basis for reduced ribosomal A-site fidelity in response to P-site codon–anticodon mismatches

por Nguyen, Ha An, Hoffer, Eric D., Fagan, Crystal E., Maehigashi, Tatsuya, Dunham, Christine M.
Publicado 2023

Molecular determinants for differential activation of the bile acid receptor from the pathogen Vibrio parahaemolyticus

por Zou, Angela J., Kinch, Lisa, Chimalapati, Suneeta, Garcia, Nalleli, Tomchick, Diana R., Orth, Kim
Publicado 2023

Cryo-EM reveals the membrane-binding phenomenon of EspB, a virulence factor of the mycobacterial type VII secretion system

por Sengupta, Nayanika, Padmanaban, Surekha, Dutta, Somnath
Publicado 2023

A bivalent β-carboline derivative inhibits macropinocytosis-dependent entry of pseudorabies virus by targeting the kinase DYRK1A

por Wang, Chongyang, Hu, Ruochen, Wang, Ting, Duan, Liuyuan, Hou, Qili, Wang, Junru, Yang, Zengqi
Publicado 2023

Structures of calmodulin–melittin complexes show multiple binding modes lacking classical anchoring interactions

por Dürvanger, Zsolt, Juhász, Tünde, Liliom, Károly, Harmat, Veronika
Publicado 2023

Bifunctional DEGS2 has higher hydroxylase activity toward substrates with very-long-chain fatty acids in the production of phytosphingosine ceramides

por Ota, Ai, Morita, Hiroya, Naganuma, Tatsuro, Miyamoto, Masatoshi, Jojima, Keisuke, Nojiri, Koki, Matsuda, Junko, Kihara, Akio
Publicado 2023

Differential regulation of phosphorylation, structure, and stability of circadian clock protein FRQ isoforms

por Chen, Xianyun, Liu, Xiaolan, Gan, Xihui, Li, Silin, Ma, Huan, Zhang, Lin, Wang, Peiliang, Li, Yunzhen, Huang, Tianyu, Yang, Xiaolin, Fang, Ling, Liang, Yingying, Wu, Jingjing, Chen, Tongyue, Zhou, Zengxuan, Liu, Xiao, Guo, Jinhu
Publicado 2023

Egg envelope formation of medaka Oryzias latipes requires ZP proteins originating from both the liver and ovary

por Yokokawa, Reo, Watanabe, Kana, Kanda, Shinji, Nishino, Yoshihide, Yasumasu, Shigeki, Sano, Kaori
Publicado 2023

Glycolipid transfer protein knockout disrupts vesicle trafficking to the plasma membrane

por Nurmi, Henrik, Backman, Anders P.E., Halin, Josefin, Lönnfors, Max, Blom, Tomas, Roos-Mattjus, Pia, Mattjus, Peter
Publicado 2023

Distinct effects of two hearing loss–associated mutations in the sarcomeric myosin MYH7b

por Lee, Lindsey A., Barrick, Samantha K., Buvoli, Ada E., Walklate, Jonathan, Stump, W. Tom, Geeves, Michael, Greenberg, Michael J., Leinwand, Leslie A.
Publicado 2023

RNA-Seq reveals that overexpression of TcUBP1 switches the gene expression pattern toward that of the infective form of Trypanosoma cruzi

por Sabalette, Karina B., Sotelo-Silveira, José R., Smircich, Pablo, De Gaudenzi, Javier G.
Publicado 2023

TRIM28 represses renal cell carcinoma cell proliferation by inhibiting TFE3/KDM6A-regulated autophagy

por Song, Tanjing, Lv, Suli, Ma, Xianyun, Zhao, Xuefeng, Fan, Li, Zou, Qingli, Li, Neng, Yan, Yingying, Zhang, Wen, Sun, Lidong
Publicado 2023

Modulating CD40 and integrin signaling in the proinflammatory nexus using a 15-amino-acid peptide, KGYY(15)

por Vaitaitis, Gisela M., Wagner, David H.
Publicado 2023

The bacterial nucleoid-associated proteins, HU and Dps, condense DNA into context-dependent biphasic or multiphasic complex coacervates

por Gupta, Archit, Joshi, Ashish, Arora, Kanika, Mukhopadhyay, Samrat, Guptasarma, Purnananda
Publicado 2023