Liver-specific FGFR4 knockdown in mice on an HFD increases bile acid synthesis and improves hepatic steatosis

por Moreau, Francois, Brunao, Bruna Brasil, Liu, Xiang-Yu, Tremblay, Frederic, Fitzgerald, Kevin, Avila-Pacheco, Julian, Clish, Clary, Kahn, Ronald C., Softic, Samir
Publicado 2022

Molecular dynamics simulations of the calmodulin-induced α-helix in the SK2 calcium-gated potassium ion channel

por Ramis, Rafael, Ballesteros, Óscar R., Muguruza-Montero, Arantza, M-Alicante, Sara, Núñez, Eider, Villarroel, Álvaro, Leonardo, Aritz, Bergara, Aitor
Publicado 2022

The First Pituitary Proteome Landscape From Matched Anterior and Posterior Lobes for a Better Understanding of the Pituitary Gland

por Banerjee, Arghya, Biswas, Deepatarup, Barpanda, Abhilash, Halder, Ankit, Sibal, Shamira, Kattimani, Rohit, Shah, Abhidha, Mahadevan, Anita, Goel, Atul, Srivastava, Sanjeeva
Publicado 2022

Mitochondria directly sense osmotic stress to trigger rapid metabolic remodeling via regulation of pyruvate dehydrogenase phosphorylation

por Ikizawa, Takeshi, Ikeda, Kazutaka, Arita, Makoto, Kitajima, Shojiro, Soga, Tomoyoshi, Ichijo, Hidenori, Naguro, Isao
Publicado 2022

Lysine Succinylation of VBS Contributes to Sclerotia Development and Aflatoxin Biosynthesis in Aspergillus flavus

por Wang, Yu, Yang, Mingkun, Ge, Feng, Jiang, Bin, Hu, Rui, Zhou, Xin, Yang, Yunhuang, Liu, Maili
Publicado 2022

The NTPase activity of the double FYVE domain–containing protein 1 regulates lipid droplet metabolism

por Ismail, V.A., Naismith, T., Kast, D.J.
Publicado 2022

Mass Spectrometry–Driven Discovery of Neuropeptides Mediating Nictation Behavior of Nematodes

por Cockx, Bram, Van Bael, Sven, Boelen, Rose, Vandewyer, Elke, Yang, Heeseung, Le, Tuan Anh, Dalzell, Johnathan J., Beets, Isabel, Ludwig, Christina, Lee, Junho, Temmerman, Liesbet
Publicado 2022

2-Hydroxypropyl-β-cyclodextrin mitigates pathological changes in a mouse model of retinal cholesterol dyshomeostasis

por El-Darzi, Nicole, Mast, Natalia, Hammer, Sandra S., Dorweiler, Tim F., Busik, Julia V., Pikuleva, Irina A.
Publicado 2022

Expanding and improving nanobody repertoires using a yeast display method: Targeting SARS-CoV-2

por Cross, Frederick R., Fridy, Peter C., Ketaren, Natalia E., Mast, Fred D., Li, Song, Olivier, J. Paul, Pecani, Kresti, Chait, Brian T., Aitchison, John D., Rout, Michael P.
Publicado 2023

Biochemical analysis of SARS-CoV-2 Nsp13 helicase implicated in COVID-19 and factors that regulate its catalytic functions

por Sommers, Joshua A., Loftus, Lorin N., Jones, Martin P., Lee, Rebecca A., Haren, Caitlin E., Dumm, Adaira J., Brosh, Robert M.
Publicado 2023

A solution structure analysis reveals a bent collagen triple helix in the complement activation recognition molecule mannan-binding lectin

por Iqbal, Hina, Fung, Ka Wai, Gor, Jayesh, Bishop, Anthony C., Makhatadze, George I., Brodsky, Barbara, Perkins, Stephen J.
Publicado 2022

Cryo-EM structure of the plant nitrate transporter AtCLCa reveals characteristics of the anion-binding site and the ATP-binding pocket

por He, Jin, Wang, Mingxing, Li, Shanshan, Chen, Long, Zhang, Kaiming, She, Ji
Publicado 2022

A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2

por Horton, John R., Zhou, Jujun, Chen, Qin, Zhang, Xing, Bedford, Mark T., Cheng, Xiaodong
Publicado 2022

Carnitine octanoyltransferase is important for the assimilation of exogenous acetyl-L-carnitine into acetyl-CoA in mammalian cells

por Hsu, Jake, Fatuzzo, Nina, Weng, Nielson, Michno, Wojciech, Dong, Wentao, Kienle, Maryline, Dai, Yuqin, Pasca, Anca, Abu-Remaileh, Monther, Rasgon, Natalie, Bigio, Benedetta, Nasca, Carla, Khosla, Chaitan
Publicado 2022

Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity

por Chen, Xiao-Ru, Poudel, Lokendra, Hong, Zebin, Johnen, Philipp, Katti, Sachin, Tripathi, Ashutosh, Nile, Aaron H., Green, Savana M., Khan, Danish, Schaaf, Gabriel, Bono, Fulvia, Bankaitis, Vytas A., Igumenova, Tatyana I.
Publicado 2023

Targeting peroxisomal fatty acid oxidation improves hepatic steatosis and insulin resistance in obese mice

por Yao, Haoya, Wang, Yaoqing, Zhang, Xiao, Li, Ping, Shang, Lin, Chen, Xiaocui, Zeng, Jia
Publicado 2022

Analysis of a degron-containing reporter protein GFP-CL1 reveals a role for SUMO1 in cytosolic protein quality control

por Wang, Wei, Lu, Jian, Yang, Wei-Chih, Spear, Eric D., Michaelis, Susan, Matunis, Michael J.
Publicado 2022

The Saccharomyces cerevisiae Yta7 ATPase hexamer contains a unique bromodomain tier that functions in nucleosome disassembly

por Wang, Feng, Feng, Xiang, He, Qing, Li, Hua, Li, Huilin
Publicado 2022

A liquid-to-solid phase transition of Cu/Zn superoxide dismutase 1 initiated by oxidation and disease mutation

por Gu, Siyu, Xu, Ming, Chen, Long, Shi, Xiangyan, Luo, Shi-Zhong
Publicado 2022

Two Trk/Ktr/HKT-type potassium transporters, TrkG and TrkH, perform distinct functions in Escherichia coli K-12

por Tanudjaja, Ellen, Hoshi, Naomi, Yamamoto, Kaneyoshi, Ihara, Kunio, Furuta, Tadaomi, Tsujii, Masaru, Ishimaru, Yasuhiro, Uozumi, Nobuyuki
Publicado 2022