Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation

por O’Neill, Audrey G., Burrell, Anika L., Zech, Michael, Elpeleg, Orly, Harel, Tamar, Edvardson, Simon, Mor-Shaked, Hagar, Rippert, Alyssa L., Nomakuchi, Tomoki, Izumi, Kosuke, Kollman, Justin M.
Publicado 2023

REDD1-dependent GSK3β dephosphorylation promotes NF-κB activation and macrophage infiltration in the retina of diabetic mice

por Sunilkumar, Siddharth, VanCleave, Ashley M., McCurry, Christopher M., Toro, Allyson L., Stevens, Shaunaci A., Kimball, Scot R., Dennis, Michael D.
Publicado 2023

Repair of topoisomerase 1–induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding

por Shimizu, Naoto, Hamada, Yusaku, Morozumi, Ryosuke, Yamamoto, Junpei, Iwai, Shigenori, Sugiyama, Kei-ichi, Ide, Hiroshi, Tsuda, Masataka
Publicado 2023

Expression conditions and characterization of a novelly constructed lipoprotein intended as a vaccine to prevent human Haemophilus influenzae infections

por Kaur, Ravinder, Mangiafesto, Jill, Pryharski, Karin, Rasam, Sailee, Zagursky, Robert, Pichichero, Michael
Publicado 2023

Deficiency of the metabolic enzyme SCHAD in pancreatic β-cells promotes amino acid–sensitive hypoglycemia

por St-Louis, Johanna L., El Jellas, Khadija, Velasco, Kelly, Slipp, Brittany A., Hu, Jiang, Helgeland, Geir, Steine, Solrun J., De Jesus, Dario F., Kulkarni, Rohit N., Molven, Anders
Publicado 2023

NPC1 plays a role in the trafficking of specific cargo to melanosomes

por Rus, Alina Adriana, Militaru, Ioana V., Popa, Ioana, Munteanu, Cristian V.A., Sima, Livia Elena, Platt, Nick, Platt, Frances M., Petrescu, Ștefana M.
Publicado 2023

PTBP1 suppresses porcine epidemic diarrhea virus replication via inducing protein degradation and IFN production

por Qin, Wenzhen, Kong, Ning, Zhang, Yu, Wang, Chunmei, Dong, Sujie, Zhai, Huanjie, Zhai, Xueying, Yang, Xinyu, Ye, Chenqian, Ye, Manqing, Tong, Wu, Liu, Changlong, Yu, Lingxue, Zheng, Hao, Yu, Hai, Zhang, Wen, Lan, Daoliang, Tong, Guangzhi, Shan, Tongling
Publicado 2023

Evolutionary Quantitative Proteomics of Reproductive Protein Divergence in Drosophila

por Garlovsky, Martin D., Ahmed-Braimah, Yasir H.
Publicado 2023

Alternative fatty acid desaturation pathways revealed by deep profiling of total fatty acids in RAW 264.7 cell line

por Xia, Tian, Jin, Xue, Zhang, Donghui, Wang, Jitong, Jian, Ruijun, Yin, Hang, Xia, Yu
Publicado 2023

SREBP2 regulates the endothelial response to cytokines via direct transcriptional activation of KLF6

por Fowler, Joseph Wayne M., Boutagy, Nabil E., Zhang, Rong, Horikami, Daiki, Whalen, Michael B., Romanoski, Casey E., Sessa, William C.
Publicado 2023

A crystallin mutant cataract with mineral deposits

por Minogue, Peter J., Gao, Junyuan, Mathias, Richard T., Williams, James C., Bledsoe, Sharon B., Sommer, Andre J., Beyer, Eric C., Berthoud, Viviana M.
Publicado 2023

2-fluoro-1-methylpyridinium p-toluene sulfonate: a new LC-MS/MS derivatization reagent for vitamin D metabolites

por Alexandridou, Anastasia, Volmer, Dietrich A.
Publicado 2023

Differential roles for ACBD4 and ACBD5 in peroxisome–ER interactions and lipid metabolism

por Costello, Joseph L., Koster, Janet, Silva, Beatriz S.C., Worthy, Harley L., Schrader, Tina A., Hacker, Christian, Passmore, Josiah, Kuypers, Frans A., Waterham, Hans R., Schrader, Michael
Publicado 2023

Structure and function of a dual antagonist of the human growth hormone and prolactin receptors with site-specific PEG conjugates

por Basu, Reetobrata, Brody, Rich, Sandbhor, Uday, Kulkarni, Prateek, Davis, Emily, Swegan, Deborah, Caggiano, Lydia J., Brenya, Edward, Neggers, Sebastian, Kopchick, John J.
Publicado 2023

Deciphering Nucleic Acid Binding Proteome of Mouse Immune Organs Reveals Hub Proteins for Aging

por Wang, Huiyu, Zhang, Yan, Wang, Zeyuan, Zhang, Lu, Guo, Miao, Cao, Chengxi, Xiao, Hua
Publicado 2023

Palmitoylation-dependent control of JAK1 kinase signaling governs responses to neuropoietic cytokines and survival in DRG neurons

por Hernandez, Luiselys M., Montersino, Audrey, Niu, Jingwen, Guo, Shuchi, Faezov, Bulat, Sanders, Shaun S., Dunbrack, Roland L., Thomas, Gareth M.
Publicado 2023

On-demand utilization of phosphoribosyl pyrophosphate by downstream anabolic pathways

por Pinson, Benoît, Moenner, Michel, Saint-Marc, Christelle, Granger-Farbos, Alexandra, Daignan-Fornier, Bertrand
Publicado 2023

Synthetic receptor platform to identify loss-of-function single nucleotide variants and designed mutants in the death receptor Fas/CD95

por Minafra, Anna Rita, Rafii, Puyan, Mossner, Sofie, Bazgir, Farhad, Floss, Doreen M., Moll, Jens M., Scheller, Jürgen
Publicado 2023

Pathogenic Aβ production by heterozygous PSEN1 mutations is intrinsic to the mutant protein and not mediated by conformational hindrance of wild-type PSEN1

por Kurth, Vanessa, Ogorek, Isabella, Münch, Carolina, Lopez-Rios, Javier, Ousson, Solenne, Lehmann, Sandra, Nieweg, Katja, Roebroek, Anton J.M., Pietrzik, Claus U., Beher, Dirk, Weggen, Sascha
Publicado 2023

Proteome Landscapes of Human Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma

por Yi, Xiao, Zhu, Jiang, Liu, Wei, Peng, Li, Lu, Cong, Sun, Ping, Huang, Lingling, Nie, Xiu, Huang, Shi'ang, Guo, Tiannan, Zhu, Yi
Publicado 2023