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541“…The recommended single agent dose of losoxantrone is 50 mg m(−2) every 3 weeks. …”
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542“…These considerations have prompted research into new platinum agents, such as the trinuclear platinum agent BBR3464, the platinum complex ZD0473 and oxaliplatin. …”
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543“…We devised an experimental tumour metastasis model that allowed manipulation of primary tumour vascularity with differential exposure of the primary and metastatic tumour site to angiogenic agents. We used this model to assess the effects of local and systemic increases in the level of the angiogenic agent basic fibroblast growth factor on metastasis. …”
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544“…The tumour extracellular matrix acts as a barrier to the delivery of therapeutic agents. To test the hypothesis that extracellular matrix composition governs the penetration rate of macromolecules in tumour tissue, we measured the diffusion coefficient of nonspecific IgG in three rhabdomyosarcoma subclones growing as multicellular spheroids in vitro or as subcutaneous tumours in dorsal windows in vivo. …”
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545
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546por Imoto, S, Kawamura, K, Tokumine, Y, Araki, N, Akita, S, Nishimura, C, Inaba, H, Saigo, K, Mabuchi, O, Okazaki, HEnlace del recurso
Publicado 2010
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547“…Combination therapy may be considered in individual patients. Second line agents include ifosfamide, dacarbazine, trabectedin and the combination of gemcitabine + docetaxel. …”
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548
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549por Goodnough, L. T., Maniatis, A., Earnshaw, P., Benoni, G., Beris, P., Bisbe, E., Fergusson, D. A., Gombotz, H., Habler, O., Monk, T. G., Ozier, Y., Slappendel, R., Szpalski, M.Enlace del recurso
Publicado 2011
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550
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551
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552por Biek, Roman, O'Hare, Anthony, Wright, David, Mallon, Tom, McCormick, Carl, Orton, Richard J., McDowell, Stanley, Trewby, Hannah, Skuce, Robin A., Kao, Rowland R.“…It is likely to be particularly useful for studying the transmission dynamics of an observed epidemic involving a largely unsampled ‘reservoir’ host, as for bovine tuberculosis (bTB) in British and Irish cattle and badgers. BTB is caused by Mycobacterium bovis, a member of the M. tuberculosis complex that also includes the aetiological agent for human TB. …”
Publicado 2012
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553
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554“…Interventions showing promise in this disease include dexamethasone implants, immunomodulatory drugs and anti-vascular endothelial growth-factor agents. When macular edema has become refractory after multiple interventions, pars plana vitrectomy could be considered. …”
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555
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556
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557
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558por Waheed, A, Ludtmann, M H R, Pakes, N, Robery, S, Kuspa, A, Dinh, C, Baines, D, Williams, R S B, Carew, M AEnlace del recurso
Publicado 2014
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559
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560por Kemp, K, Gordon, D, Wraith, D C, Mallam, E, Hartfield, E, Uney, J, Wilkins, A, Scolding, NEnlace del recurso
Publicado 2011
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