Oxidative stress in the mitochondrial matrix underlies ischemia/reperfusion-induced mitochondrial instability

por Solhjoo, Soroosh, Liu, Ting, Sidor, Agnieszka, Lee, Dong I., O’Rourke, Brian, Steenbergen, Charles
Publicado 2022

A novel agonist with homobivalent single-domain antibodies that bind the FGF receptor 1 domain III functions as an FGF2 ligand

por Yonehara, Ryo, Kumachi, Shigefumi, Kashiwagi, Kenji, Wakabayashi-Nakao, Kanako, Motohashi, Maiko, Murakami, Taihei, Yanagisawa, Teruhiko, Arai, Hidenao, Murakami, Akikazu, Ueno, Yukio, Nemoto, Naoto, Tsuchiya, Masayuki
Publicado 2022

Neurodegeneration risk factor, EIF2AK3 (PERK), influences tau protein aggregation

por Park, Goonho, Xu, Ke, Chea, Leon, Kim, Kyle, Safarta, Lance, Song, Keon-Hyoung, Wu, Jian, Park, Soyoung, Min, Hyejung, Hiramatsu, Nobuhiko, Han, Jaeseok, Lin, Jonathan H.
Publicado 2022

Candidalysin: Connecting the pore forming mechanism of this virulence factor to its immunostimulatory properties

por Russell, Charles M., Rybak, Jennifer A., Miao, Jian, Peters, Brian M., Barrera, Francisco N.
Publicado 2022

Genetic Mimicry Analysis Reveals the Specific Lipases Targeted by the ANGPTL3-ANGPTL8 Complex and ANGPTL4

por Landfors, Fredrik, Chorell, Elin, Kersten, Sander
Publicado 2022

Smad2Δexon3 and Smad3 have distinct properties in signal transmission leading to TGF-β–induced cell motility

por Yokoyama, Takashi, Kuga, Takahito, Itoh, Yuka, Otake, Shigeo, Omata, Chiho, Saitoh, Masao, Miyazawa, Keiji
Publicado 2022

A simple, highly sensitive, and facile method to quantify ceramide at the plasma membrane

por Greene, Meaghan, Hernandez-Corbacho, Maria Jose, Ostermeyer-Fay, Anne G., Hannun, Yusuf A., Canals, Daniel
Publicado 2022

Oxonium Ion–Guided Optimization of Ion Mobility–Assisted Glycoproteomics on the timsTOF Pro

por Mukherjee, Soumya, Jankevics, Andris, Busch, Florian, Lubeck, Markus, Zou, Yang, Kruppa, Gary, Heck, Albert J.R., Scheltema, Richard A., Reiding, Karli R.
Publicado 2022

Difluoromethyl-1,3,4-oxadiazoles are slow-binding substrate analog inhibitors of histone deacetylase 6 with unprecedented isotype selectivity

por Cellupica, Edoardo, Caprini, Gianluca, Cordella, Paola, Cukier, Cyprian, Fossati, Gianluca, Marchini, Mattia, Rocchio, Ilaria, Sandrone, Giovanni, Vanoni, Maria Antonietta, Vergani, Barbara, Źrubek, Karol, Stevenazzi, Andrea, Steinkühler, Christian
Publicado 2022

The nematode α-catenin ortholog, HMP1, has an extended α-helix when bound to actin filaments

por Rangarajan, Erumbi S., Smith, Emmanuel W., Izard, Tina
Publicado 2022

How T118M peripheral myelin protein 22 predisposes humans to Charcot–Marie–Tooth disease

por Stefanski, Katherine M., Li, Geoffrey C., Marinko, Justin T., Carter, Bruce D., Samuels, David C., Sanders, Charles R.
Publicado 2022

Conformational interdomain flexibility in a bacterial α-isopropylmalate synthase is necessary for leucine biosynthesis

por Bai, Yu, Jiao, Wanting, Vörster, Jan, Parker, Emily J.
Publicado 2022

Measurements of Na(+)-occluded intermediates during the catalytic cycle of the Na(+)/K(+)-ATPase provide novel insights into the mechanism of Na(+) transport

por Faraj, Santiago E., Valsecchi, Wanda M., Ferreira-Gomes, Mariela, Centeno, Mercedes, Saint Martin, Elina Malén, Fedosova, Natalya U., Rossi, Juan Pablo FC., Montes, Mónica R., Rossi, Rolando C.
Publicado 2022

Charge neutralization of the active site glutamates does not limit substrate binding and transport by small multidrug resistance transporter EmrE

por Spreacker, Peyton J., Brousseau, Merissa, Hisao, Grant S., Soltani, Mohammad, Davis, James H., Henzler-Wildman, Katherine A.
Publicado 2022

Mechanistic insights into the nickel-dependent allosteric response of the Helicobacter pylori NikR transcription factor

por Baksh, Karina A., Augustine, Jerry, Sljoka, Adnan, Prosser, R. Scott, Zamble, Deborah B.
Publicado 2022

Temperature instability of a mutation at a multidomain junction in Na,K-ATPase isoform ATP1A3 (p.Arg756His) produces a fever-induced neurological syndrome

por Arystarkhova, Elena, Toustrup-Jensen, Mads S., Holm, Rikke, Ko, Jae-Kyun, Lee, Kyung Eun, Feschenko, Polina, Ozelius, Laurie J., Brashear, Allison, Vilsen, Bente, Sweadner, Kathleen J.
Publicado 2022

The N-terminal domain of human mitochondrial helicase Twinkle has DNA-binding activity crucial for supporting processive DNA synthesis by polymerase γ

por Johnson, Laura C., Singh, Anupam, Patel, Smita S.
Publicado 2022

MSstatsPTM: Statistical Relative Quantification of Posttranslational Modifications in Bottom-Up Mass Spectrometry-Based Proteomics

por Kohler, Devon, Tsai, Tsung-Heng, Verschueren, Erik, Huang, Ting, Hinkle, Trent, Phu, Lilian, Choi, Meena, Vitek, Olga
Publicado 2022

Regulation of cell size and Wee1 kinase by elevated levels of the cell cycle regulatory protein kinase Cdr2

por Berg, Rachel A., Moseley, James B.
Publicado 2022

TGF-β1 suppresses the T-cell response in teleost fish by initiating Smad3- and Foxp3-mediated transcriptional networks

por Zhang, Qian, Geng, Ming, Li, Kang, Gao, Haiyou, Jiao, Xinying, Ai, Kete, Wei, Xiumei, Yang, Jialong
Publicado 2022