Conformational dynamics of complement protease C1r inhibitor proteins from Lyme disease– and relapsing fever–causing spirochetes

por Roy, Sourav, Booth, Charles E., Powell-Pierce, Alexandra D., Schulz, Anna M., Skare, Jon T., Garcia, Brandon L.
Publicado 2023

Monocyte adhesive hyaluronan matrix induced by hyperglycemia in diabetic lung injuries

por Wang, Andrew Jun, Ren, Juan, Wang, Aimin, Hascall, Vincent C.
Publicado 2023

Putative malignant hyperthermia mutation Ca(V)1.1-R174W is insufficient to trigger a fulminant response to halothane or confer heat stress intolerance

por Feng, Wei, Lopez, Jose R., Antrobus, Shane, Zheng, Jing, Uryash, Arkady, Dong, Yao, Beqollari, Donald, Bannister, Roger A., Hopkins, Philip M., Beam, Kurt G., Allen, Paul D., Pessah, Isaac.N.
Publicado 2023

NAD metabolism modulates inflammation and mitochondria function in diabetic kidney disease

por Myakala, Komuraiah, Wang, Xiaoxin X., Shults, Nataliia V., Krawczyk, Ewa, Jones, Bryce A., Yang, Xiaoping, Rosenberg, Avi Z., Ginley, Brandon, Sarder, Pinaki, Brodsky, Leonid, Jang, Yura, Na, Chan Hyun, Qi, Yue, Zhang, Xu, Guha, Udayan, Wu, Ci, Bansal, Shivani, Ma, Junfeng, Cheema, Amrita, Albanese, Chris, Hirschey, Matthew D., Yoshida, Teruhiko, Kopp, Jeffrey B., Panov, Julia, Levi, Moshe
Publicado 2023

Kinetic and structural characterization of carboxyspermidine dehydrogenase of polyamine biosynthesis

por Lee, Danielle F., Atencio, Nicole, Bouchey, Shade, Shoemaker, Madeline R., Dodd, Joshua S., Satre, Meredith, Miller, Kenneth A., McFarlane, Jeffrey S.
Publicado 2023

Isethionate is an intermediate in the degradation of sulfoacetate by the human gut pathobiont Bilophila wadsworthia

por Liu, Xumei, Wei, Yifeng, Zhang, Jianing, Zhou, Yan, Du, Yunfei, Zhang, Yan
Publicado 2023

Computational redesign of cytochrome P450 CYP102A1 for highly stereoselective omeprazole hydroxylation by UniDesign

por Huang, Xiaoqiang, Sun, Yudong, Osawa, Yoichi, Chen, Y. Eugene, Zhang, Haoming
Publicado 2023

Nicotinamide N-methyltransferase mediates lipofibroblast–myofibroblast transition and apoptosis resistance

por Rehan, Mohammad, Deskin, Brian, Kurundkar, Ashish R., Yadav, Santosh, Matsunaga, Yasuka, Manges, Justin, Smith, Nia, Dsouza, Kevin G., Burow, Matthew E., Thannickal, Victor J.
Publicado 2023

An insulin-regulated arrestin domain protein controls hepatic glucagon action

por Dagdeviren, Sezin, Hoang, Megan F., Sarikhani, Mohsen, Meier, Vanessa, Benoit, Jake C., Okawa, Marinna C., Melnik, Veronika Y., Ricci-Blair, Elisabeth M., Foot, Natalie, Friedline, Randall H., Hu, Xiaodi, Tauer, Lauren A., Srinivasan, Arvind, Prigozhin, Maxim B., Shenoy, Sudha K., Kumar, Sharad, Kim, Jason K., Lee, Richard T.
Publicado 2023

Mitochondrial cytochrome P450 1B1 is involved in pregnenolone synthesis in human brain cells

por Lin, Yiqi Christina, Cheung, Garett, Zhang, Zeyu, Papadopoulos, Vassilios
Publicado 2023

UBA80 and UBA52 fine-tune RNF168-dependent histone ubiquitination and DNA repair

por Lee, Seong-Ok, Kelliher, Jessica L., Song, Wan, Tengler, Kyle, Sarkar, Aradhan, Dray, Eloise, Leung, Justin W.C.
Publicado 2023

Accelerated export of Dicer1 from lipid-challenged hepatocytes buffers cellular miRNA-122 levels and prevents cell death

por Bandyopadhyay, Diptankar, Basu, Sudarshana, Mukherjee, Ishita, Chakrabarti, Saikat, Chakrabarti, Partha, Mukherjee, Kamalika, Bhattacharyya, Suvendra N.
Publicado 2023

Developmental Pb exposure increases AD risk via altered intracellular Ca(2+) homeostasis in hiPSC-derived cortical neurons

por Xie, Junkai, Wu, Shichen, Szadowski, Hailey, Min, Sehong, Yang, Yang, Bowman, Aaron B., Rochet, Jean-Christophe, Freeman, Jennifer L., Yuan, Chongli
Publicado 2023

Unveiling the human nitroproteome: Protein tyrosine nitration in cell signaling and cancer

por Griswold-Prenner, Irene, Kashyap, Arun K., Mazhar, Sahar, Hall, Zach W., Fazelinia, Hossein, Ischiropoulos, Harry
Publicado 2023

Simultaneous isolation of hormone receptor–positive breast cancer organoids and fibroblasts reveals stroma-mediated resistance mechanisms

por Hogstrom, Jenny M., Cruz, Kayla A., Selfors, Laura M., Ward, Madelyn N., Mehta, Tejas S., Kanarek, Naama, Philips, Jordana, Dialani, Vandana, Wulf, Gerburg, Collins, Laura C., Patel, Jaymin M., Muranen, Taru
Publicado 2023

Respiratory complex I in mitochondrial membrane catalyzes oversized ubiquinones

por Ikunishi, Ryo, Otani, Ryohei, Masuya, Takahiro, Shinzawa-Itoh, Kyoko, Shiba, Tomoo, Murai, Masatoshi, Miyoshi, Hideto
Publicado 2023

Structural basis of bidirectional allostery across the heme in a cytochrome P450 enzyme

por Kumar, Amit, Estrada, D. Fernando
Publicado 2023

PhosphoDisco: A Toolkit for Co-regulated Phosphorylation Module Discovery in Phosphoproteomic Data

por Schraink, Tobias, Blumenberg, Lili, Hussey, Grant, George, Sabrina, Miller, Brecca, Mathew, Nithu, González-Robles, Tania J., Sviderskiy, Vladislav, Papagiannakopoulos, Thales, Possemato, Richard, Fenyö, David, Ruggles, Kelly V.
Publicado 2023

Heme binding to the SARS-CoV-2 spike glycoprotein

por Freeman, Samuel L., Oliveira, A. Sofia F., Gallio, Andrea E., Rosa, Annachiara, Simitakou, Maria K., Arthur, Christopher J., Mulholland, Adrian J., Cherepanov, Peter, Raven, Emma L.
Publicado 2023

A Peptidisc-Based Survey of the Plasma Membrane Proteome of a Mammalian Cell

por Zhao, Zhiyu, Khurana, Arshdeep, Antony, Frank, Young, John W., Hewton, Keeley G., Brough, Zora, Zhong, Tianshuang, Parker, Seth J., Duong van Hoa, Franck
Publicado 2023