HSP90α is needed for the survival of rod photoreceptors and regulates the expression of rod PDE6 subunits

por Munezero, Daniella, Aliff, Hunter, Salido, Ezequiel, Saravanan, Thamaraiselvi, Sanzhaeva, Urikhan, Guan, Tongju, Ramamurthy, Visvanathan
Publicado 2023

Hes1 marks peri-condensation mesenchymal cells that generate both chondrocytes and perichondrial cells in early bone development

por Matsushita, Yuki, Manabe, Hiroaki, Ohyama, Takahiro, Nakamura, Shogo, Nagata, Mizuki, Ono, Wanida, Ono, Noriaki
Publicado 2023

Computational engineering of previously crystallized pyruvate formate-lyase activating enzyme reveals insights into SAM binding and reductive cleavage

por Moody, James D., Hill, Sarah, Lundahl, Maike N., Saxton, Aubrianna J., Galambas, Amanda, Broderick, William E., Lawrence, C. Martin, Broderick, Joan B.
Publicado 2023

A novel BRET-based assay to investigate binding and residence time of unmodified ligands to the human lysosomal ion channel TRPML1 in intact cells

por Cunha, Micael R., Catta-Preta, Carolina M.C., Takarada, Jéssica E., Moreira, Gabriela A., Massirer, Katlin B., Couñago, Rafael M.
Publicado 2023

Oxidation of caspase-8 by hypothiocyanous acid enables TNF-mediated necroptosis

por Bozonet, Stephanie M., Magon, Nicholas J., Schwartfeger, Abigail J., Konigstorfer, Andreas, Heath, Sarah G., Vissers, Margreet C.M., Morris, Vanessa K., Göbl, Christoph, Murphy, James M., Salvesen, Guy S., Hampton, Mark B.
Publicado 2023

Characterization of the cholesterol biosynthetic pathway in Dioscorea transversa

por Salisbury, Lauren J., Fletcher, Stephen J., Stok, Jeanette E., Churchman, Luke R., Blanchfield, Joanne T., De Voss, James J.
Publicado 2023

Structural basis of ELKS/Rab6B interaction and its role in vesicle capturing enhanced by liquid-liquid phase separation

por Jin, Gaowei, Lin, Leishu, Li, Kaiyue, Li, Jiashan, Yu, Cong, Wei, Zhiyi
Publicado 2023

Robust and High-Throughput Analytical Flow Proteomics Analysis of Cynomolgus Monkey and Human Matrices With Zeno SWATH Data-Independent Acquisition

por Sun, Weiwen, Lin, Yuan, Huang, Yue, Chan, Josolyn, Terrillon, Sonia, Rosenbaum, Anton I., Contrepois, Kévin
Publicado 2023

Degradomic Identification of Membrane Type 1-Matrix Metalloproteinase as an ADAMTS9 and ADAMTS20 Substrate

por Nandadasa, Sumeda, Martin, Daniel, Deshpande, Gauravi, Robert, Karyn L., Stack, M. Sharon, Itoh, Yoshifumi, Apte, Suneel S.
Publicado 2023

A web-based integrative transcriptome analysis, RNAseqChef, uncovers the cell/tissue type-dependent action of sulforaphane

por Etoh, Kan, Nakao, Mitsuyoshi
Publicado 2023

High immunoglobulin-M levels to oxidation-specific epitopes are associated with lower risk of acute myocardial infarction

por Taleb, Adam, Willeit, Peter, Amir, Shahzada, Perkmann, Thomas, Kozma, Maria Ozsvar, Watzenböck, Martin L., Binder, Christoph J., Witztum, Joseph L., Tsimikas, Sotirios
Publicado 2023

Human TMEM2 is not a catalytic hyaluronidase, but a regulator of hyaluronan metabolism via HYBID (KIAA1199/CEMIP) and HAS2 expression

por Sato, Shinya, Miyazaki, Megumi, Fukuda, Shinji, Mizutani, Yukiko, Mizukami, Yoichi, Higashiyama, Shigeki, Inoue, Shintaro
Publicado 2023

Characteristic fragmentation of polyunsaturated fatty acids with allylic vicinal diols in positive-ion LC/ESI-MS/MS

por Zhu, Huibin, Kurokawa, Mone, Chen, Mengyao, Wang, Qiuyi, Inoue, Masayuki, Takao, Toshifumi
Publicado 2023

Development of the nonreceptor tyrosine kinase FER-targeting PROTACs as a potential strategy for antagonizing ovarian cancer cell motility and invasiveness

por Zhang, Yanchun, Xiong, Xuexue, Sun, Renhong, Zhu, Xiaotong, Wang, Chen, Jiang, Biao, Yang, Xiaobao, Li, Dake, Fan, Gaofeng
Publicado 2023

Plasmodium parasitophorous vacuole membrane protein Pfs16 promotes malaria transmission by silencing mosquito immunity

por Ramelow, Julian, Keleta, Yacob, Niu, Guodong, Wang, Xiaohong, Li, Jun
Publicado 2023

Circadian PER1 controls daily fat absorption with the regulation of PER1-PKA on phosphorylation of bile acid synthetase

por Ge, Wenhao, Sun, Qi, Yang, Yunxia, Ding, Zhao, Liu, Junhao, Zhang, Jianfa
Publicado 2023

The NSs protein of severe fever with thrombocytopenia syndrome virus differentially inhibits the type 1 interferon response among animal species

por Yoshikawa, Rokusuke, Kawakami, Masahiro, Yasuda, Jiro
Publicado 2023

A vital role for PICK1 in the differential regulation of metabotropic glutamate receptor internalization and synaptic AMPA receptor endocytosis

por Ramsakha, Namrata, Ojha, Prachi, Pal, Subhajit, Routh, Sanjeev, Citri, Ami, Bhattacharyya, Samarjit
Publicado 2023

Ceramide analog C2-cer induces a loss in insulin sensitivity in muscle cells through the salvage/recycling pathway

por Bandet, Cécile L., Tan-Chen, Sophie, Ali-Berrada, Sarah, Campana, Mélanie, Poirier, Maxime, Blachnio-Zabielska, Agnieszka, Pais-de-Barros, Jean-Paul, Rouch, Claude, Ferré, Pascal, Foufelle, Fabienne, Le Stunff, Hervé, Hajduch, Eric
Publicado 2023

Diarylheptanoid 35d overcomes EGFR TKI resistance by inducing hsp70-mediated lysosomal degradation of EGFR in EGFR-mutant lung adenocarcinoma

por Hong, Xuan, Hsieh, Min-Tsang, Tseng, Tzu-Yu, Lin, Hui-Yi, Chang, Hung-Chih, Yau, Sir-Theng, Cheng, Wei-Chung, Ke, Baozhen, Liao, Hsiao-Hui, Wu, Chih-Ying, Liu, An-An, Wu, Meei-Maan, Huang, Kuo-Yen, Yang, Pan-Chyr, Kuo, Sheng-Chu, Hung, Mien-Chie, Lee, Pei-Chih
Publicado 2023