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1por Vasudeva, Rhythm, Challa, Abhiram, Chaaban, Nourhan, Shah, Hamna, Brumfield, Elisha, Duran, Brent, Vindhyal, MohinderEnlace del recurso
Publicado 2023
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2por Plaza, David Fernando, Lin, Chia-Wei, van der Velden, Niels Sebastiaan Johannes, Aebi, Markus, Künzler, MarkusEnlace del recurso
Publicado 2014
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3por Zámocký, Marcel, Tafer, Hakim, Chovanová, Katarína, Lopandic, Ksenija, Kamlárová, Anna, Obinger, Christian“…We show that this filamentous fungus is closely related but not identical to Chaetomium globosum and Chaetomium elatum. …”
Publicado 2016
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4por Beenakker, Thomas J. M., Wander, Dennis P. A., Offen, Wendy A., Artola, Marta, Raich, Lluís, Ferraz, Maria J., Li, Kah-Yee, Houben, Judith H. P. M., van Rijssel, Erwin R., Hansen, Thomas, van der Marel, Gijsbert A., Codée, Jeroen D. C., Aerts, Johannes M. F. G., Rovira, Carme, Davies, Gideon J., Overkleeft, Herman S.“…Ab initio metadynamics simulations of the conformational free energy landscape for the cyclopropyl inhibitors show a strong bias for the (4)H(3) conformation, and carba-cyclophellitol, with an N-(4-azidobutyl)carboxamide moiety, proved to be a potent inhibitor (K(i) = 8.2 nM) of the Thermotoga maritimaTmGH1 β-glucosidase. 3-D structural analysis and comparison with unreacted epoxides show that this compound indeed binds in the (4)H(3) conformation, suggesting that conformational strain induced through a cyclopropyl unit may add to the armory of tight-binding inhibitor designs.…”
Publicado 2017
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5“…This review summarizes those cannabinoids and cannabis-informed molecules and preparations (CIMPs) that show promise as microbicidal agents, with a particular focus on the most recent developments. …”
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6“…Helminth parasites such as the nematode Heligmosomoides polygyrus strongly inhibit T helper type 2 (Th2) allergy, as well as colitis and autoimmunity. Here, we show that the soluble excretory/secretory products of H. polygyrus (HES) potently suppress inflammation induced by allergens from the common fungus Alternaria alternata. …”
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7por Matthews, Stephen P., McMillan, Sarah J., Colbert, Jeff D., Lawrence, Rachel A., Watts, Colin“…Paradoxically, eosinophils also express an armory of granule-localized toxins and hydrolases believed to contribute to pathology in inflammatory disease. …”
Publicado 2016
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8“…Jobelyn (JB) is a potent antioxidant African polyherbal formulation with active components that have been acclaimed to show neuroprotection. This investigation was carried out to evaluate whether JB has anti-amnesic and antioxidant activities. …”
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9“…Multicolor composite image showed circumscribed perifoveal arcuate area of darkening, and infrared reflectance showed speckled hyperreflecetance in both eyes. …”
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10por Hung, Sophia, Kasperkowitz, Amelie, Kurz, Florian, Dreher, Liane, Diessner, Joachim, Ibrahim, Eslam S., Schwarz, Stefan, Ohlsen, Knut, Hertlein, Tobias“…Though Staphylococcus aureus infects and colonizes a variety of species, it has nonetheless become one of the most successful human pathogens of our time with a wide armory of human-adapted virulence factors. Humanized mice showed increased vulnerability to S. aureus compared to wild type mice in a variety of clinically relevant disease models. …”
Publicado 2023
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11por Sabbatinelli, Jacopo, Giuliani, Angelica, Matacchione, Giulia, Latini, Silvia, Laprovitera, Noemi, Pomponio, Giovanni, Ferrarini, Alessia, Svegliati Baroni, Silvia, Pavani, Marianna, Moretti, Marco, Gabrielli, Armando, Procopio, Antonio Domenico, Ferracin, Manuela, Bonafè, Massimiliano, Olivieri, Fabiola“…Among non-responders, those with the lowest serum levels of miR-146a-5p experienced the most adverse outcome (p = 0.008). Our data show that a blood-based biomarker, such as miR-146a-5p, can provide clues about the molecular link between inflammaging and COVID-19 clinical course, thus allowing to better understand the use of biologic drug armory against this worldwide health threat.…”
Publicado 2021
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12por Satala, Dorota, Gonzalez-Gonzalez, Miriam, Smolarz, Magdalena, Surowiec, Magdalena, Kulig, Kamila, Wronowska, Ewelina, Zawrotniak, Marcin, Kozik, Andrzej, Rapala-Kozik, Maria, Karkowska-Kuleta, Justyna“…The non-protein biofilm-composing factors also show dynamic variability upon the contact with bacteria, and their biosynthesis processes could be involved in the stability of mixed biofilms. …”
Publicado 2022
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13por Khayyat, Ahdab N., Abbas, Hisham A., Khayat, Maan T., Shaldam, Moataz A., Askoura, Momen, Asfour, Hani Z., Khafagy, El-Sayed, Abu Lila, Amr S., Allam, Ahmed N., Hegazy, Wael A. H.“…S. marcescens has developed considerable resistance to different antibiotics and is equipped with an armory of virulence factors. These virulence factors are regulated in S. marcescens by an intercellular communication system termed quorum sensing (QS). …”
Publicado 2021
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14por Jouda, Jean-Bosco, Tamokou, Jean-de-Dieu, Mbazoa, Céline Djama, Douala-Meli, Clovis, Sarkar, Prodipta, Bag, Prasanta Kumar, Wandji, Jean“…BACKGROUND: The continuous emergence of multidrug-resistant (MDR) bacteria drastically reduced the efficacy of our antibiotic armory and consequently, increased the frequency of therapeutic failure. …”
Publicado 2016
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15Pluchea lanceolata protects against Benzo(a) pyrene induced renal toxicity and loss of DNA integrity“…In conclusion, the present findings strongly support the antioxidant efficacy of PL, possibly by modulation of antioxidant armory.…”
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16por Artan, Murat, Barratt, Stephen, Flynn, Sean M., Begum, Farida, Skehel, Mark, Nicolas, Armel, de Bono, Mario“…To probe the method's sensitivity, we expressed TurboID exclusively in the two AFD neurons and showed that the protocol could identify known and previously unknown proteins expressed selectively in AFD. …”
Publicado 2021
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17“…Antisera from Lip-WCAgs-immunized mice showed the utmost bactericidal activity and potently inhibited the biofilm formation by A. baumannii. …”
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18por Wang, Peili, Zhang, Jiaxiang, Chen, Yanfei, Zhong, Haoran, Wang, Heng, Li, Jianji, Zhu, Guoqiang, Xia, Pengpeng, Cui, Luying, Li, Jun, Dong, Junsheng, Gao, Qingqing, Meng, Xia“…Meningitis did not occur in APEC ΔclbH-infected mice in vivo, who showed fewer clinical symptoms and fewer lesions on radiological and histopathological analyses. …”
Publicado 2021
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19por Dölling, Maximilian, Eckstein, Markus, Singh, Jeeshan, Schauer, Christine, Schoen, Janina, Shan, Xiaomei, Bozec, Aline, Knopf, Jasmin, Schett, Georg, Muñoz, Luis E., Herrmann, Martin“…Phagocytosis, degranulation, and neutrophil extracellular traps (NETs) formation build the armory of neutrophils for the first line of defense against invading pathogens. …”
Publicado 2022
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20“…In this sense, the Institute Curie- Université Pierre et Marie Curie (Paris 6) designed peptides in order to disturb Ras/Raf interaction which showed pro-apoptotic properties. These peptides were patented as WO2015001045 A2 (PCT/EP2014/064243)5. …”
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