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  1. 601
    “…The results suggest that Trigger Loop folding in the pre-translocated state may serve to reduce backtracking of the elongation complex. Overall, we propose that translocation may be a limiting and highly regulated step of RNA synthesis.…”
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    Tagetitoxin inhibits transcription by stabilizing pre-translocated state of the elongation complex
  2. 602
    “…Furthermore, other processes central to traditional AI models (error correction and backtracking) appear to be of less importance for human players.…”
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    Crossword expertise as recognitional decision making: an artificial intelligence approach
  3. 603
    “…To cast light onto the alternative active or backtracking states of RNA polymerase II, we have quantitatively mapped active RNA polymerases at a high resolution following a new biotin-based genomic run-on (BioGRO) technique. …”
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    Chromatin-dependent regulation of RNA polymerases II and III activity throughout the transcription cycle
  4. 604
    “…Since misincorporation leads to a strong pause of transcription due to backtracking, our findings indicate that misincorporation could be a major source of transcriptional pausing and lead to conflicts with other RNA polymerases and replication in bacteria and eukaryotes. …”
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    Misincorporation by RNA polymerase is a major source of transcription pausing in vivo
  5. 605
    “…The pausing depends on σ(38) contacts with the DNA template and RNAP core enzyme and results in formation of backtracked transcription elongation complexes, which can be reactivated by Gre factors that induce RNA cleavage by RNAP. …”
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    σ(38)-dependent promoter-proximal pausing by bacterial RNA polymerase
  6. 606
    “…Single-cell HSPC index-sorting and clonogenic assays show that (1) all somatic mutations can be backtracked to the phenotypic HSC compartment, with RAS-pathway mutations as a “first hit,” (2) mutations are acquired with both linear and branching patterns of clonal evolution, and (3) mutant HSPCs are present after allogeneic HSC transplant before molecular/clinical evidence of relapse. …”
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    Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia
  7. 607
    “…Methods: A retrospective cohort study was conducted, with 1592 child maltreatment cases and 6368 comparison cohort (1:4) matched for gender, age, and index year, from the Longitudinal Generation Tracking Database (LGTD2000) sampled from Taiwan National Health Insurance Research Database (NHIRD) in 2000, backtracking between 2000–2015 in Taiwan. The stratified Cox regression model was used to compare the risk of developing a mental illness and poor prognosis during the 15 years of follow-up. …”
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    Exposure of Child Maltreatment Leads to a Risk of Mental Illness and Poor Prognosis in Taiwan: A Nationwide Cohort Study from 2000 to 2015
  8. 608
    “…We propose that stalled RNAP is dislodged from DNA by RapA via backtracking in a supercoiling- and torque-dependent manner, suggesting that RapA’s activity on transcribing RNAP in vivo is responsible for resolving conflicts between converging polymerase molecular motors.…”
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    On the stability of stalled RNA polymerase and its removal by RapA
  9. 609
    por Gallitto, Matthew, Zhang, Zhiguo
    Publicado 2023
    “…They further discovered that EXO-mediated polymerase backtracking impedes forward movement of the enzyme when POPS is defective, revealing a novel interplay between the EXO domain and POPS of Pol2 for efficient DNA synthesis. …”
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    The evolving tale of Pol2 function
  10. 610
    “…In addition, the HMC group evoked smaller alpha ERD during the initial retrieval and the backtracking process in the RAT, associated with cognitive control adaptability. …”
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    Alpha ERS-ERD Pattern during Divergent and Convergent Thinking Depends on Individual Differences on Metacontrol
  11. 611
    por Cao, Yiqun, Jiang, Tao, Girke, Thomas
    Publicado 2008
    “…Results: In this article, a new backtracking algorithm for MCS is proposed and compared to global similarity measurements. …”
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    A maximum common substructure-based algorithm for searching and predicting drug-like compounds
  12. 612
    por Shimizu, Kana, Tsuda, Koji
    Publicado 2011
    “…Compared to existing methods based on single k-mers, our method is more effective in reducing the number of edit distance calculations. In comparison to backtracking methods such as BWA, our method is much faster in finding remote matches, scaling easily to tens of millions of sequences. …”
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    SlideSort: all pairs similarity search for short reads
  13. 613
    “…Transcription factor IIS (TFIIS) is a protein known for catalyzing the cleavage reaction of the 3′-end of backtracked RNA transcript, allowing RNA polymerase II (Pol II) to reactivate the transcription process from the arrested state. …”
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    Molecular Dynamics Simulation Study of Conformational Changes of Transcription Factor TFIIS during RNA Polymerase II Transcriptional Arrest and Reactivation
  14. 614
    “…Several adult valve diseases can be backtracked to abnormal valve development, making it imperative to completely understand the process and regulation of heart valve development. …”
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    Altered Hemodynamics in the Embryonic Heart Affects Outflow Valve Development
  15. 615
    “…The problem is NP-hard and is traditionally solved by backtracking algorithms. RESULTS: We have designed a new algorithm for RNA motif search and implemented a new motif search tool RNArobo. …”
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    RNA motif search with data-driven element ordering
  16. 616
    “…Furthermore, we find that encapsulation reduces backtracking that arises from the destabilisation of nucleation sites, smoothing the free energy landscape. …”
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    Knotting and unknotting proteins in the chaperonin cage: Effects of the excluded volume
  17. 617
    Publicado 2018
    “…The proposed method achieves a role identification accuracy of 84% and a backtracking role identification of 79% for obscured roles using interaction and appearance features on real ICU data. …”
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    Healthcare Event and Activity Logging
  18. 618
    “…Additionally an animation is generated showing how the most significant overlap is reached by backtracking. We demonstrate the improved performance of DynaVenn over an arbitrary cut-off approach on an Alzheimer’s Disease biomarker set. …”
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    DynaVenn: web-based computation of the most significant overlap between ordered sets
  19. 619
    “…Thus, simplifying the time schedule of the induction protocol could be effective in increasing the adherence to SCIT. METHODS: We backtracked the SCIT renewal orders, thanks to the cooperation of the manufacturing company, and we compared the long-term adherence of 152 patients, who were prescribed with an abbreviated build-up schedule (4 injections, allergoid) with that of 302 patients treated with the same product, but with the traditional build-up protocol (7 injections). …”
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    Adherence to Allergen Subcutaneous Immunotherapy is Increased by a Shortened Build-Up Phase: A Retrospective Study
  20. 620
    por Rashkova, Ekaterina R.
    Publicado 2020
    “…One such reaction—the adopted strengthening of power for Hungary’s Prime Minister—has prompted an international outcry and re-heated the debate of the democratic backtracking of some of the new EU member-states. Analyzing the process of European Enlargement and the changing sentiments about European Integration in a number of East European countries, this symposium brings to the fore important questions about the relationship between Eastern and Western Europe. …”
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    The future of Europe and the role of Eastern Europe in its past, present and future
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