Sphingosine kinase 1 is involved in triglyceride breakdown by maintaining lysosomal integrity in brown adipocytes

por Morishige, Jun-ichi, Yoshioka, Kazuaki, Nakata, Hiroki, Ishimaru, Kazuhiro, Nagata, Naoto, Tanaka, Tamotsu, Takuwa, Yoh, Ando, Hitoshi
Publicado 2023

Respiratory syncytial virus–approved mAb Palivizumab as ligand for anti-idiotype nanobody-based synthetic cytokine receptors

por Ettich, Julia, Wittich, Christoph, Moll, Jens M., Behnke, Kristina, Floss, Doreen M., Reiners, Jens, Christmann, Andreas, Lang, Philipp A., Smits, Sander H.J., Kolmar, Harald, Scheller, Jürgen
Publicado 2023

Metaorganismal choline metabolism shapes olfactory perception

por Massey, William J., Kay, Kristen E., Jaramillo, Thomas C., Horak, Anthony J., Cao, Shijie, Osborn, Lucas J., Banerjee, Rakhee, Mrdjen, Marko, Hamoudi, Michael K., Silver, Daniel J., Burrows, Amy C., Brown, Amanda L., Reizes, Ofer, Lathia, Justin D., Wang, Zeneng, Hazen, Stanley L., Brown, J. Mark
Publicado 2023

Hypoxic regulation of hypoxia inducible factor 1 alpha via antisense transcription

por Downes, Nicholas, Niskanen, Henri, Tomas Bosch, Vanesa, Taipale, Mari, Godiwala, Mehvash, Väänänen, Mari-Anna, Turunen, Tiia A., Aavik, Einari, Laham-Karam, Nihay, Ylä-Herttuala, Seppo, Kaikkonen, Minna U.
Publicado 2023

Hepatocyte-specific Wtap deficiency promotes hepatocellular carcinoma by activating GRB2–ERK depending on downregulation of proteasome-related genes

por Li, Xinzhi, Liu, Chunhong, Zhang, Zhimin, Li, Xueying, Yao, Zhicheng, Dong, Yanbin, Wang, Xin, Chen, Zheng
Publicado 2023

Exogenous oxygen is required for prostanoid induction under brain ischemia as evidence for a novel regulatory mechanism

por Seeger, Drew R., Schofield, Brennon, Besch, Derek, Golovko, Svetlana A., Kotha, Peddanna, Parmer, Meredith, Solaymani-Mohammadi, Shahram, Golovko, Mikhail Y.
Publicado 2023

Time-resolved study on signaling pathway of photoactivated adenylate cyclase and its nonlinear optical response

por Nakasone, Yusuke, Murakami, Hiroto, Tokonami, Shunrou, Oda, Takashi, Terazima, Masahide
Publicado 2023

Insulin-like growth factor binding protein-3 mediates hyperosmolar stress–induced mitophagy through the mechanistic target of rapamycin

por Stuard Sambhariya, Whitney, Trautmann, Ian J., Robertson, Danielle M.
Publicado 2023

Intralumenal docking of connexin 36 channels in the ER isolates mistrafficked protein

por Tetenborg, Stephan, Liss, Viktoria, Breitsprecher, Leonhard, Timonina, Ksenia, Kotova, Anna, Acevedo Harnecker, Alejandra Jesús, Yuan, Chunxu, Shihabeddin, Eyad, Ariakia, Fatemeh, Qin, Guoting, Chengzhi, Cai, Dedek, Karin, Zoidl, Georg, Hensel, Michael, O’Brien, John
Publicado 2023

Molecular mechanism for endo-type action of glycoside hydrolase family 55 endo-β-1,3-glucanase on β1-3/1-6-glucan

por Ota, Tomoya, Saburi, Wataru, Tagami, Takayoshi, Yu, Jian, Komba, Shiro, Jewell, Linda Elizabeth, Hsiang, Tom, Imai, Ryozo, Yao, Min, Mori, Haruhide
Publicado 2023

Ubiquitin-specific protease 11 structure in complex with an engineered substrate mimetic reveals a molecular feature for deubiquitination selectivity

por Maurer, Sigrun K., Mayer, Matthias P., Ward, Stephanie J., Boudjema, Sana, Halawa, Mohamed, Zhang, Jiatong, Caulton, Simon G., Emsley, Jonas, Dreveny, Ingrid
Publicado 2023

The preferential transport of NO(3)(−) by full-length Guillardia theta anion channelrhodopsin 1 is enhanced by its extended cytoplasmic domain

por Ohki, Yuya, Shinone, Tsukasa, Inoko, Sayo, Sudo, Miu, Demura, Makoto, Kikukawa, Takashi, Tsukamoto, Takashi
Publicado 2023

The mitochondrial amidoxime reducing component—from prodrug-activation mechanism to drug-metabolizing enzyme and onward to drug target

por Struwe, Michel A., Scheidig, Axel J., Clement, Bernd
Publicado 2023

Gαs is dispensable for β-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by β2-adrenergic receptor

por Burghi, Valeria, Paradis, Justine S., Officer, Adam, Adame-Garcia, Sendi Rafael, Wu, Xingyu, Matthees, Edda S.F., Barsi-Rhyne, Benjamin, Ramms, Dana J., Clubb, Lauren, Acosta, Monica, Tamayo, Pablo, Bouvier, Michel, Inoue, Asuka, von Zastrow, Mark, Hoffmann, Carsten, Gutkind, J. Silvio
Publicado 2023

BATF2 inhibits PD-L1 expression and regulates CD8+ T-cell infiltration in non–small cell lung cancer

por Liu, Junwei, Li, Jie, Tuo, Zhan, Hu, Weidong, Liu, Jun
Publicado 2023

Helicases in R-loop Formation and Resolution

por Yang, Shizhuo, Winstone, Lacey, Mondal, Sohaumn, Wu, Yuliang
Publicado 2023

8-Oxoguanine DNA glycosylase 1 selectively modulates ROS-responsive NF-κB targets through recruitment of MSK1 and phosphorylation of RelA/p65 at Ser276

por Xue, Yaoyao, Li, Chunshuang, Deng, Shihua, Chen, Xin, Han, Jinling, Zheng, Xu, Tian, Miaomiao, Hao, Wenjing, Pan, Lang, Boldogh, Istvan, Ba, Xueqing, Wang, Ruoxi
Publicado 2023

A multiple-oscillator mechanism underlies antigen-induced Ca(2+) oscillations in Jurkat T-cells

por Benson, J. Cory, Romito, Olivier, Abdelnaby, Ahmed Emam, Xin, Ping, Pathak, Trayambak, Weir, Sierra E., Kirk, Vivien, Castaneda, Francisco, Yoast, Ryan E., Emrich, Scott M., Tang, Priscilla W., Yule, David I., Hempel, Nadine, Potier-Cartereau, Marie, Sneyd, James, Trebak, Mohamed
Publicado 2023

HPIP and RUFY3 are noncanonical guanine nucleotide exchange factors of Rab5 to regulate endocytosis-coupled focal adhesion turnover

por Khumukcham, Saratchandra Singh, Penugurti, Vasudevarao, Bugide, Suresh, Dwivedi, Anju, Kumari, Anita, Kesavan, P.S., Kalali, Sruchytha, Mishra, Yasaswi Gayatri, Ramesh, Vakkalagadda A., Nagarajaram, Hampapathalu A., Mazumder, Aprotim, Manavathi, Bramanandam
Publicado 2023

Pseudomonas aeruginosa AlgF is a protein–protein interaction mediator required for acetylation of the alginate exopolysaccharide

por Low, Kristin E., Gheorghita, Andreea A., Tammam, Stephanie D., Whitfield, Gregory B., Li, Yancheng E., Riley, Laura M., Weadge, Joel T., Caldwell, Shane J., Chong, P. Andrew, Walvoort, Marthe T.C., Kitova, Elena N., Klassen, John S., Codée, Jeroen D.C., Howell, P. Lynne
Publicado 2023