Distinct clinical and immunological profiles of patients with evidence of SARS-CoV-2 infection in sub-Saharan Africa

por Morton, Ben, Barnes, Kayla G., Anscombe, Catherine, Jere, Khuzwayo, Matambo, Prisca, Mandolo, Jonathan, Kamng’ona, Raphael, Brown, Comfort, Nyirenda, James, Phiri, Tamara, Banda, Ndaziona P., Van Der Veer, Charlotte, Mndolo, Kwazizira S., Mponda, Kelvin, Rylance, Jamie, Phiri, Chimota, Mallewa, Jane, Nyirenda, Mulinda, Katha, Grace, Kambiya, Paul, Jafali, James, Mwandumba, Henry C., Gordon, Stephen B., Cornick, Jennifer, Jambo, Kondwani C.
Publicado 2021

Development and validation of a risk prediction model of preterm birth for women with preterm labour symptoms (the QUIDS study): A prospective cohort study and individual participa...

por Stock, Sarah J., Horne, Margaret, Bruijn, Merel, White, Helen, Boyd, Kathleen A., Heggie, Robert, Wotherspoon, Lisa, Aucott, Lorna, Morris, Rachel K., Dorling, Jon, Jackson, Lesley, Chandiramani, Manju, David, Anna L., Khalil, Asma, Shennan, Andrew, van Baaren, Gert-Jan, Hodgetts-Morton, Victoria, Lavender, Tina, Schuit, Ewoud, Harper-Clarke, Susan, Mol, Ben W., Riley, Richard D., Norman, Jane E., Norrie, John
Publicado 2021

Different clinical features in Malawian outpatients presenting with COVID-19 prior to and during Omicron variant dominance: A prospective observational study

por Chibwana, Marah G., Thole, Herbert W., Anscombe, Cat, Ashton, Philip M., Green, Edward, Barnes, Kayla G., Cornick, Jen, Turner, Ann, Witte, Desiree, Nthala, Sharon, Thom, Chikondi, Kanyandula, Felistas, Ainani, Anna, Mtike, Natasha, Tambala, Hope, N’goma, Veronica, Mwafulirwa, Dorah, Asima, Erick, Morton, Ben, Gmeiner, Markus, Gundah, Zaziwe, Kawalazira, Gift, French, Neil, Feasey, Nicholas, Heyderman, Robert S., Swarthout, Todd D., Jambo, Kondwani C.
Publicado 2023

Changes in COVID-19-related mortality across key demographic and clinical subgroups in England from 2020 to 2022: a retrospective cohort study using the OpenSAFELY platform

por Nab, Linda, Parker, Edward P K, Andrews, Colm D, Hulme, William J, Fisher, Louis, Morley, Jessica, Mehrkar, Amir, MacKenna, Brian, Inglesby, Peter, Morton, Caroline E, Bacon, Sebastian C J, Hickman, George, Evans, David, Ward, Tom, Smith, Rebecca M, Davy, Simon, Dillingham, Iain, Maude, Steven, Butler-Cole, Ben F C, O’Dwyer, Thomas, Stables, Catherine L, Bridges, Lucy, Bates, Christopher, Cockburn, Jonathan, Parry, John, Hester, Frank, Harper, Sam, Zheng, Bang, Williamson, Elizabeth J, Eggo, Rosalind M, Evans, Stephen J W, Goldacre, Ben, Tomlinson, Laurie A, Walker, Alex J
Publicado 2023

Effect of 13-valent pneumococcal conjugate vaccine on experimental carriage of Streptococcus pneumoniae serotype 6B in Blantyre, Malawi: a randomised controlled trial and controlle...

por Dula, Dingase, Morton, Ben, Chikaonda, Tarsizio, Chirwa, Anthony E, Nsomba, Edna, Nkhoma, Vitumbiko, Ngoliwa, Clara, Sichone, Simon, Galafa, Bridgette, Tembo, Godwin, Chaponda, Mphatso, Toto, Neema, Kamng'ona, Raphael, Makhaza, Lumbani, Muyaya, Alfred, Thole, Faith, Kudowa, Evaristar, Howard, Ashleigh, Kenny-Nyazika, Tinashe, Ndaferankhande, John, Mkandawire, Christopher, Chiwala, Gift, Chimgoneko, Lorensio, Banda, Ndaziona P K, Rylance, Jamie, Ferreira, Daniela, Jambo, Kondwani, Henrion, Marc Y R, Gordon, Stephen B
Publicado 2023

HIV infection and COVID-19 death: a population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform

por Bhaskaran, Krishnan, Rentsch, Christopher T, MacKenna, Brian, Schultze, Anna, Mehrkar, Amir, Bates, Chris J, Eggo, Rosalind M, Morton, Caroline E, Bacon, Sebastian C J, Inglesby, Peter, Douglas, Ian J, Walker, Alex J, McDonald, Helen I, Cockburn, Jonathan, Williamson, Elizabeth J, Evans, David, Forbes, Harriet J, Curtis, Helen J, Hulme, William J, Parry, John, Hester, Frank, Harper, Sam, Evans, Stephen J W, Smeeth, Liam, Goldacre, Ben
Publicado 2021

Factors associated with deaths due to COVID-19 versus other causes: population-based cohort analysis of UK primary care data and linked national death registrations within the Open...

por Bhaskaran, Krishnan, Bacon, Sebastian, Evans, Stephen JW, Bates, Chris J, Rentsch, Christopher T, MacKenna, Brian, Tomlinson, Laurie, Walker, Alex J, Schultze, Anna, Morton, Caroline E, Grint, Daniel, Mehrkar, Amir, Eggo, Rosalind M, Inglesby, Peter, Douglas, Ian J, McDonald, Helen I, Cockburn, Jonathan, Williamson, Elizabeth J, Evans, David, Curtis, Helen J, Hulme, William J, Parry, John, Hester, Frank, Harper, Sam, Spiegelhalter, David, Smeeth, Liam, Goldacre, Ben
Publicado 2021

OpenSAFELY: impact of national guidance on switching anticoagulant therapy during COVID-19 pandemic

por Curtis, Helen J, MacKenna, Brian, Walker, Alex J, Croker, Richard, Mehrkar, Amir, Morton, Caroline, Bacon, Seb, Hickman, George, Inglesby, Peter, Bates, Chris, Evans, David, Ward, Tom, Cockburn, Jonathan, Davy, Simon, Bhaskaran, Krishnan, Schultze, Anna, Rentsch, Christopher T, Williamson, Elizabeth, Hulme, William, Tomlinson, Laurie, Mathur, Rohini, Drysdale, Henry, Eggo, Rosalind M, Wong, Angel Yun, Forbes, Harriet, Parry, John, Hester, Frank, Harper, Sam, Douglas, Ian, Smeeth, Liam, Goldacre, Ben
Publicado 2021

OpenSAFELY NHS Service Restoration Observatory 2: changes in primary care clinical activity in England during the COVID-19 pandemic

por Curtis, Helen J, MacKenna, Brian, Wiedemann, Milan, Fisher, Louis, Croker, Richard, Morton, Caroline E, Inglesby, Peter, Walker, Alex J, Morley, Jessica, Mehrkar, Amir, Bacon, Sebastian CJ, Hickman, George, Evans, David, Ward, Tom, Davy, Simon, Hulme, William J, Macdonald, Orla, Conibere, Robin, Lewis, Tom, Myers, Martin, Wanninayake, Shamila, Collison, Kiren, Drury, Charles, Samuel, Miriam, Sood, Harpreet, Cipriani, Andrea, Fazel, Seena, Sharma, Manuj, Baqir, Wasim, Bates, Chris, Parry, John, Goldacre, Ben
Publicado 2023

OpenSAFELY: factors associated with COVID-19 death in 17 million patients

por Williamson, Elizabeth J, Walker, Alex J, Bhaskaran, Krishnan, Bacon, Seb, Bates, Chris, Morton, Caroline E, Curtis, Helen J, Mehrkar, Amir, Evans, David, Inglesby, Peter, Cockburn, Jonathan, McDonald, Helen I, MacKenna, Brian, Tomlinson, Laurie, Douglas, Ian J, Rentsch, Christopher T, Mathur, Rohini, Wong, Angel YS, Grieve, Richard, Harrison, David, Forbes, Harriet, Schultze, Anna, Croker, Richard, Parry, John, Hester, Frank, Harper, Sam, Perera, Rafael, Evans, Stephen JW, Smeeth, Liam, Goldacre, Ben
Publicado 2020

Association between oral anticoagulants and COVID-19-related outcomes: a population-based cohort study

por Wong, Angel YS, Tomlinson, Laurie, Brown, Jeremy P, Elson, William, Walker, Alex J, Schultze, Anna, Morton, Caroline E, Evans, David, Inglesby, Peter, MacKenna, Brian, Bhaskaran, Krishnan, Rentsch, Christopher T, Powell, Emma, Williamson, Elizabeth, Croker, Richard, Bacon, Seb, Hulme, William, Bates, Chris, Curtis, Helen J, Mehrkar, Amir, Cockburn, Jonathan, McDonald, Helen I, Mathur, Rohini, Wing, Kevin, Forbes, Harriet, Eggo, Rosalind M, Evans, Stephen JW, Smeeth, Liam, Goldacre, Ben, Douglas, Ian J
Publicado 2022

Waning effectiveness of BNT162b2 and ChAdOx1 covid-19 vaccines over six months since second dose: OpenSAFELY cohort study using linked electronic health records

por Horne, Elsie M F, Hulme, William J, Keogh, Ruth H, Palmer, Tom M, Williamson, Elizabeth J, Parker, Edward P K, Green, Amelia, Walker, Venexia, Walker, Alex J, Curtis, Helen, Fisher, Louis, MacKenna, Brian, Croker, Richard, Hopcroft, Lisa, Park, Robin Y, Massey, Jon, Morley, Jessica, Mehrkar, Amir, Bacon, Sebastian, Evans, David, Inglesby, Peter, Morton, Caroline E, Hickman, George, Davy, Simon, Ward, Tom, Dillingham, Iain, Goldacre, Ben, Hernán, Miguel A, Sterne, Jonathan A C
Publicado 2022

Risk of COVID-19-related death among patients with chronic obstructive pulmonary disease or asthma prescribed inhaled corticosteroids: an observational cohort study using the OpenS...

por Schultze, Anna, Walker, Alex J, MacKenna, Brian, Morton, Caroline E, Bhaskaran, Krishnan, Brown, Jeremy P, Rentsch, Christopher T, Williamson, Elizabeth, Drysdale, Henry, Croker, Richard, Bacon, Seb, Hulme, William, Bates, Chris, Curtis, Helen J, Mehrkar, Amir, Evans, David, Inglesby, Peter, Cockburn, Jonathan, McDonald, Helen I, Tomlinson, Laurie, Mathur, Rohini, Wing, Kevin, Wong, Angel Y S, Forbes, Harriet, Parry, John, Hester, Frank, Harper, Sam, Evans, Stephen J W, Quint, Jennifer, Smeeth, Liam, Douglas, Ian J, Goldacre, Ben
Publicado 2020

Use of non-steroidal anti-inflammatory drugs and risk of death from COVID-19: an OpenSAFELY cohort analysis based on two cohorts

por Wong, Angel YS, MacKenna, Brian, Morton, Caroline E, Schultze, Anna, Walker, Alex J, Bhaskaran, Krishnan, Brown, Jeremy P, Rentsch, Christopher T, Williamson, Elizabeth, Drysdale, Henry, Croker, Richard, Bacon, Seb, Hulme, William, Bates, Chris, Curtis, Helen J, Mehrkar, Amir, Evans, David, Inglesby, Peter, Cockburn, Jonathan, McDonald, Helen I, Tomlinson, Laurie, Mathur, Rohini, Wing, Kevin, Forbes, Harriet, Eggo, Rosalind M, Parry, John, Hester, Frank, Harper, Sam, Evans, Stephen JW, Smeeth, Liam, Douglas, Ian J, Goldacre, Ben
Publicado 2021

Association between warfarin and COVID-19-related outcomes compared with direct oral anticoagulants: population-based cohort study

por Wong, Angel Y. S., Tomlinson, Laurie A., Brown, Jeremy P., Elson, William, Walker, Alex J., Schultze, Anna, Morton, Caroline E., Evans, David, Inglesby, Peter, MacKenna, Brian, Bhaskaran, Krishnan, Rentsch, Christopher T., Powell, Emma, Williamson, Elizabeth, Croker, Richard, Bacon, Seb, Hulme, William, Bates, Chris, Curtis, Helen J., Mehrkar, Amir, Cockburn, Jonathan, McDonald, Helen I., Mathur, Rohini, Wing, Kevin, Forbes, Harriet, Eggo, Rosalind M., Evans, Stephen J. W., Smeeth, Liam, Goldacre, Ben, Douglas, Ian J.
Publicado 2021

Overall and cause-specific hospitalisation and death after COVID-19 hospitalisation in England: A cohort study using linked primary care, secondary care, and death registration dat...

por Bhaskaran, Krishnan, Rentsch, Christopher T., Hickman, George, Hulme, William J., Schultze, Anna, Curtis, Helen J., Wing, Kevin, Warren-Gash, Charlotte, Tomlinson, Laurie, Bates, Chris J., Mathur, Rohini, MacKenna, Brian, Mahalingasivam, Viyaasan, Wong, Angel, Walker, Alex J., Morton, Caroline E., Grint, Daniel, Mehrkar, Amir, Eggo, Rosalind M., Inglesby, Peter, Douglas, Ian J., McDonald, Helen I., Cockburn, Jonathan, Williamson, Elizabeth J., Evans, David, Parry, John, Hester, Frank, Harper, Sam, Evans, Stephen JW, Bacon, Sebastian, Smeeth, Liam, Goldacre, Ben
Publicado 2022

Effect of pre-exposure use of hydroxychloroquine on COVID-19 mortality: a population-based cohort study in patients with rheumatoid arthritis or systemic lupus erythematosus using...

por Rentsch, Christopher T, DeVito, Nicholas J, MacKenna, Brian, Morton, Caroline E, Bhaskaran, Krishnan, Brown, Jeremy P, Schultze, Anna, Hulme, William J, Croker, Richard, Walker, Alex J, Williamson, Elizabeth J, Bates, Chris, Bacon, Seb, Mehrkar, Amir, Curtis, Helen J, Evans, David, Wing, Kevin, Inglesby, Peter, Mathur, Rohini, Drysdale, Henry, Wong, Angel Y S, McDonald, Helen I, Cockburn, Jonathan, Forbes, Harriet, Parry, John, Hester, Frank, Harper, Sam, Smeeth, Liam, Douglas, Ian J, Dixon, William G, Evans, Stephen J W, Tomlinson, Laurie, Goldacre, Ben
Publicado 2020

Hydroxychloroquine treatment does not reduce COVID-19 mortality; underdosing to the wrong patients? – Authors' reply

por Rentsch, Christopher T, DeVito, Nicholas J, MacKenna, Brian, Morton, Caroline E, Bhaskaran, Krishnan, Brown, Jeremy P, Schultze, Anna, Hulme, William J, Croker, Richard, Walker, Alex J, Williamson, Elizabeth J, Bates, Chris, Bacon, Seb, Mehrkar, Amir, Curtis, Helen J, Evans, David, Wing, Kevin, Inglesby, Peter, Mathur, Rohini, Drysdale, Henry, Wong, Angel Y S, McDonald, Helen I, Cockburn, Jonathan, Forbes, Harriet, Parry, John, Hester, Frank, Harper, Sam, Smeeth, Liam, Douglas, Ian J, Dixon, William G, Evans, Stephen J W, Tomlinson, Laurie, Goldacre, Ben
Publicado 2021

OpenSAFELY NHS Service Restoration Observatory 1: primary care clinical activity in England during the first wave of COVID-19

por Curtis, Helen J, MacKenna, Brian, Croker, Richard, Inglesby, Peter, Walker, Alex J, Morley, Jessica, Mehrkar, Amir, Morton, Caroline E, Bacon, Seb, Hickman, George, Bates, Chris, Evans, David, Ward, Tom, Cockburn, Jonathan, Davy, Simon, Bhaskaran, Krishnan, Schultze, Anna, Rentsch, Christopher T, Williamson, Elizabeth J, Hulme, William J, McDonald, Helen I, Tomlinson, Laurie, Mathur, Rohini, Drysdale, Henry, Eggo, Rosalind M, Wing, Kevin, Wong, Angel YS, Forbes, Harriet, Parry, John, Hester, Frank, Harper, Sam, Evans, Stephen JW, Douglas, Ian J, Smeeth, Liam, Goldacre, Ben
Publicado 2021

Changes in medication safety indicators in England throughout the covid-19 pandemic using OpenSAFELY: population based, retrospective cohort study of 57 million patients using fede...

por Fisher, Louis, Hopcroft, Lisa EM, Rodgers, Sarah, Barrett, James, Oliver, Kerry, Avery, Anthony J, Evans, Dai, Curtis, Helen, Croker, Richard, Macdonald, Orla, Morley, Jessica, Mehrkar, Amir, Bacon, Sebastian, Davy, Simon, Dillingham, Iain, Evans, David, Hickman, George, Inglesby, Peter, Morton, Caroline E, Smith, Becky, Ward, Tom, Hulme, William, Green, Amelia, Massey, Jon, Walker, Alex J, Bates, Christopher, Cockburn, Jonathan, Parry, John, Hester, Frank, Harper, Sam, O’Hanlon, Shaun, Eavis, Alex, Jarvis, Richard, Avramov, Dima, Griffiths, Paul, Fowles, Aaron, Parkes, Nasreen, Goldacre, Ben, MacKenna, Brian
Publicado 2023