In vivo and in vitro characterizations of melibiose permease (MelB) conformation-dependent nanobodies reveal sugar-binding mechanisms

por Katsube, Satoshi, Willibal, Katleen, Vemulapally, Sangama, Hariharan, Parameswaran, Tikhonova, Elena, Pardon, Els, Kaback, H. Ronald, Steyaert, Jan, Guan, Lan
Publicado 2023

Vpx requires active cellular dNTP biosynthesis to effectively counteract the anti-lentivirus activity of SAMHD1 in macrophages

por Bowen, Nicole E., Tao, Sijia, Cho, Young-Jae, Schinazi, Raymond F., Kim, Baek
Publicado 2023

Gi/o GPCRs drive the formation of actin-rich tunneling nanotubes in cancer cells via a Gβγ/PKCα/FARP1/Cdc42 axis

por Cooke, Mariana, Zhang, Suli, Cornejo Maciel, Fabiana, Kazanietz, Marcelo G.
Publicado 2023

Inhibition of cleavage of human complement component C5 and the R885H C5 variant by two distinct high affinity anti-C5 nanobodies

por Struijf, Eva M., De la O Becerra, Karla I., Ruyken, Maartje, de Haas, Carla J.C., van Oosterom, Fleur, Siere, Danique Y., van Keulen, Joanne E., Heesterbeek, Dani A.C., Dolk, Edward, Heukers, Raimond, Bardoel, Bart W., Gros, Piet, Rooijakkers, Suzan H.M.
Publicado 2023

Cataract-causing Y204X mutation of crystallin protein CRYβB1 promotes its C-terminal degradation and higher-order oligomerization

por Jing, Xuping, Zhu, Mingwei, Lu, Xiaoyun, Wei, Ping, Shi, Lingyu, Zhang, Bu-Yu, Xu, Yi, Tang, Ya-Ping, Xiang, Dao-Man, Gong, Peng
Publicado 2023

The collagen ColQ binds to LRP4 and regulates the activation of the Muscle-Specific Kinase–LRP4 receptor complex by agrin at the neuromuscular junction

por Uyen Dao, Thi Minh, Barbeau, Susie, Messéant, Julien, Della-Gaspera, Bruno, Bouceba, Tahar, Semprez, Fannie, Legay, Claire, Dobbertin, Alexandre
Publicado 2023

Rpb7 represses transcription-coupled nucleotide excision repair

por Gong, Wenzhi, Li, Shisheng
Publicado 2023

The Hylemon-Björkhem pathway of bile acid 7-dehydroxylation: history, biochemistry, and microbiology

por Ridlon, Jason M., Daniel, Steven L., Gaskins, H. Rex
Publicado 2023

Single amino acid–based PROTACs trigger degradation of the oncogenic kinase BCR–ABL in chronic myeloid leukemia (CML)

por Zhang, Jianchao, Ma, Caibing, Yu, Yongjun, Liu, Chaowei, Fang, Lijing, Rao, Hai
Publicado 2023

Different conformational dynamics of SNARE protein Ykt6 among yeast and mammals

por Ji, Jie, Yu, Yiping, Wu, Shaowen, Wang, Dongdong, Weng, Jingwei, Wang, Wenning
Publicado 2023

The lipogenic enzyme acetoacetyl-CoA synthetase and ketone body utilization for denovo lipid synthesis, a review

por Bergstrom, James D.
Publicado 2023

Human cytochrome P450 3A7 binding four copies of its native substrate dehydroepiandrosterone 3-sulfate

por Liu, Jinghan, Kandel, Sylvie E., Lampe, Jed N., Scott, Emily E.
Publicado 2023

Persistent ER stress causes GPI anchor deficit to convert a GPI-anchored prion protein into pro-PrP via the ATF6–miR449c-5p–PIGV axis

por Li, JingFeng, Li, SaSa, Yu, ShuPei, Yang, Jie, Ke, JingRu, Li, Huan, Chen, Heng, Lu, MingJian, Sy, Man-Sun, Gao, ZhenXing, Li, Chaoyang
Publicado 2023

Full-length nuclear receptor allosteric regulation

por Choi, Woong Jae, Haratipour, Zeinab, Blind, Raymond D.
Publicado 2023

Striatal mGlu(5)-mediated synaptic plasticity is independently regulated by location-specific receptor pools and divergent signaling pathways

por Jong, Yuh-Jiin I., Izumi, Yukitoshi, Harmon, Steven K., Zorumski, Charles F., ÓMalley, Karen L.
Publicado 2023

Proteogenomic Features of the Highly Polymorphic Histidine-rich Glycoprotein Arose Late in Evolution

por Zou, Yang, van Breukelen, Bas, Pronker, Matti, Reiding, Karli, Heck, Albert J.R.
Publicado 2023

An Inflection Point in Cancer Protein Biomarkers: What was and What's Next

por Barker, Anna D., Alba, Mario M., Mallick, Parag, Agus, David B., Lee, Jerry S.H.
Publicado 2023

MS-Based Proteomics of Body Fluids: The End of the Beginning

por Bader, Jakob M., Albrecht, Vincent, Mann, Matthias
Publicado 2023

Functional Impact of Protein–RNA Variation in Clinical Cancer Analyses

por Arad, Gali, Geiger, Tamar
Publicado 2023

Functional and Clinical Proteomic Exploration of Pancreatic Cancer

por Huang, Peiwu, Gao, Weina, Fu, Changying, Tian, Ruijun
Publicado 2023