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Mostrando 941 - 960 Resultados de 1,135 Para Buscar 'Ashenden: OR the British Agent*', tiempo de consulta: 0.28s Limitar resultados
  1. 941
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    P33 Using the Australian National Antimicrobial Prescribing Survey (NAPS) portal to undertake an annual point prevalence survey (PPS)
  2. 942
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    Activity of ceftolozane/tazobactam and imipenem/relebactam against clinical isolates of Enterobacterales and Pseudomonas aeruginosa collected in central and northern Europe (Belgium, Norway, Sweden, Switzerland)—SMART 2017–21
  3. 943
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    Real-world evidence for secukinumab in UK patients with psoriatic arthritis or radiographic axial spondyloarthritis: interim 2-year analysis from SERENA
  4. 944
    “…Mice bearing Glasgow osteosarcoma (GOS) received single agent irinotecan (50 or 60 mg kg(−1) per day) or oxaliplatin (4 or 5.25 mg kg(−1) per day) at one of six dosing times expressed in hours after light onset (3, 7, 11, 15, 19 or 23 hours after light onset). …”
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    Circadian optimisation of irinotecan and oxaliplatin efficacy in mice with Glasgow osteosarcoma
  5. 945
    “…Yet, 20 to 30% of the treated tumours do not respond. Therefore agents that synergise with tumour necrosis factor alpha must be investigated. …”
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    Isolated limb perfusion with actinomycin D and TNF-alpha results in improved tumour response in soft-tissue sarcoma-bearing rats but is accompanied by severe local toxicity
  6. 946
    “…DNA mismatch repair-deficient cells have been reported to be resistant to many chemotherapeutic agents and to radiotherapy, and to have the potential of rapidly acquiring additional mutations leading to tumour progression. …”
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    Photodynamic therapy of DNA mismatch repair-deficient and -proficient tumour cells
  7. 947
    por Rivory, L P, Slaviero, K A, Clarke, S J
    Publicado 2002
    “…Inflammatory disease states (infection, arthritis) are associated with reduced drug oxidation by the cytochrome P450 3A system. Many chemotherapy agents are metabolised through this pathway, and disease may therefore influence inter-individual differences in drug pharmacokinetics. …”
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    Hepatic cytochrome P450 3A drug metabolism is reduced in cancer patients who have an acute-phase response
  8. 948
    “…Irinotecan (CPT-11) is an anticancer agent for the treatment of colon cancer. CPT-11 can be considered as a prodrug, since it needs to be activated into the toxic drug SN-38 by the enzyme carboxylesterase. …”
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    Secreted and tumour targeted human carboxylesterase for activation of irinotecan
  9. 949
    “…The systemic inflammatory composite score (consists of body temperature, fatigue, S-CRP, interleukin-6 (S-IL-6), S-IL-8, and tumour necrosis factor-α (S-TNFα) levels) was calculated in a cross-sectional one-cycle study involving 60 colorectal cancer patients treated with single-agent raltitrexed, raltitrexed and carmofur, or 5-fluorouracil-based chemotherapy (n=20 in each group). …”
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    Raltitrexed treatment promotes systemic inflammatory reaction in patients with colorectal carcinoma
  10. 950
    “…The findings support further phase II evaluation of DaunoXome alone and in combination with other standard non-anthracycline cytotoxic or novel targeted agents. Although the dose-limiting toxicity for DaunoXome was febrile neutropenia at 120 mg m(2), we would recommend this dose for further evaluation, as the febrile neutropenia occurred after four or more cycles in three of the four episodes seen, was short lived and uncomplicated. …”
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    A phase I dose-escalating study of DaunoXome, liposomal daunorubicin, in metastatic breast cancer
  11. 951
    “…The role of new cytotoxic agents like gemcitabine has not yet been proven in the neoadjuvant settings. …”
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    Gemcitabine and cisplatin in a multimodality treatment for locally advanced non-small cell lung cancer
  12. 952
    “…An important determinant of cellular resistance to chemotherapeutic O(6)-alkylating agents, which comprise methylating and chloroethylating agents, is the ability of cells to repair alkylation damage at the O(6)-position of guanine in DNA. …”
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    Heterogeneity of O(6)-alkylguanine DNA-alkyltransferase expression in human breast tumours
  13. 953
    “…Our results suggest that angiopoietin-1 is an important mediator of angiogenesis and vascular permeability and thus could theoretically serve as an anti-neoplastic agent for patients with carcinomatosis from colorectal cancer. …”
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    Angiopoietin-1 inhibits tumour growth and ascites formation in a murine model of peritoneal carcinomatosis
  14. 954
    “…Previously, a range of detoxification agents have been prescribed without a clear evidence base to recommend a drug of choice. …”
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    The Leeds Evaluation of Efficacy of Detoxification Study (LEEDS) prisons project: a randomised controlled trial comparing dihydrocodeine and buprenorphine for opiate detoxification
  15. 955
    “…In the single agent group 153 (22%) of 691 patients conceived early. …”
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    The effect of early pregnancy following chemotherapy on disease relapse and foetal outcome in women treated for gestational trophoblastic tumours
  16. 956
    “…METHODS: Overall, 84 advanced BTC patients were randomised to either cisplatin 25 mg m(−2) plus gemcitabine 1000 mg m(−2) on days 1, 8 of a 21-day cycle (GC-arm), or single-agent gemcitabine 1000 mg m(−2) on days 1, 8 and 15 of a 28-day cycle (G-arm). …”
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    Gemcitabine alone or in combination with cisplatin in patients with biliary tract cancer: a comparative multicentre study in Japan
  17. 957
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    Occupational Exposure and New-onset Asthma in a Population-based Study in Northern Europe (RHINE)
  18. 958
    “…OBJECTIVES: To evaluate treatment with the peptide-based agent, Lupuzor, in a double-blind, randomised, placebo-controlled study of patients with systemic lupus erythematosus. …”
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    Lupuzor/P140 peptide in patients with systemic lupus erythematosus: a randomised, double-blind, placebo-controlled phase IIb clinical trial
  19. 959
    “…Similarly almost one in five, combined heavy drinking with anti-coagulants/anti-platelets and cardiovascular agents, with 16% combining heavy drinking with CNS agents. …”
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    Potential for alcohol and drug interactions in older adults: evidence from the Irish longitudinal study on ageing
  20. 960
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    LP-925219 maximizes urinary glucose excretion in mice by inhibiting both renal SGLT1 and SGLT2
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